Armotraz Tablets (Generic Anastrozole Tablets)

1. Armotraz Tablets (Generic Anastrozole Tablets) © The Swiss Pharmacy

2. Armotraz Tablets (Generic Anastrozole Tablets) Armotraz (Generic Anastrozole 1 mg Tablets) is an aromatase inhibitor which is used for adjuvant treatment of postmenopausal women with hormone receptor-positive early breast cancer. They are also used for first-line treatment of postmenopausal women with hormone receptor-positive or hormone receptor unknown locally advanced or metastatic breast cancer and for the treatment of advanced breast cancer in postmenopausal women with disease progression following Tamoxifen therapy. © The Swiss Pharmacy

3. Armotraz Tablets (Generic Anastrozole Tablets) Armotraz Tablets are manufactured by Cipla Limited, India in the strength of 1 mg. © The Swiss Pharmacy

4. Armotraz Tablets (Generic Anastrozole Tablets) Chemical Structure © The Swiss Pharmacy

5. Armotraz Tablets (Generic Anastrozole Tablets) The active ingredient contained in Armotraz tablets is Anastrozole. Each film-coated Armotraz tablet contains 1 mg of Anastrozole. © The Swiss Pharmacy

6. Armotraz Tablets (Generic Anastrozole Tablets) Uses of Armotraz 1 mg Tablets: Armotraz contains an ingredient called Anastrozole. This belongs to a group of medicines called 'aromatase inhibitors'. Armotraz is used to treat breast cancer in women who have gone through the menopause. This medicine is used to treat the following indications: Adjuvant treatment of postmenopausal women with hormone receptor- positive early breast cancer. First-line treatment of postmenopausal women with hormone receptor- positive or hormone receptor unknown locally advanced or metastatic breast cancer. Treatment of advanced breast cancer in postmenopausal women with disease progression following Tamoxifen therapy. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9896_Anastrozole-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9896_Anastrozole-Tablets.html © The Swiss Pharmacy

7. Armotraz Tablets (Generic Anastrozole Tablets) Uses of Armotraz 1 mg Tablets: Many breast cancer tumors grow in response to estrogen. This medicine interferes with the production of estrogen in the body. As a result, the amount of estrogen that the tumor is exposed to is reduced, limiting the growth of the tumor. Patients with ER-negative disease and patients who did not respond to previous Tamoxifen therapy rarely responded to Armotraz tablets. Anastrozole tablets works by cutting down the amount of the hormone called estrogen that your body makes. It does this by blocking a natural substance (an enzyme) in your body called ‘aromatase’. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9896_Anastrozole-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9896_Anastrozole-Tablets.html © The Swiss Pharmacy

8. Armotraz Tablets (Generic Anastrozole Tablets) Uses of Armotraz 1 mg Tablets in Bodybuilding (Off-Label): Some bodybuilders take Anastrozole to reduce the side effects of anabolic steroids. The drug is a breast cancer treatment that lowers estrogen levels and should not be used for other means. Bodybuilders who take anabolic steroids to try to increase muscle mass and improve athletic performance can experience a range of symptoms. In some cases, males might start to grow breasts due to an increase in estrogen levels. Anastrozole lowers estrogen levels and can prevent breast growth in males. Anastrozole stops aromatase from working in the body. Aromatase is an enzyme that makes estrogen from steroid hormones, including testosterone. By doing this, it lowers the amount of estrogen in the body. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9896_Anastrozole-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9896_Anastrozole-Tablets.html © The Swiss Pharmacy

9. Armotraz Tablets (Generic Anastrozole Tablets) Recommended Adult Dosage The dose of Armotraz Tablets Armotraz Tablets (Generic Anastrozole Tablets) is one 1 mg tablet taken once a day. For patients with advanced breast cancer, Armotraz Tablets should be continued until tumour progression. Armotraz Tablets can be taken with or without food. For adjuvant treatment of early breast cancer in postmenopausal women, the optimal duration of therapy is unknown. In the ATAC (the Anastrozole, Tamoxifen, Alone or in Combination study) trial, Anastrozole was administered for 5 years. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9896_Anastrozole-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9896_Anastrozole-Tablets.html © The Swiss Pharmacy

10. Armotraz Tablets (Generic Anastrozole Tablets) Recommended Adult Dosage Anastrozole tablets are not recommended for use in children and adolescents due to insufficient data on safety and efficacy. No dosage adjustment is necessary for elderly patients. No changes in dose are recommended for patients with mild-to-moderate hepatic impairment. Anastrozole tablets have not been studied in patients with severe hepatic impairment. Anastrozole is not recommended for use in children and adolescents due to insufficient data on safety and efficacy. No dosage adjustment is necessary for elderly patients. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9896_Anastrozole-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9896_Anastrozole-Tablets.html © The Swiss Pharmacy

11. Armotraz Tablets (Generic Anastrozole Tablets) Recommended Adult Dosage Armotraz (Anastrozole tablets) may be used by bodybuilders to block estrogen. Armotraz may help prevent side effects such as gynecomastia (male breast enlargement) from developing due to the aromatization of anabolic steroids. When used for this purpose, Anastrozole (Armotraz tablets) is typically introduced in week two of the cycle and taken for the entire length of the cycle at 0.5 mg twice a week. Anastrozole (Armotraz tablets) is only approved by the Food and Drug Anastrozole (Armotraz tablets) is only approved by the Food and Drug Administration (FDA) for use in breast cancer treatment. Administration (FDA) for use in breast cancer treatment. There are no formal guidelines for its use in bodybuilding. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9896_Anastrozole-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9896_Anastrozole-Tablets.html © The Swiss Pharmacy

12. Armotraz Tablets (Generic Anastrozole Tablets) Contraindications ➔Armotraz tablets are contraindicated in any patient who has shown a hypersensitivity reaction to Anastrozole or to any of the inactive ingredients present in Anastrozole tablets. Observed reactions include anaphylaxis, angioedema, and urticaria. ➔Armotraz tablets may cause fetal harm when administered to a pregnant woman and offers no clinical benefit to premenopausal women with breast cancer. ➔Armotraz (Anastrozole Tablets) is contraindicated in women of premenopausal endocrine status, including pregnant women. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9896_Anastrozole-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9896_Anastrozole-Tablets.html © The Swiss Pharmacy

13. Armotraz Tablets (Generic Anastrozole Tablets) Storage Instructions Armotraz Tablets (Generic Anastrozole Tablets) have to be stored at controlled room temperature i.e. from 20°C to 25°C (68°F to 77°F) with excursions permitted between 15° to 30°C (59° to 86°F). Keep this as well as all other medicines away from children and pets. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9896_Anastrozole-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9896_Anastrozole-Tablets.html © The Swiss Pharmacy

14. Armotraz Tablets (Generic Anastrozole Tablets) Warnings In women with pre-existing ischemic heart disease, an increased incidence of ischemic cardiovascular events occurred with Anastrozole Tablets (Armotraz) use compared to Tamoxifen use. Consider risks and benefits. Decreases in bone mineral density may occur. As Anastrozole lowers circulating estrogen levels it may cause a reduction in bone mineral density with a possible consequent increased risk of fracture. Consider bone mineral density monitoring. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9896_Anastrozole-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9896_Anastrozole-Tablets.html © The Swiss Pharmacy

15. Armotraz Tablets (Generic Anastrozole Tablets) Warnings Increases in total cholesterol may occur. Consider cholesterol monitoring. Anastrozole should not be used in premenopausal women. Anastrozole has not been investigated in breast cancer patients with moderate or severe hepatic impairment. Exposure to Anastrozole can be increased in subjects with hepatic impairment. Administration of Armotraz in patients with moderate and severe hepatic impairment should be performed with caution. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9896_Anastrozole-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9896_Anastrozole-Tablets.html © The Swiss Pharmacy

16. Armotraz Tablets (Generic Anastrozole Tablets) Warnings Anastrozole has not been investigated in breast cancer patients with severe renal impairment. In patients with severe renal impairment, administration of Armotraz should be performed with caution. Armotraz is not recommended for use in children and adolescents as safety and efficacy have not been established in this group of patients. This product contains lactose. Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose- galactose malabsorption should not take Armotraz tablets. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9896_Anastrozole-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9896_Anastrozole-Tablets.html © The Swiss Pharmacy

17. Armotraz Tablets (Generic Anastrozole Tablets) Warnings Anastrozole is not recommended for use in children and adolescents as safety and efficacy have not been established in this group of patients. Anastrozole should not be used in boys with growth hormone deficiency in addition to growth hormone treatment. In the pivotal clinical trial, efficacy was not demonstrated and safety was not established. Since Anastrozole (Armotraz Tablets) reduces estradiol levels, Anastrozole tablets must not be used in girls with growth hormone deficiency in addition to growth hormone treatment. Long-term safety data in children and adolescents are not available. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9896_Anastrozole-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9896_Anastrozole-Tablets.html © The Swiss Pharmacy

18. Armotraz Tablets (Generic Anastrozole Tablets) Possible Side Effects In the early breast cancer (ATAC) study, the most common (occurring with an incidence of more than 10%) side effects occurring in women taking Anastrozole tablets (Armotraz) included: hot flashes, asthenia, arthritis, pain, arthralgia, pharyngitis, hypertension, depression, nausea and vomiting, rash, osteoporosis, fractures, back pain, insomnia, headache, peripheral edema and lymphedema, regardless of causality. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9896_Anastrozole-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9896_Anastrozole-Tablets.html © The Swiss Pharmacy

19. Armotraz Tablets (Generic Anastrozole Tablets) Possible Side Effects In the advanced breast cancer studies, the most common (occurring with an incidence of greater than 10%) side effects occurring in women taking Anastrozole tablets (Armotraz) included: hot flashes, nausea, asthenia, pain, headache, back pain, bone pain, increased cough, dyspnea, pharyngitis and peripheral edema. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9896_Anastrozole-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9896_Anastrozole-Tablets.html © The Swiss Pharmacy

20. Armotraz Tablets (Generic Anastrozole Tablets) Armotraz Tablets Overdosage Clinical trials have been conducted with Anastrozole (Armotraz Tablets) tablets, up to 60 mg in a single dose given to healthy male volunteers and up to 10 mg daily given to postmenopausal women with advanced breast cancer; these dosages were tolerated. A single dose of Anastrozole that results in life-threatening symptoms has not been established. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9896_Anastrozole-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9896_Anastrozole-Tablets.html © The Swiss Pharmacy

21. Armotraz Tablets (Generic Anastrozole Tablets) Treatment of Armotraz Tablets Overdosage There is no specific antidote to Anastrozole (Armotraz Tablets) overdosage and treatment must be symptomatic. In the management of an overdose, consider that multiple agents may have been taken. Vomiting may be induced if the patient is alert. Dialysis may be helpful because Anastrozole is not highly protein bound. General supportive care, including frequent monitoring of vital signs and close observation of the patient, is indicated. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9896_Anastrozole-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9896_Anastrozole-Tablets.html © The Swiss Pharmacy

22. Armotraz Tablets (Generic Anastrozole Tablets) Armotraz Tablets During Pregnancy Anastrozole (Armotraz tablets) has been classified by the US FDA as Pregnancy Category X. Anastrozole (Armotraz tablets) may cause fetal harm when administered to a pregnant woman and offers no clinical benefit to premenopausal women with breast cancer. Anastrozole is contraindicated in women who are or may become pregnant. In animal studies, Anastrozole tablets caused pregnancy failure, increased pregnancy loss, and signs of delayed fetal development. There are no studies of Anastrozole use in pregnant women. In case Anastrozole (Armotraz tablets) is used during pregnancy, or if the patient becomes pregnant while receiving this drug, the patient should be apprised of the potential hazard to the fetus and potential risk for pregnancy loss. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9896_Anastrozole-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9896_Anastrozole-Tablets.html © The Swiss Pharmacy

23. Armotraz Tablets (Generic Anastrozole Tablets) Armotraz Tablets Armotraz Tablets (Generic Anastrozole Tablets) are manufactured by Cipla Limited, India. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9896_Anastrozole-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9896_Anastrozole-Tablets.html © The Swiss Pharmacy