Antidep Tablets (Generic Imipramine Hydrochloride Tablets)

1. Antidep Tablets (Generic Imipramine Hydrochloride Tablets) © The Swiss Pharmacy

2. Antidep Tablets (Generic Imipramine Hydrochloride Tablets) Antidep (Generic Imipramine Hydrochloride Tablets) is used for the relief of symptoms of depression. Using this medication to treat depression may improve your mood, sleep, appetite, and energy level and may help restore your interest in daily living. This medicine may be useful as temporary adjunctive therapy in reducing enuresis in children aged 6 years and older, after possible organic causes have been excluded by appropriate tests. © The Swiss Pharmacy

3. Antidep Tablets (Generic Imipramine Hydrochloride Tablets) Antidep Tablets are manufactured by Torrent Pharmaceuticals Limited, India in the strengths of 25 mg and 75 mg. © The Swiss Pharmacy

4. Antidep Tablets (Generic Imipramine Hydrochloride Tablets) Chemical Structure © The Swiss Pharmacy

5. Antidep Tablets (Generic Imipramine Hydrochloride Tablets) The active ingredient contained in Antidep tablets is Imipramine Hydrochloride. Each Antidep tablet contains 25 mg or 75 mg of Imipramine Hydrochloride. © The Swiss Pharmacy

6. Antidep Tablets (Generic Imipramine Hydrochloride Tablets) Uses of Antidep 25 mg and 75 mg Tablets: Antidep (Generic Imipramine Hydrochloride Tablets) is a tricyclic antidepressant used to treat symptoms of depression. These medicines are thought to work by increasing the activity of a chemical called serotonin in the brain. Endogenous depression is more likely to be alleviated than other depressive states. One to three weeks of treatment may be needed before optimal therapeutic effects are evident. Using this medication to treat depression may improve your mood, sleep, appetite, and energy level and may help restore your interest in daily living. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9636_Imipramine-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9636_Imipramine-Tablets.html © The Swiss Pharmacy

7. Antidep Tablets (Generic Imipramine Hydrochloride Tablets) Uses of Antidep 25 mg and 75 mg Tablets: Imipramine is sometimes used to treat bed-wetting in children ages 6 and older after possible organic causes have been excluded by appropriate tests. In patients having daytime symptoms of frequency and urgency, examination should include voiding cystourethrography and cystoscopy, as necessary. The effectiveness of treatment may decrease with continued drug administration. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9636_Imipramine-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9636_Imipramine-Tablets.html © The Swiss Pharmacy

8. Antidep Tablets (Generic Imipramine Hydrochloride Tablets) Recommended Adult Dosage Depression: For most patients (except in elderly patients, adolescents or children), the starting dose of Antidep Tablets (Generic Imipramine Tablets) is 25 mg 3 times daily, initially, increased up to 150 mg daily, if necessary. Dosage in excess of 200 mg daily is not recommended for outpatients. More severe, hospitalized cases may require up to 300 mg daily. Depression: Antidep Tablets In Elderly Patients and Adolescents: 30 to 40 mg daily, initially, increased by 10 mg daily to a maximum of 100 mg in the elderly. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9636_Imipramine-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9636_Imipramine-Tablets.html © The Swiss Pharmacy

9. Antidep Tablets (Generic Imipramine Hydrochloride Tablets) Recommended Adult Dosage Childhood Enuresis: Childhood Enuresis: Initially, an oral dose of 25 mg/day should be tried in children aged 6 and older. Medication should be given one hour before bedtime. If a satisfactory response does not occur within one week, increase the dose to 50 mg nightly in children under 12 years; children over 12 may receive up to 75 mg nightly. A daily dose greater than 75 mg does not enhance efficacy and tends to increase side effects. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9636_Imipramine-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9636_Imipramine-Tablets.html © The Swiss Pharmacy

10. Antidep Tablets (Generic Imipramine Hydrochloride Tablets) Contraindications ➔Antidep tablets are contraindicated in patients with a known hypersensitivity to Imipramine Hydrochloride or any component of the tablet. The possibility of cross-sensitivity to other Dibenzazepine compounds should be kept in mind. ➔The concomitant use of monoamine oxidase inhibiting compounds is contraindicated. Hyperpyretic crises or severe convulsive seizures may occur in patients receiving such combinations. The potentiation of adverse effects can be serious, or even fatal. When it is desired to substitute imipramine hydrochloride in patients receiving a monoamine oxidase inhibitor, as long an interval should elapse as the clinical situation will allow, with a minimum of 14 days. Initial dosage should be low and increases should be gradual and cautiously prescribed. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9636_Imipramine-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9636_Imipramine-Tablets.html © The Swiss Pharmacy

11. Antidep Tablets (Generic Imipramine Hydrochloride Tablets) Contraindications ➔Antidep tablets are contraindicated in during the acute recovery period after a myocardial infarction. ➔This medicine is contraindicated in patients with Prostatic hyperplasia, pyloric stenosis and other stenoses of the gastrointestinal and genitourinary systems, liver diseases and confirmed or suspected pregnancy and breast-feeding. ➔Antidep is contraindicated for the treatment of depression in patients 18 years of age and under. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9636_Imipramine-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9636_Imipramine-Tablets.html © The Swiss Pharmacy

12. Antidep Tablets (Generic Imipramine Hydrochloride Tablets) Storage Instructions Antidep Tablets (Generic Imipramine Hydrochloride Tablets) have to be stored at controlled room temperature i.e. from 20°C to 25°C (68°F to 77°F) with excursions permitted between 15° to 30°C (59° to 86°F). Keep this as well as all other medicines away from children and pets. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9636_Imipramine-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9636_Imipramine-Tablets.html © The Swiss Pharmacy

13. Antidep Tablets (Generic Imipramine Hydrochloride Tablets) Warnings Patients with major depressive disorder (MDD), both adult and pediatric, may experience worsening of their depression and/or the emergence of suicidal ideation and behavior (suicidality) or unusual changes in behavior, whether or not they are taking antidepressant medications, and this risk may persist until significant remission occurs. A major depressive episode may be the initial presentation of bipolar disorder. It is generally believed (though not established in controlled trials) that treating such an episode with an antidepressant alone may increase the likelihood of precipitation of a mixed/manic episode in patients at risk for bipolar disorder. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9636_Imipramine-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9636_Imipramine-Tablets.html © The Swiss Pharmacy

14. Antidep Tablets (Generic Imipramine Hydrochloride Tablets) Warnings The pupillary dilation that occurs following use of many antidepressant drugs including imipramine hydrochloride may trigger an angle-closure attack in a patient with anatomically narrow angles who does not have a patent iridectomy. A dose of 2.5 mg/kg/day of imipramine hydrochloride should not be exceeded in childhood. ECG changes of unknown significance have been reported in pediatric patients with doses twice this amount. Extreme caution should be used when Antidep (Generic Imipramine Hydrochloride Tablets) is given to patients with cardiovascular disease, patients with history of urinary retention, hyperthyroid patients or those on thyroid medication, patients with a history of seizure disorder, patients receiving Guanethidine, Clonidine, or similar agents and patients receiving Methylphenidate Hydrochloride. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9636_Imipramine-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9636_Imipramine-Tablets.html © The Swiss Pharmacy

15. Antidep Tablets (Generic Imipramine Hydrochloride Tablets) Warnings An ECG recording should be taken prior to the initiation of larger-than-usual doses of imipramine hydrochloride and at appropriate intervals thereafter until steady state is achieved. Patients with any evidence of cardiovascular disease require cardiac surveillance at all dosage levels of the drug. Imipramine may enhance the CNS depressant effects of alcohol. Therefore, it should be borne in mind that the dangers inherent in a suicide attempt or accidental overdosage with the medicine may be increased for the patient who uses excessive amounts of alcohol. Since Imipramine Hydrochloride may impair the mental and/or physical abilities required for the performance of potentially hazardous tasks, such as operating an automobile or machinery, the patient should be cautioned accordingly. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9636_Imipramine-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9636_Imipramine-Tablets.html © The Swiss Pharmacy

16. Antidep Tablets (Generic Imipramine Hydrochloride Tablets) Possible Side Effects Infection And Infestations: Very rare: dental caries Neurological: Very common: tremors. Common: dizziness, headache, paresthesia (numbness, tingling sensation, symptoms suggestive of peripheral neuropathy) , delirium. Rare: convulsions. Very rare: tinnitus, incoordination, ataxia, electroencephalogram abnormal, extra pyramidal disorder, myoclonus, speech disorders, asthenia. Behavioral: Common: somnolence, fatigue, insomnia, confusional states with hallucinations, anxiety, agitation, restlessness, nightmares, hypomania, mania, decrease in memory, feeling of unreality, disorientation. Rare: psychotic disorders. Very rare: aggression. Anticholinergic: Very common: dry mouth and rarely associated sublingual adenitis, blurred vision, disturbances of visual accommodation, lacrimation decreased, constipation, hyperhidrosis, hotflushes. Common: micturition disorders, dilation of the urinary tract. Very rare: mydriasis, glaucoma, paralytic ileus, urinary retention. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9636_Imipramine-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9636_Imipramine-Tablets.html © The Swiss Pharmacy

17. Antidep Tablets (Generic Imipramine Hydrochloride Tablets) Possible Side Effects Cardiovascular: Very common: hypotension, particularly orthostatic hypotension with associated vertigo, sinus tachycardia, electrocardiogram abnormalities. Common: arrhythmia,disturbances in cardiac conduction, palpitation, syncope. Very rare: hypertension, congestive heart failure, myocardial infarction, heart block, asystole, stroke, vasospams, QT interval prolongation, ventricular arrhythmia, ventricular tachycardia, ventricular fibrillation, torsades de pointes. Hematologic: Very rare: agranulocytosis, eosinophilia, leukopenia, purpura and thrombocytopenia may occur as an idiosyncratic response. Gastrointestinal: Common: nausea, vomiting, anorexia, abdominal cramps, liver function test abnormal. Rare: diarrhea. Very rare: bitter taste, stomatitis, epigastric distress, black tongue, dysphagia, increased salivation, hepatitis with or without jaundice, abdominal disorders, tongue ulceration. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9636_Imipramine-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9636_Imipramine-Tablets.html © The Swiss Pharmacy

18. Antidep Tablets (Generic Imipramine Hydrochloride Tablets) Possible Side Effects Respiratory: Very rare: bronchospasm. Endocrine: Very common: Weight gain. Common: increased or decreased libido, impotence. Very rare: gynecomastia in the male, hypertrophy breast and galactorrhea in the female, testicular swelling, elevation or depression of blood sugar levels, weight loss, inappropriate antidiuretic hormone (SIADH) secretion syndrome. Allergic or toxic: Common:dermatitis allergic, rash, urticaria, Very rare: petechiae, itching, photo sensitization,edema, pyrexia, obstructive jaundice, nasal congestion,alopecia, cross-sensitivity with desipramine, allergical veolitis (pneumonia) with or without eosinophilia, systemic anaphylactic / anaphylactoid reactions including hypotension, skin hyperpigmentation. General disorders: Very rare: sudden death URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9636_Imipramine-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9636_Imipramine-Tablets.html © The Swiss Pharmacy

19. Antidep Tablets (Generic Imipramine Hydrochloride Tablets) Antidep Tablets Overdosage Overdose symptoms may vary in severity depending upon factors such as the amount of drug absorbed, the age of the patient, and the interval between drug ingestion and the start of treatment. Critical manifestations of overdose include cardiac dysrhythmias, severe hypotension, convulsions, and CNS depression including coma. Changes in the electrocardiogram, particularly in QRS axis or width, are clinically significant indicators of tricyclic toxicity. Other CNS manifestations may include drowsiness, stupor, ataxia, restlessness, agitation, hyperactive reflexes, muscle rigidity, athetoid and choreiform movements. Cardiac abnormalities may include tachycardia and signs of congestive failure. Respiratory depression, cyanosis, shock, vomiting, hyperpyrexia, mydriasis, and diaphoresis may also be present. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9636_Imipramine-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9636_Imipramine-Tablets.html © The Swiss Pharmacy

20. Antidep Tablets (Generic Imipramine Hydrochloride Tablets) Treatment of Antidep Tablets Overdosage ECG should be obtained and cardiac monitoring should be immediately initiated. Protect the patient’s airway, establish an intravenous line and initiate gastric decontamination. A minimum of 6 hours of observation with cardiac monitoring and observation for signs of CNS or respiratory depression, hypotension, cardiac dysrhythmias and/or conduction blocks, and seizures is necessary. If signs of toxicity occur at anytime during this period, extended monitoring is required. All patients suspected of tricyclic overdose should receive gastrointestinal decontamination. This should include large volume gastric lavage followed by activated charcoal. If consciousness is impaired, the airway should be secured prior to lavage. Emesis is contraindicated. In patients with CNS depression, early intubation is advised because of the potential for abrupt deterioration. Seizures should be controlled with benzodiazepines, or if these are ineffective, other anticonvulsants (e.g., phenobarbital, phenytoin). URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9636_Imipramine-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9636_Imipramine-Tablets.html © The Swiss Pharmacy

21. Antidep Tablets (Generic Imipramine Hydrochloride Tablets) Antidep Tablets During Pregnancy Imipramine Hydrochloride (Antidep tablets) has been classified by the US FDA as Pregnancy Category C. Experience with Imipramine in pregnancy is limited. Since there have been isolated reports of a possible connection between the use of Imipramine and adverse effects on the fetus, treatment with Imipramine should be avoided during pregnancy, and only considered if the benefits expected justify the potential risk for the fetus. Epidemiological studies have suggested an increased risk of congenital abnormalities associated with use of antidepressants in pregnancy and the use of antidepressants in pregnancy may be associated with an increase in pre-term delivery. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9636_Imipramine-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9636_Imipramine-Tablets.html © The Swiss Pharmacy

22. Antidep Tablets (Generic Imipramine Hydrochloride Tablets) Antidep Tablets During Pregnancy Babies whose mothers had taken Imipramine Hydrochloride (Antidep tablets) up until delivery showed symptoms, such as dyspnoea, lethargy, colic, irritability, hypotension or hypertension, tremor or spasms, during the first month of life. To avoid such symptoms, Imipramine (Antidep tablets) should, if possible, be gradually withdrawn at least 7 weeks before the calculated date of confinement. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9636_Imipramine-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9636_Imipramine-Tablets.html © The Swiss Pharmacy

23. Antidep Tablets (Generic Imipramine Hydrochloride Tablets) Antidep Tablets Antidep Tablets (Generic Imipramine Hydrochloride Tablets) are manufactured by Torrent Pharmaceuticals Limited, India. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9636_Imipramine-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9636_Imipramine-Tablets.html © The Swiss Pharmacy