Echemi Chemical 3-Chloro-4-hydroxybenzaldehyde Description

1. CAS No:2420-16-8 Formula:C7H5ClO2 Synonyms:AKOSB028967;TIMTEC-BBSBB005887;TIMTEC-BBSBB004014;3-CHLORO-4-HYROXYBEN ZALDEHYDE;3-CHLORO-4-HYDROXYBENZALDEHYDE;Benzaldehyde,3-chloro-4-hydroxy-;3-Chloro-4 -hydroxybenzaldehyde98%;3-Chloro-4-hydroxybenzaldehyde,99+% China Export:From 2018.11 to 2019.11, total export volume of 3-Chloro-4-hydroxybenzaldehyde from China was 5,124,452KG while total export value was $52,865,496. The biggest proportion of exporting volume in the last 12 months was 13.79% in 2019.01. Echemi Chemical 3-Chloro-4-hydroxybenzaldehyde Description White solid Echemi Chemical 3-Chloro-4-hydroxybenzaldehyde Basic Attributes CAS No：2420-16-8 Molecular Formula ：C7H5ClO2 Molecular Mass ：156.565 Exact Mass ：155.997803 PSA ：37.3 A^2 LogP ：1.9 InChIKeys ：VGSOCYWCRMXQAB-UHFFFAOYSA-N H-bond Acceptor ：2 H-bond Donor ：1 SP3 ：0.00 RBN ：1 Echemi Chemical 3-Chloro-4-hydroxybenzaldehyde Characteristics Density ：1.4±0.1 g/cm3 Melting Point ：145-147 °C(lit.) Bolling Point ：251.1°C at 760 mmHg Flash Point ：105.6±21.8 °C

2. Refractive Index ：1.632 Echemi Chemical 3-Chloro-4-hydroxybenzaldehyde Safety Information HS Code ：2913000090 UN No. ：NONH for all modes of transport WGK_Germany ：3 Risk Code ：36/37/38-43-41-20/21/22 Safety Instructions ：S26-S37/39-S36/37/39 Dangerous Mark ：Xn: Harmful; P Code ：P261-P280-P305 + P351 + P338 Hazard Statements ：H302-H315-H317-H318-H335 Echemi Chemical 3-Chloro-4-hydroxybenzaldehyde Production Methods N-chlorosuccinimide (1.1 g, 8.18 mmol) was added to a solution of 4- hydroxybenzaldehyde (1.0 g, 8.18 mmol) in 10 ml of chloroform and the mixture was heated at 50 N-chlorosuccinimide (1.1 g, 8.18 mmol) was added to a solution of 4- hydroxybenzaldehyde (1.0 g, 8.18 mmol) in 10 ml of chloroform and the mixture was heated at 50 To a stirred solution of 4-hydroxybenzaldehyde (5.0 g, 40.0 mmol) in DCM (50 mL) SOClPreparation 75 To a well stirred solution of p-hydroxybenzaldehyde (1.0 mmol) in CHClCompound R53 (4.9 g, 40 mmol) was dissolved in 80 ml of dry chloroform, protected by argon, After heating to reflux, a solution of 20 ml of sulfuryl chloride (3.2 ml, 40 mmol) in chloroform was slowly added dropwise and then refluxed overnight.

3. The reaction solution was spin-dried and pure petroleum ether was passed through a silica gel column to obtain 2.5 g (40percent).General procedure: To a solution of substrates (1a–1q, 0.15 mmol) in trifluoroacetic acid (5 ml), hexamethylenetetramine (0.3 mmol) and cuprous oxide (0.15 mmol) were added. The reaction mixture was refluxed for about 5 h, cooled to room temperature, followed by addition of hydrochloric acid (3 N, 5 ml). After stirring for another 1 h, the solution was concentrated under reduced pressure. The products were purified by silica gel column chromatography (200–300 mesh).