Case Study on Human Papillomavirus. Teresa Dominguez LaTasha Hardy Francisca Mata. Case Study Overview. 25-five-year-old carpenter. Several hyperkeratotic papules (warts) on Palm inside of index finger. Do not change size. Cause only minimal discomfort.
Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.
Case Study on
Case Study Overview
What are Warts?
Non-cancerous skin growths in the epidermis
Caused mostly by HPV-1, 2 and 4
Usually skin-colored and feel rough to the
Foot (planar) warts
Fig. 1 HPV infecting the
Fig. 2 More extreme case of
Will this virus infection spread to
other body parts?
Transmission via contact
Infection of basal cells of epidermis
Breach in the skin predisposing factor
There is a possibility of spreading warts to other parts of your body through breaks in the skin.
After its disappearance, is the infection
likely to be completely resolved
or persist in the host?
Once infected with a specific HPV type,
it is unlikely
Can present with numerous treatment
Recurrent infections with same HPV type
computer colorized EM image of Papillomavirus capsid
Genomic organization of HPV-16
What is known
This type of HPV is not associated with human cancer
HPV-2 (hand warts)
Common skin wart
Does not cause genital warts
Not associated with development of cancer
15 classified as “high-risk”
HPV and Cancer
Antonsson, A, et.al. The Ubiquity and Impressive Genomic Diversity of Human Skin Papillomaviruses Suggest a Commensalic Nature of These Viruses. J. Virol. 2000. Vol. (74)
Centers for Disease Control and Prevention. 2007 Human Papillomavirus: HPV Information for Clinicians (Brochure). Washington, DC. April 2007
Desante, C., and Demeret, C. Control of papillomavirus DNA replication and transcription. Seminars in Cancer Biology, 1996: (51): 339–347
Kari, I. et. al. Antisense RNA directed to the human papillomavirus type 16 E7 mRNA from herpes simplex virus type 1 derived vectors is expressed in CaSki cells and downregulates E7 mRNA. J. Virol. 2007, 4:47
Kingsley K, Johnson D, O’Malley, S. Transfection of oral squamous cell carcinoma with human papillomavirus-16 induces proliferative and morphological changes in vitro. Cancer Cell Int. 2006 May 22;6:14
Lambert, P. Papillomavirus Replication. J. Virol. 1991, (65):3417-3420.
Lehtinen, M. Serologically diagnosed infection with human papillomavirus type 16 and risk for subsequent development of cervical carcinoma: nested case-control study. BMJ 1996;(312):537-539
McBride AA, Romanczuk H, Howley PM. The Papillomavirus E2 Regulatory Proteins. J Biol Chem 1991 Oct. 266(28); 18411-18414
Mino T, Mori T, Aoyama Y, Sera T. Development of protein-based antiviral drugs for human papillomaviruses. Nucleic Acids Symp Ser (Oxf).2007; (51):427-8
Reddout, N. et. al. High Risk HPV types 18 and 16 are potent modulators of oral squamous cell carcinoma phenotypes in vitro. Infect Agent Cancer. 2007 Nov. 14;2(1):21
Stanley, MA. et. al. HPV: From infection to cancer. Biochem Soc Trans. 2007 Dec;35(Pt 6): 1456-60.
Walboomers, JM, Jacobs MV, Manos MM, et. al. Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathology. 1999 Oct. 189(1):12-9
Werness BA, Levine AJ, Howley PM. Association of human papillomavirus types 16
and 18 E6 proteins with p53. Science 1990 Apr 6; 248(4951):76-9.