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15s. .5s. 6-15 s. 6-15 s. …. …. …. 1000Hz. 1200Hz. Constant Fixation. Controls: N=41, p<1x10 -10. Patients: N=44, p<1x10 -5. MFG, Right Hemisphere, Visit 1. Visit 1. Slice Depth: Y=-36. Controls Patients. Visit 2. MFG, Right Hemisphere, Visit 2. Controls: N=41, p<1x10 -10.

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Presentation Transcript
slide1

15s

.5s

6-15 s

6-15 s

1000Hz

1200Hz

Constant Fixation

slide3

Controls:

N=41, p<1x10-10

Patients:

N=44, p<1x10-5

MFG, Right Hemisphere, Visit 1

Visit 1

Slice Depth: Y=-36

Controls

Patients

Visit 2

MFG, Right Hemisphere, Visit 2

slide4

Controls:

N=41, p<1x10-10

Patients:

N=44, p<1x10-5

MFG, Right Hemisphere, Visit 1

Visit 1

Controls

Patients

Slice Depth: Z=-11

Visit 2

MFG, Right Hemisphere, Visit 2

slide5

STG, Right Hemisphere, Visit 1

Controls:

N=41, p<1x10-10

Patients:

N=44, p<1x10-5

Visit 1

Controls

Patients

Slice Depth: Y=-65

Visit 2

STG, Right Hemisphere, Visit 2

slide6

Controls:

N=41, p<1x10-10

Patients:

N=44, p<1x10-5

STG, Right Hemisphere, Visit 1

Visit 1

Controls

Patients

Slice Depth: Z=-3

Visit 2

STG, Right Hemisphere, Visit 2

slide7

Axial Slices of Brainstem

Averaged Across Populations

and Visits

Z= -12

Inferior

Z= -10

Z= -9

Z= -7

Z= -6

Superior

Z= -4

intra class correlations
Intra-Class Correlations

Dependent

Variables

Dependent

Variables

cog wg

Cog WG

Auditory Oddball

slide22

Average STG Signal Change for Diagnostic Group

F = 9.2, p=.003

Control

N = 38

Patient

N = 39

slide23

Average STG Signal Change for Diagnostic Group by Visit

Visit 1

Visit 2

Visit 1

Visit 2

Control

N = 38

Patient

N = 39

slide27

Average Hemodynamic Time Series Across ROI

ACG

STG

Thalamus

Visit 1 = BlueVisit 2 = Red

slide28

dlPFC Activation by Auditory Deviants

Controls N=38

Patients N=39

slide29

dlPFC Activation by Auditory Deviants

Controls N=38

Patients N=39

Identical Threshold

Reduced Threshold

cog wg1

Cog WG

Dual Sternberg MMN Tasks

dual visual sternberg and auditory mismatch

******

******

18 sec

1

P

1

3

7

4

T

G

Z

R

9

7

5

A

S

V

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

Dual Visual Sternberg and Auditory Mismatch

Rest

Set Size 2

Rest

Set Size 5

A G T Y H

* 1 * 7 *

Repeat

Fixation

Auditory tones: p(1000 Hz) = 0.9, p(1200 Hz) = 0.1

750 ms ISI, 100 ms duration

Visual stimuli: block lengths = 18 sec, ISI = 2000 ms

9 sec of fixation at beginning and end of run

subjects
Subjects
  • Fifteen healthy subjects (9 females, 6 males; 13 right-handed, 2 left-handed)
  • Age range 18 to 28 years (mean age 21.9 years)
  • All had normal or corrected to normal visual acuity
slide35

Rest

Low Load

High Load

Activations to Deviant during load conditions (fixed effects)

slide36

High Load

Low Load

Voxels where Load 5 > Load 2, t>=2 (random effects)

cog wg2

Cog WG

Emotional Oddball Task

slide39

...

...

...

...

...

Emotional Distracter Task

Yamasaki, LaBar, McCarthy, PNAS, 2002

slide45

Sad movies

Happier

Happy movies

Neutral

- Mood +

Sadder

(min)

-4

-2

0

0

2

4

After the movies

Before the movies

Mood Measurement

slide47

Happy Mood

Sad Mood

0.25

*

Sad stimuli

Sad stimuli

Neutral stimuli

Neutral stimuli

Average of % signal change

0

20

20

-

-

4

4

-

-

2

2

0

0

2

2

4

4

6

6

8

8

10

10

12

12

14

14

16

16

18

18

20

20

-

-

4

4

-

-

2

2

0

0

2

2

4

4

6

6

8

8

10

10

12

12

14

14

16

16

18

18

Time course (s)

-

0.1

Activation of amygdala

goals for cog challenge group
Goals for Cog Challenge Group
  • Evaluate Phase II SIRP design
    • Did the inclusion of three working memory loads differentiate schizophrenic and control samples?
  • Evaluate Phase II Auditory Oddball task
    • Did temporal lobe activation differentiate schizophrenic and control samples?
  • Cross-task comparisons for Phase II data
    • Were similar patterns of dorsolateral PFC activation observed in both SIRP and Oddball tasks?
slide49

Emotional Distracters and Working Memory

Phase II

Phase I

(14s)

(15s)

Novel stimuli (6s)

+

+

+

3.5s

1.5s

Memoranda

Probe

slide50

MFG

L

R

MR units

IFG

MR units

TR

Scrambled

Neutral

Emotional

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