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Fertility at midlife

Fertility at midlife. Prof. Duru Shah. Career oriented women.  rate of divorces. Late marriages. Delayed childbearing. Re-marriage. The need for fertility at midlife. Childhood cancer survivors  young women with low ovarian reserve. Infertility increases with age. 29%. 22%. 15%.

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Fertility at midlife

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  1. Fertility at midlife Prof. Duru Shah

  2. Career oriented women  rate of divorces Late marriages Delayed childbearing Re-marriage The need for fertility at midlife Childhood cancer survivors  young women with low ovarian reserve

  3. Infertility increases with age 29% 22% 15% % infertility 9% 7% Courtesy American Society for Reproductive Medicine 2007

  4. Causes of poor Results in older women • Follicular atresia • ↑ Spontaneous abortion rates due ↑ aneuploidy • ↓ Endometrial Receptivity • ↓ Oocyte Quality

  5. 7.0 5.0 3.0 1.0 0.3 Birth 3 6 9 5 10 30 50 Age (months) Age ( yrs ) The Rise And Fall Of Ovarian Reserve Prevalence of diminished OR is 10% in the general infertility practice Ref : N. S. Macklon Seminars in Reproductive Medicine 2005

  6. Quantitative & Qualitative decline of follicle pool Ref : Broekmans FJ et al Hum Reprod Update 12(6) 685-718, 2006

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