Dox Tablets (Generic Doxycycline Hydrochloride Tablets)

1. Dox Tablets (Generic Doxycycline Tablets) © The Swiss Pharmacy

2. Dox Tablets (Generic Doxycycline Tablets) Dox Tablets (Generic Doxycycline Hydrochloride tablets) are tetracycline class medicines which are used for Rickettsial infections, Sexually transmitted infections, Respiratory tract infections, Specific bacterial infections, Ophthalmic infections, Anthrax, including inhalational anthrax (post-exposure). Doxycycline tablets are also used as an alternative treatment for selected infections when penicillin is contraindicated as an adjunctive therapy for acute intestinal amebiasis and severe acne and for the prophylaxis of malaria. © The Swiss Pharmacy

3. Dox Tablets (Generic Doxycycline Tablets) Dox Tablets are manufactured by SGS Pharmaceuticals Private Limited, India in the strength of 100 mg. © The Swiss Pharmacy

4. Dox Tablets (Generic Doxycycline Tablets) Chemical Structure © The Swiss Pharmacy

5. Dox Tablets (Generic Doxycycline Tablets) The active ingredient contained in Dox tablets is Doxycycline Hydrochloride. Each film-coated Dox tablet contains Doxycycline Hydrochloride equivalent to 100 mg of Doxycycline. © The Swiss Pharmacy

6. Dox Tablets (Generic Doxycycline Tablets) Uses of Dox 100 mg Tablets: Dox (Generic Doxycycline Tablets) is used to treat bacterial infections in many different parts of the body. It is also used to treat pimples and abscesses (usually on the face) that are caused by rosacea, also known as acne rosacea or adult acne. Doxycycline tablets are also used to prevent malaria and treat anthrax infection after possible exposure and other conditions as determined by your doctor. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9892_Doxycycline-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9892_Doxycycline-Tablets.html © The Swiss Pharmacy

7. Dox Tablets (Generic Doxycycline Tablets) Uses of Dox 100 mg Tablets: Doxycycline (Doxycycline Hydrochloride 100 mg Tablets) belongs to the class of medicines known as tetracycline antibiotics. It works by killing bacteria or preventing their growth. It may be used to treat a wide range of infections caused by bacteria, these include: Chest, lung or nasal infections e.g. bronchitis, pneumonia, sinusitis Infections of the kidneys and bladder e.g. cystitis, urethritis Infections of the skin such as acne Eye infections Sexually transmitted diseases e.g. gonorrhoea, syphilis, chlamydia URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9892_Doxycycline-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9892_Doxycycline-Tablets.html © The Swiss Pharmacy

8. Dox Tablets (Generic Doxycycline Tablets) Uses of Dox 100 mg Tablets: Rickettsial infections such as Q fever or fevers associated with louse or tick bites Malaria, when chloroquine is not effective. Other infections such as cholera, brucellosis, leptospirosis and psittacosis Doxycycline tablets are also used to prevent certain infections developing such as scrub typhus, travellers’ diarrhoea, malaria and leptospirosis (a bacterial infection caused by exposure to bacteria in fresh water contaminated by animal urine). URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9892_Doxycycline-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9892_Doxycycline-Tablets.html © The Swiss Pharmacy

9. Dox Tablets (Generic Doxycycline Tablets) Recommended Adult Dosage For most adult patients, the dose of Dox Tablets (Doxycycline Hydrochloride Tablets) is 200 mg on the first day of treatment (administered 100 mg every 12 hours) followed by a maintenance dose of 100 mg/day. In the management of more severe infections (particularly chronic infections of the urinary tract), 100 mg every 12 hours is recommended. Dox Tablets URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9892_Doxycycline-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9892_Doxycycline-Tablets.html © The Swiss Pharmacy

10. Dox Tablets (Generic Doxycycline Tablets) Recommended Adult Dosage For children above eight years of age the recommended dosage schedule for children weighing 100 pounds or less is 2 mg/lb of body weight divided into two doses on the first day of treatment, followed by 1 mg/lb of body weight given as a single daily dose or divided into two doses on subsequent days. For more severe infections up to 2 mg/lb of body weight may be used. For children over 100 lb, the usual adult dose should be used. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9892_Doxycycline-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9892_Doxycycline-Tablets.html © The Swiss Pharmacy

11. Dox Tablets (Generic Doxycycline Tablets) Contraindications ➔Dox is contraindicated in patients with a known hypersensitivity to Doxycycline Hydrochloride, any of the tetracyclines or any component of the tablet. ➔Administration of Dox is contraindicated in pregnancy ➔Tetracyclines are excreted into milk and are therefore contraindicated in nursing mothers URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9892_Doxycycline-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9892_Doxycycline-Tablets.html © The Swiss Pharmacy

12. Dox Tablets (Generic Doxycycline Tablets) Contraindications ➔Sucrose intolerance: Patients with rare hereditary problems of fructose intolerance, glucose galactose malabsorption or sucrose-isomaltase insufficiency should not take Doxycycline Hydrochloride tablets (Dox). URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9892_Doxycycline-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9892_Doxycycline-Tablets.html © The Swiss Pharmacy

13. Dox Tablets (Generic Doxycycline Tablets) Storage Instructions Dox Tablets (Generic Doxycycline Tablets) have to be stored at controlled room temperature i.e. from 20°C to 25°C (68°F to 77°F) with excursions permitted between 15° to 30°C (59° to 86°F). Keep this as well as all other medicines away from children and pets. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9892_Doxycycline-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9892_Doxycycline-Tablets.html © The Swiss Pharmacy

14. Dox Tablets (Generic Doxycycline Tablets) Warnings The use of medicines of the Tetracycline class like Dox during tooth development (last half of pregnancy, infancy and childhood to the age of 8 years) may cause permanent discoloration of the teeth (yellow-gray-brown). Clostridium difficile-associated diarrhea: Evaluate patients in case diarrhea occurs. Photosensitivity manifested by an exaggerated sunburn reaction has been observed in some patients taking Tetracyclines. Limit sun exposure in patients. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9892_Doxycycline-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9892_Doxycycline-Tablets.html © The Swiss Pharmacy

15. Dox Tablets (Generic Doxycycline Tablets) Warnings Overgrowth of non-susceptible organisms, including fungi, may occur. Re evaluate therapy if superinfection occurs. Doxycycline should be administered with caution to patients with hepatic impairment or those receiving potentially hepatotoxic drugs. Excretion of doxycycline by the kidney is about 40%/72 hours in individuals with normal renal function. This percentage excretion may fall to a range as low as 1-5%/72 hours in individuals with severe renal insufficiency (creatinine clearance below 10ml/min). URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9892_Doxycycline-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9892_Doxycycline-Tablets.html © The Swiss Pharmacy

16. Dox Tablets (Generic Doxycycline Tablets) Warnings Instances of oesophagitis and oesophageal ulcerations have been reported in patients receiving capsule and tablet forms of drugs in the tetracycline class, including doxycycline. Bulging fontanelles in infants and benign intracranial hypertension in juveniles and adults have been reported in individuals receiving full therapeutic dosages. These conditions disappeared rapidly when the drug was discontinued. There have been rare reports of porphyria in patients receiving tetracyclines. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9892_Doxycycline-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9892_Doxycycline-Tablets.html © The Swiss Pharmacy

17. Dox Tablets (Generic Doxycycline Tablets) Warnings When treating venereal disease, where co-existent syphilis is suspected, proper diagnostic procedures, including dark-field examinations, should be utilized. Infections due to Group A beta-haemolytic streptococci should be treated for at least 10 days. Due to a potential for weak neuromuscular blockade, care should be taken in administering tetracyclines to patients with myasthenia gravis. Tetracyclines can cause exacerbation of systemic lupus erythematosus (SLE). URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9892_Doxycycline-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9892_Doxycycline-Tablets.html © The Swiss Pharmacy

18. Dox Tablets (Generic Doxycycline Tablets) Warnings Some patients with spirochete infections may experience a Jarisch-Herxheimer reaction shortly after doxycycline treatment is started. Patients should be reassured that this is a usually self- limiting consequence of antibiotic treatment of spirochete infections. Caution is advised in administering Tetracyclines with Methoxyflurane. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9892_Doxycycline-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9892_Doxycycline-Tablets.html © The Swiss Pharmacy

19. Dox Tablets (Generic Doxycycline Tablets) Effects On Ability To Drive And Use Machines Visual disturbances such as blurring of vision may occur during treatment with Doxycycline Hydrochloride tablets (Dox) and in such cases; patients must refrain from driving or operating machinery. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9892_Doxycycline-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9892_Doxycycline-Tablets.html © The Swiss Pharmacy

20. Dox Tablets (Generic Doxycycline Tablets) Dox Tablets and Alcohol Mixing Doxycycline and alcohol won't cause any serious health issues. But drinking enough alcohol to get to the point of feeling drunk can affect your recovery. It's best not to drink alcohol with Doxycycline because it can stop it working properly. Speak to your doctor or pharmacist if you have questions about this. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9892_Doxycycline-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9892_Doxycycline-Tablets.html © The Swiss Pharmacy

21. Dox Tablets (Generic Doxycycline Tablets) Possible Side Effects Side effects observed in patients receiving tetracyclines like Dox (Generic Doxycycline Hydrochloride 100 mg Tablets) include anorexia, nausea, vomiting, diarrhea, rash, photosensitivity, urticaria, and hemolytic anemia. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9892_Doxycycline-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9892_Doxycycline-Tablets.html © The Swiss Pharmacy

22. Dox Tablets (Generic Doxycycline Tablets) Possible Side Effects The following side effects have been identified during post-marketing use of Doxycycline tablets (Dox): Gastrointestinal: Anorexia, nausea, vomiting, diarrhea, glossitis, dysphagia, enterocolitis, and inflammatory lesions (with monilial overgrowth) in the anogenital region. Hepatotoxicity has been reported. Esophagitis and esophageal ulcerations have been reported in patients receiving capsule and tablet forms of medicines in the tetracycline-class. Most of these patients took medications immediately before going to bed. Skin: Maculopapular and erythematous rashes, Stevens-Johnson syndrome, toxic epi- dermal necrolysis, exfoliative dermatitis, and erythema multiforme have been reported. Renal: Rise in BUN has been reported and is apparently dose-related Hypersensitivity Reactions: Urticaria, angioneurotic edema, anaphylaxis, anaphylactoid purpura, serum sickness, pericarditis, and exacerbation of systemic lupus erythematosus. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9892_Doxycycline-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9892_Doxycycline-Tablets.html © The Swiss Pharmacy

23. Dox Tablets (Generic Doxycycline Tablets) Possible Side Effects The following side effects have been identified during post-marketing use of Doxycycline tablets (Dox): Blood: Hemolytic anemia, thrombocytopenia, neutropenia, and eosinophilia have been reported. Intracranial Hypertension: Intracranial hypertension (IH, pseudotumor cerebri) has been associated with the use of tetracycline Thyroid Gland Changes: When given over prolonged periods, tetracyclines have beenreported to produce brown-black microscopic discoloration of thyroid glands. No abnormalities of thyroid function are known to occur. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9892_Doxycycline-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9892_Doxycycline-Tablets.html © The Swiss Pharmacy

24. Dox Tablets (Generic Doxycycline Tablets) Dox Tablets Overdosage In case of overdosage, discontinue medication, treat symptomatically and institute supportive measures. Dialysis does not alter serum half-life and thus would not be of benefit in treating cases of Dox overdosage. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9892_Doxycycline-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9892_Doxycycline-Tablets.html © The Swiss Pharmacy

25. Dox Tablets (Generic Doxycycline Tablets) Dox Tablets During Pregnancy Doxycycline Hydrochloride (Dox Tablets) has been classified by the US FDA as Pregnancy Category D. There are no adequate and well-controlled studies on the use of Doxycycline in pregnant women. The vast majority of reported experience with Doxycycline during human pregnancy is short-term, first trimester exposure. There are no human data available to assess the effects of long-term therapy of doxycycline in pregnant women such as that proposed for the treatment of anthrax exposure. An expert review of published data on experiences with Doxycycline use during pregnancy by TERIS - the Teratogen Information System - concluded that therapeutic doses during pregnancy are unlikely to pose a substantial teratogenic risk (the quantity and quality of data were assessed as limited to fair), but the data are insufficient to state that there is no risk. © The Swiss Pharmacy

26. Dox Tablets (Generic Doxycycline Tablets) Dox Tablets During Nursing Tetracyclines are excreted in human milk, however, the extent of absorption of tetracyclines including Doxycycline (Dox tablets), by the breastfed infant is not known. Short-term use by lactating women is not necessarily contraindicated. The effects of prolonged exposure to doxycycline in breast milk are unknown. Because of the potential for serious adverse reactions in nursing infants from doxycycline, a decision should be made whether to discontinue nursing or to discontinue Doxycycline Hydrochloride (Dox Tablets), taking into account the importance of the drug to the mother. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9892_Doxycycline-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9892_Doxycycline-Tablets.html © The Swiss Pharmacy

27. Dox Tablets (Generic Doxycycline Tablets) Dox Tablets Dox Tablets (Generic Doxycycline Tablets) are manufactured by SGS Pharmaceuticals Private Limited, India. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9892_Doxycycline-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9892_Doxycycline-Tablets.html © The Swiss Pharmacy