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State of ACRIN : 10 years of investment. Mitchell Schnall MD, PhD Professor of Radiology University of Pennsylvania ACRIN Network Chair. Primary Scientific Objectives. Strategies for Imaging Surveillance of Populations at High Risk for Cancer

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Mitchell Schnall MD, PhD Professor of Radiology University of Pennsylvania ACRIN Network Chair

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Mitchell schnall md phd professor of radiology university of pennsylvania acrin network chair

State of ACRIN :

10 years of investment

Mitchell Schnall MD, PhD

Professor of Radiology

University of Pennsylvania

ACRIN Network Chair


Mitchell schnall md phd professor of radiology university of pennsylvania acrin network chair

Primary Scientific Objectives

  • Strategies for Imaging Surveillance of Populations at High Risk for Cancer

  • Imaging Approaches to the Characterization of Disease in Order to Guide Targeted Therapy

  • Biomarkers of Therapeutic Response for Implementation in Clinical Trials and Clinical Care


Acrin organization 1999

ACRIN ORGANIZATION: 1999

Data and Safety

Monitoring Committee

Network Chair

Network Deputy Chair

Advisory Panel

Network

Administration

Biostatistical & Data

Management Center

Vice Chair

Disease Sites

Vice Chair

Modalities

Vice Chair

Methods

Vice Chair

Basic Sciences

Vice Chair

for Institutional

Participants

Vice Chair

Industry/Insurers

Vice Chair

Publications

Scientific Committees

Design &

Analysis

Oncologic

Pathology

Institutional

Participants

GI

Functional/Meta-

bolic Imaging

Outcomes and

Quality of Life

Quality Contol

Urinary

Receptor

Delivery Sys

GYN

Economics and

Cost Impact

Medical

Specialties

Advisory Comm.

Heart &

Vasculature

Nuc Med

PET/Spect

MRI/MRS

Special

Populations

CNS

Conventional/

CT

Breast

Physics &

Engineering

Head & Neck

Interventional

Min Invasive

Musculoskeletal

Ultrasound

Lung

Image & Info

Tech

Pediatrics

Psychophysics


Mitchell schnall md phd professor of radiology university of pennsylvania acrin network chair

ACRIN Organizational Chart

Steering Committee

Network Chair

Mitchell Schnall, MD, PhD

University of Pennsylvania

Deputy Chairs

Anat/Fxn Imaging

Denise Aberle, MD

UCLA

Molecular Imaging

Barry Siegel, MD

Washington University

Biostatistical & Data Management Center

Brown University

Chair

Constantine Gatsonis, PhD

Deputy Chair

Jeffrey Blume, PhD.

NCI

Jim Tatum, MD

Cancer ImagingProgram

Leadership Council

Mitchell Schnall, MD, PhD

University of Pennsylvania

Advisory Panel

Hal Kundel, MD

University of Pennsylvania

Data & SafetyMonitoring Committee

Daniel Sargent, PhD

Mayo Clinic

Network Administration

Charles Apgar

ACR Philadelphia

Outcomes & Economics Core Laboratory

William Black,MD

Dartmouth Medical School

Scientific Support

Committees

Support

Committees

Disease Site

Committees

Breast

Etta Pisano, MD

University North Carolina

Informatics

Daniel Rubin

Stanford University

Patient Advocacy

Barbara LeStage, MHP

Media / Publications and Dissemination

Committee

Vice Chair

Laurie Fajardo, MD

University of Iowa

Institutional Participants Committee

Vice Chair

Chris Comstock, MD

UCSD

Quality Control

Mitchell Schnall, MD, PhD

University of Pennsylvania

Abdominal

Fergus Coakley, MD

Univ Calif San Francisco

Core Laboratory

PET/Nuc Medicine

Barry Siegel, MD

Washington University

MR/CT

Mark Rosen, MD, PhD

University of Pennsylvania

Research Associates

Wendy Smith, RT

Rhode Island Hospital

Gynecological

Special Populations

Elizabeth Patterson, MD

Head/Neck/CNS

Greg Sorensen, MD

MassachusettsGeneralHosp

Ultrasound Working Group

Barry Goldberg, MD

Thomas Jefferson University

Thoracic

Caroline Chiles, MD

Wake Forest University

Experimental Imaging

David Mankoff, MD

University of Washington


Scientific progress

Scientific Progress

Disease Site

Opened

Completed Accrual

In Development

Closed Unsuccessfully

Breast

1

4

1

0

Abdominal

2

4

1

2

GYN

1

1

1

0

CNS/Head and Neck

1

2

2

0

Thoracic

2

1

1

1

EISC

0

0

 2

 0

ACRIN Trial Status by Disease Site


Acrin success

ACRIN Success

  • 117 sites have participated ACRIN trials

  • Over 76,500patients have been accrued to ACRIN trials

  • Over 20 million images have been collected into the ACRIN database

  • Over 70 abstract presented

    • 10 ACRIN research presentation scheduled at RSNA 2008

  • Over 50 Scientific publications

    • 3 NEJM/1JAMA


Mitchell schnall md phd professor of radiology university of pennsylvania acrin network chair

The National CTC Trial Results Make it to Times Square


Extending acrin s impact

Extending ACRIN’s Impact

  • Awarded RO1 for establishing VIEW

    • Imaging core lab services to the cooperative groups

    • Partner with QARC and CALGB

  • Established ACRIN PA

    • Supported by PA tobacco fund

    • Cartilage Assessment

    • Radial DCE MRI

    • Amyloid imaging

    • Coronary CTA

  • *Developed the ACRIN Cardiovascular Committee

  • ACRIN “projects”

*initiative supported by the ACRIN Fund for Imaging Innovation


Challenges

Challenges

  • Strong scientific pipeline

    • Balance in the research portfolio

    • Focus on imaging science

    • Engagement of clinical community

  • Maintaining accrual

  • Build publication record


Case accrual

Case Accrual


Cost per case has been increasing

Cost per case has been increasing

Assuming 6 committees:

73 cases/committee/year


Mitchell schnall md phd professor of radiology university of pennsylvania acrin network chair

Special

Populations

Individual

Investigators

Patient

Advocacy

Committee

Members

Outcome

Economics

Biostatistics

Imaging

Core Lab

Cooperative

Groups

Primary Scientific Objectives

INPUT from

ACRIN Resources

Trial Ideas

  • ACRIN SCIENTIFIC COMMITTEES

    • Review Idea

    • Impact

    • Feasibility

    • Strategy

    • Develop Concept

    • Assemble Experts

    • Symposium at Fall Meeting

    • Define Imaging Approach

    • Identify Collaborators

  • Steering Committee Response

  • Approve for Development and

    CTEP Concept Submission

  • Disapprove

  • Request Revision

  • Presentation to Steering Committee

  • Written Concept

  • Trial PI / Committee Chair Present

  • ACRIN STEERING COMMITTEE

    • Review with Respect to:

    • Scientific Impact

    • Generalizability of Technology

    • Feasibility

    • Cost


Publications patient accrual protocol pipeline

Committee Meeting

PublicationsPatient AccrualProtocol Pipeline


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