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Mood Disorders

Mood Disorders. An Overview of Mood Disorders. Gross Deviations in Mood Depression: “The Low” The “Common Cold” of Mental Illness Major Depressive Episode is Most Common Mania: “The High” Abnormally Exaggerated Elation, Joy, or Euphoria. An Overview of

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Mood Disorders

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  1. Mood Disorders

  2. An Overview of Mood Disorders • Gross Deviations in Mood • Depression: “The Low” • The “Common Cold” of Mental Illness • Major Depressive Episode is Most Common • Mania: “The High” • Abnormally Exaggerated Elation, Joy, or Euphoria

  3. An Overview of Mood Disorders Mania Depression

  4. The Structure of Mood Disorders • Unipolar Mood Disorder • Either Depression or Mania • Bipolar Mood Disorder • Alternates Between Depression and Mania • Important to Determine the Course • Temporal Patterning of the Episodes

  5. The Nature of Mood Disorders • Depressive Disorders • Major Depression • PDD, formerly Dysthymic Disorder • “Double Depression” - - dysthymia punctuated by period of major depression • Bipolar I and Bipolar II Disorders • Cyclothymic Disorder

  6. Depressive Disorders Major Depressive Episode • Clinical Description • Extremely Depressed Mood • Lasting at Least 2 Weeks • Cognitive Symptoms • Anhedonia • Vegetative Symptoms • Single or Recurrent Episode • No Manic or Hypomanic Episodes

  7. Depressive Disorders PDD-Dysthymia • Clinical Description • Similar to Major Depression BUT With a Different Course • Symptoms are Milder • Symptoms can Last 20-30+ Years • Persistently Depressed Mood for 2+ Years • Cannot be Symptom Free > 2 Months

  8. Depressive Disorders Persistent Depressive Disorder (Dysthymia) • Facts and Statistics • Mean Age of Onset Early 20s • Onset Prior to Age 20 • Greater Chronicity • Poor Prognosis • Major Depressive Episodes are Common

  9. Depressive Disorders Double Depression • Clinical Description • Suffer From Both • Major Depression Episodes • PDD - Dysthymic Disorder • Dysthymia Usually Begins First • Associated With Severe Pathology • A Problematic Future Course

  10. Depressive Disorders Double Depression • Clinical Description Dysthymia Dysthymia Major Depression

  11. Bipolar Disorders • Major Features • Experience Both • Manic Episodes • Major Depressive Episodes • Roller Coaster of Mood • What are Manic Episodes?

  12. Bipolar Disorders • Mania and Hypomania • Elevated Mood • Grandiosity • Increased Activity • Varied Impairment

  13. Bipolar Disorders: Bipolar I • Clinical Description Mania Major Depression

  14. Bipolar Disorders: Bipolar II • Clinical Description • Major Depressive Episodes Alternate With • Hypomanic Episodes

  15. Bipolar Disorders: Cyclothymia • Clinical Description • Milder Depressive Episodes Alternate With • Hypomanic Episodes

  16. Bipolar Disorders: Cyclothymia • Clinical Description Hypomania Dysthmia

  17. Bipolar Disorders • General Facts and Statistics • Bipolar I • Onset Around 18 Years • Bipolar II • Onset Around 22 Years • 16% Commit Suicide • Cyclothymia • Typically Chronic

  18. Feature Specifiers in Mood Disorders • Descriptions of Recent Episode and PatternVaries • 1. Atypical • Pertains to Depressive Episodes and Dysthymia, not Manic Episodes • Typically Overeat and Oversleep

  19. Feature Specifiers in Mood Disorders • Recent Episode and Pattern • Atypical (overeat, oversleep, wght gain – keep interested, can experience pleasure) • 2. Melancholic • Pertains to Major Depressive Episode Only • More Severe Symptoms • Strong Biological Component

  20. Feature Specifiers in Mood Disorders • Recent Episode and Pattern • Atypical • Melancholic • 3. Mixed Features • With some mania symptoms

  21. Feature Specifiers in Mood Disorders • Recent Episode and Pattern • Atypical • Melancholic • 4. Catatonic • Can be part of Major Depression and Mania • Very Serious Condition • Catalepsy (“Muscle Rigidity”) • Mixed

  22. Feature Specifiers in Mood Disorders • Recent Episode and Pattern • Atypical • Melancholic • Catatonic • Mixed • 5. Psychotic • Hallucinations and Delusions • Very Rare but Serious Condition • Poor Treatment Response

  23. Feature Specifiers in Mood Disorders • Recent Episode and Pattern • Atypical • Melancholic • Catatonic • Mixed • 6. Peripartum • Major Depression and Mania • Prior to…Four Weeks Following Birth…and up to a year: high % • Mood Episodes of a Psychotic Nature Relatively Rare • Psychotic

  24. Feature Specifiers in Mood Disorders • Recent Episode and Pattern • Atypical • Melancholic • Catatonic • Mixed • Psychotic • Peripartum • Anxious Distress

  25. Specifiers Describing Course • Course and Pattern • Rapid-Cycling • Seasonal Pattern • Bipolar and Recurrent Major Depression • Episodes During Certain Seasons

  26. Other Depressive Disorders - new to DSM-5 • Premenstrual Dysphoric Disorder (PMDD) • 2- 5% of women meet criteria • Disruptive Mood Dysregulation Disorder • Children: increased diagnosis for bipolar, up 40% between 1995 and 2005 • Bipolar (NOS)

  27. Mood Disorders: Facts and Prevalence • About 16% Lifetime Global Prevalence MDD • Past Year: Bipolar-.8% Maj Depression-6% • Females > Males • Major Depression and Dysthymia • Females = Males • Bipolar Disorders

  28. Mood Disorders: Biological Causes • Biological Dimensions • Family Studies • Twin Studies • As Severity Increases, so Does the Genetic Connection • No Single Genetic Link

  29. Mood Disorders: Biological Causes • Neurotransmitters • The Serotonin Connection • Endocrine Function • Elevated Cortisol • Dexamethasone Suppression Test: cortisol suppressed in non-depressed people, not in severely depressed….but….

  30. Mood Disorders: Biological Causes • Sleep and Circadian Rhythms • Sleep Disturbances are Common • More intense and earlier start to REM Sleep among the Depressed • Diminished Deep Sleep • Disruption of Circadian Rhythms

  31. Mood Disorders: Psychological Causes • Stressful Life Events; Loss • Learned Helplessness • Attributional Style • Internal • Stable • Global

  32. Mood Disorders: Psychological Causes • NegativeCognitive Biases • Beck’s Cognitive Triad • Negative Schema About Self, World, & Future

  33. Deadlier Side of Mood Disorders: Suicide • In the United States: • About 30,000 Kill Themselves Annually • More Die from Suicide Each Year Than Homicide (about 20,000) • More Common Among Whites, Native Americans • Increasing in Adolescents (3rd leading cause of death) & Elderly (globally, the elderly have highest suicide rate, esp. males) • Males > Females in Killing Themselves • Females > Males in Attempts

  34. Deadlier Side of Mood Disorders: Suicide • Approximately 500,000 people each year require ER treatment as a result of attempted suicide • Suicidal behavior typically occurs in the presence of mental illness or substance use disorders • Firearms account for 59% of all suicide deaths • Website of Extreme and Urgent Interest • suicidology.org

  35. Treatment of Mood Disorders • Medications • Tricyclic Antidepressants Imipramine (Tofranil) Amitriptyline (Elavil) • Block Neurotransmitter Reuptake • Side Effects

  36. Treatment of Mood Disorders • Medications • MAO Inhibitors • Block Enzyme MonoAmine Oxidase • The Result? More Neurotransmitter is Available • Side Effects and Complications

  37. Treatment of Mood Disorders • Medications • SSRIs • Block Reuptake of Serotonin- Prozac • SSNRIs

  38. Treatment of Mood Disorders • Medications - Bipolar • Lithium, Depakote, Lamictal…Effective for Manic Episodes • Lithium Must be Carefully Regulated • Other Medical Treatments • Electroconvulsive Therapy (ECT) • TMS

  39. Treatment of Mood Disorders • Psychological Interventions • Combined Treatments?

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