Research strategy for rnoh ioms
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Trust Board April 2008. Research strategy for RNOH-IOMS. David Marsh Professor of Clinical Orthopaedics Institute of Orthopaedics and Musculoskeletal Science, University College London Royal National Orthopaedic Hospital Stanmore, UK.

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Research strategy for rnoh ioms

Trust Board

April 2008

Research strategy for RNOH-IOMS

David Marsh

Professor of Clinical Orthopaedics

Institute of Orthopaedics and Musculoskeletal Science, University College London

Royal National Orthopaedic HospitalStanmore, UK


A joint ioms rnoh academic strategy is an essential part of the outline business case

A joint IOMS-RNOH academic strategy is an essential part of the Outline Business Case

  • One of three stipulations in the letter from the SHA inviting submission:“set out a clear commitment to support the work of the university and its partners in achieving AHSC status and strengthening the Orthopaedic Institute”


Academic health science centre

Academic Health Science Centre

CLINICAL

EXCELLENCE,INTEGRATION

RESEARCH

EDUCATION

How are we going to fund this?

  • Joint Academic Plan:

    • integration of UG and PG education

    • R&D management into IOMS

    • Research strategy


Research strategy

Research Strategy

Health services research

  • Focused on musculoskeletal system but full spectrum

Basic science

Clinical trials

Translational Experimental

  • Five themes, building on track record and patient needs

    • Innovative implant design

    • Cell therapy and tissue engineering

    • Disability and improvement of quality of life

    • Building the musculoskeletal evidence base

    • Sarcoma medicine


Tapping in to ucl

Tapping in to UCL

Health services research

Musculoskeletal Consortium

Basic science

Clinical trials

Translational Experimental

  • Five centres in IOMS

    • Bioengineering

    • Tissue engineering

    • Clinical academic

    • Rehabilitation

    • Pathology

  • Innovative implant design

  • Cell therapy and tissue engineering

  • Disability and improvement of quality of life

  • Building the musculoskeletal evidence base

  • Sarcoma medicine

Engineering

Centre for Ageing

Cancer Institute


Funding

Funding

UKCC

EPSRCBBSRC

MRC

NIHR

Basic science

Translational Experimental

Clinical trials

Health services research

ARC, charities


National institute for health research the new research environment

National Institute for Health Research - the new research environment

  • Concentration of funded clinical research in fewer, larger centres

    • Large research teams

    • Epidemiology, health economics vital

    • Many Trusts giving up and outsourcing research management

  • Competition with all other specialities - fierce

    • Priorities in cancer, neuro, endocrine, mental, children

    • Role of rheumatology

  • Research governance demands tighter

Transform or fade out


Nihr funding streams

NIHR funding streams

  • Comprehensive biomedical research centresSpecialist BMRCsBiomedical Research Units

    • Musculoskeletal in Oxford, Sheffield, Leeds

  • Local Comprehensive Research Networks

  • HTA, RfPB, NEAT, RISC

  • Applied Research Programme Grants

  • Technology Support Board


Mrc translational research call

MRC Translational Research Call

  • £241m extra, most on translational research

    • Bottlenecks

  • Pan-UCL bid going in

    • MRC Centre for Cell and Gene Therapy

  • Stanmore hopefully to contribute cell therapy in the musculoskeletal system


Cell based therapy

Cell-based therapy

  • Clinical trials in ACI

  • Preclinical work on bone, collagen

  • Regenerative Medical Systems - UK

  • Translational teams

    • Bone

    • Tendon

    • Cartilage


Stanmore clinical research facility

Stanmore Clinical Research Facility

  • At present a joint venture between RNOHT and UCLB – may change

  • Goal is to facilitate rapid study design, costing, governance and conduct

  • Both investigator-led and commercial

    • All must be fully funded

  • Building a clinical research network is crucial

    • eg fragility fractures and drugs that enhance fracture healing


Research pipeline in cell based therapy

Research pipeline in cell-based therapy

Health services research

Basic science

Clinical trials

Translational Experimental

What phenotype of cultured cells produces the best clinical response?

Is it cost-effective to culture-expand cells rather than use bone marrow?

Can we design new way ways of efficiently expanding stem cells?

IOMS

RMS-UK

SCRF


Integrated academic training programme

Integrated Academic Training Programme

  • Four Academic Clinical Fellows

  • Two Clinical Lecturers


Research strategy for rnoh ioms

UCL Dean and Research Vice-Provost

Trust Board

UCL and Partners Health Sciences Research Deanery

Academic Research Board

Research Governance Committee

Education Committee

Research Committee

PPI group


Research support staff

Research Support Staff

  • Academic Clinical Centre of IOMS

  • MRC Clinical Trial Unit support

  • Chair of Musculoskeletal Epidemiology

    • Alex MacGregor – starting Sep 08

  • R&D Director and Manager (Joseph Datukasi)

  • Nerina – Head of Academic Business Development

  • SCRF staff

  • IT systems for research support – Simon Grange


Research governance

Research Governance

  • MHRA inspection

  • Duties of Principal Investigators

  • Duties of RNOH as a sponsor

  • Our IT solutions


Mhra inspection

MHRA Inspection


Mhra inspection1

MHRA Inspection


Support we can offer

Support we can offer

  • Training

    • Executive GCP training

    • Research Pack

    • Best methodological practice in musculoskeletal research

  • Governance

    • Integration locally with Risk assessment

    • Integration with Local Comprehensive Research Network

  • Research

    • Finding Research Partnerships

    • Developing hypotheses and designing studies

    • Finding funding sources


Research governance1

Research Governance


Clinical trials support

Clinical Trials Support

  • Being tested by our iBSc & MSc students


Electronic patient record

Electronic Patient Record


Research strategy for rnoh ioms

Clinical Sen Lec

MSK epidemiologist

R&D Director

R&D Manager

Biostatistician

Health economist

05

06

07

08

09

10

11

12

My tenure

Team building

IT/governance support

Medical physics

Joint academic strategy capacity building

SCRF

Regenerative Medical Systems - UK

Multidisciplinary MSc

Integrated Academic Training Programme


Research strategy for rnoh ioms

05

06

07

08

09

10

11

12

Expenditure

NHS R&D

UCL

Grant targetoverheads, contributions to salary, SCRF profit

MRC stem cells in nonunion 300k

Pfizer fracture accelerating drug 500k

TSB grant 500k

NIHR Applied Research Programme £2m


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