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Constant Fixation PowerPoint PPT Presentation


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15s. .5s. 6-15 s. 6-15 s. …. …. …. 1000Hz. 1200Hz. Constant Fixation. Controls: N=41, p<1x10 -10. Patients: N=44, p<1x10 -5. MFG, Right Hemisphere, Visit 1. Visit 1. Slice Depth: Y=-36. Controls Patients. Visit 2. MFG, Right Hemisphere, Visit 2. Controls: N=41, p<1x10 -10.

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Constant Fixation

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Constant fixation

15s

.5s

6-15 s

6-15 s

1000Hz

1200Hz

Constant Fixation


Constant fixation

Controls:

N=41, p<1x10-10

Patients:

N=44, p<1x10-5

MFG, Right Hemisphere, Visit 1

Visit 1

Slice Depth: Y=-36

Controls

Patients

Visit 2

MFG, Right Hemisphere, Visit 2


Constant fixation

Controls:

N=41, p<1x10-10

Patients:

N=44, p<1x10-5

MFG, Right Hemisphere, Visit 1

Visit 1

Controls

Patients

Slice Depth: Z=-11

Visit 2

MFG, Right Hemisphere, Visit 2


Constant fixation

STG, Right Hemisphere, Visit 1

Controls:

N=41, p<1x10-10

Patients:

N=44, p<1x10-5

Visit 1

Controls

Patients

Slice Depth: Y=-65

Visit 2

STG, Right Hemisphere, Visit 2


Constant fixation

Controls:

N=41, p<1x10-10

Patients:

N=44, p<1x10-5

STG, Right Hemisphere, Visit 1

Visit 1

Controls

Patients

Slice Depth: Z=-3

Visit 2

STG, Right Hemisphere, Visit 2


Constant fixation

Axial Slices of Brainstem

Averaged Across Populations

and Visits

Z= -12

Inferior

Z= -10

Z= -9

Z= -7

Z= -6

Superior

Z= -4


Time course by visit and diagnosis in mfg

Time-Course by Visit and Diagnosis in MFG


Time course by visit and diagnosis in stg

Time-Course by Visit and Diagnosis in STG


Time course by field in stg

Time-Course by field in STG


Time course by site and field in control stg

Time-Course by Site and Field in Control STG


Intra class correlations

Intra-Class Correlations

Dependent

Variables

Dependent

Variables


Correlation between response to deviants and breath hold in stg controls

Correlation between Response to Deviants and Breath Hold in STG(Controls)

r= .322, p=.003


Correlation between response to deviants and breath hold in stg patients

Correlation between Response to Deviants and Breath Hold in STG(Patients)

r= .246, p= .02


Correlation between response to deviants and breath hold in mfg controls

Correlation between Response to Deviants and Breath Hold in MFG(Controls)

r= .114, p= ns


Correlation between response to deviants and breath hold in mfg patients

Correlation between Response to Deviants and Breath Hold in MFG(Patients)

r= -.041, p= ns


Voxel counts by visit and roi

Voxel Counts by Visit and ROI


Voxel counts by visit

Voxel Counts by Visit


Voxel counts by field

Voxel Counts by Field


Voxel counts by field and roi

Voxel Counts by Field and ROI


Cog wg

Cog WG

Auditory Oddball


Constant fixation

Average STG Signal Change for Diagnostic Group

F = 9.2, p=.003

Control

N = 38

Patient

N = 39


Constant fixation

Average STG Signal Change for Diagnostic Group by Visit

Visit 1

Visit 2

Visit 1

Visit 2

Control

N = 38

Patient

N = 39


Constant fixation

Average STG Signal Change for Auditory Deviants by Field

1.5 T

3.0 T

4.0 T


Constant fixation

Average STG Signal Change for Breath Hold by Field

1.5 T

3.0 T

4.0 T


Constant fixation

Average STG Signal Change By Diagnosis and Field Strength

1.5 T

3.0 T

4.0 T


Constant fixation

Average Hemodynamic Time Series Across ROI

ACG

STG

Thalamus

Visit 1 = BlueVisit 2 = Red


Constant fixation

dlPFC Activation by Auditory Deviants

Controls N=38

Patients N=39


Constant fixation

dlPFC Activation by Auditory Deviants

Controls N=38

Patients N=39

Identical Threshold

Reduced Threshold


Cog wg1

Cog WG

Dual Sternberg MMN Tasks


Dual visual sternberg and auditory mismatch

******

******

18 sec

1

P

1

3

7

4

T

G

Z

R

9

7

5

A

S

V

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

Dual Visual Sternberg and Auditory Mismatch

Rest

Set Size 2

Rest

Set Size 5

A G T Y H

* 1 * 7 *

Repeat

Fixation

Auditory tones: p(1000 Hz) = 0.9, p(1200 Hz) = 0.1

750 ms ISI, 100 ms duration

Visual stimuli: block lengths = 18 sec, ISI = 2000 ms

9 sec of fixation at beginning and end of run


Subjects

Subjects

  • Fifteen healthy subjects (9 females, 6 males; 13 right-handed, 2 left-handed)

  • Age range 18 to 28 years (mean age 21.9 years)

  • All had normal or corrected to normal visual acuity


Constant fixation

Reaction Time by Run for In-Set Probes

Run


Constant fixation

Rest

Low Load

High Load

Activations to Deviant during load conditions (fixed effects)


Constant fixation

High Load

Low Load

Voxels where Load 5 > Load 2, t>=2 (random effects)


Cog wg2

Cog WG

Emotional Oddball Task


Constant fixation

...

...

...

...

...

Emotional Distracter Task

Yamasaki, LaBar, McCarthy, PNAS, 2002


Emotional distracter

Emotional Distracter


Emotional distractor task middle frontal gyrus anterior

Emotional Distractor TaskMiddle Frontal Gyrus (anterior)


Emotional distractor task amygdala

Emotional Distractor TaskAmygdala


Emotional distracter task

Anterior MFG

Posterior IFG

Emotional Distracter Task


Constant fixation

Sad Stimulus Distracter Task


Constant fixation

Sad movies

Happier

Happy movies

Neutral

- Mood +

Sadder

(min)

-4

-2

0

0

2

4

After the movies

Before the movies

Mood Measurement


Constant fixation

Activation of amygdala to sad pictures


Constant fixation

Happy Mood

Sad Mood

0.25

*

Sad stimuli

Sad stimuli

Neutral stimuli

Neutral stimuli

Average of % signal change

0

20

20

-

-

4

4

-

-

2

2

0

0

2

2

4

4

6

6

8

8

10

10

12

12

14

14

16

16

18

18

20

20

-

-

4

4

-

-

2

2

0

0

2

2

4

4

6

6

8

8

10

10

12

12

14

14

16

16

18

18

Time course (s)

-

0.1

Activation of amygdala


Goals for cog challenge group

Goals for Cog Challenge Group

  • Evaluate Phase II SIRP design

    • Did the inclusion of three working memory loads differentiate schizophrenic and control samples?

  • Evaluate Phase II Auditory Oddball task

    • Did temporal lobe activation differentiate schizophrenic and control samples?

  • Cross-task comparisons for Phase II data

    • Were similar patterns of dorsolateral PFC activation observed in both SIRP and Oddball tasks?


Constant fixation

Emotional Distracters and Working Memory

Phase II

Phase I

(14s)

(15s)

Novel stimuli (6s)

+

+

+

3.5s

1.5s

Memoranda

Probe


Constant fixation

MFG

L

R

MR units

IFG

MR units

TR

Scrambled

Neutral

Emotional


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