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Introduction. use for more than half a centurythe treatment of choice for most young people with Graves\' disease. Mechanism of Action . simple molecules :thionamides, contain a sulfhydryl group and a thiourea moiety within a heterocyclic structure Propylthiouracil and methimazole: United StatesMethimazole: Europe and AsiaCarbimazole: United Kingdom actively concentrated by thyroid gland against a concentration gradient.inhibit thyroid hormone synthesis by interfering with thyroid peroxid30777

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