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XX males, no H-Y

XX males, no H-Y. Simpson et al., 1997. Harley, V. R. et al. Endocr Rev 2003;24:466-487. Human Y chromosome. (Bachtrog et al., 2001). (Neas & Shiao). Primary (gonadal) sex determination. testis. Bipotential gonad. ovary. Sox9 Gata4 Fog2 Sf1. Sry. testis. Wt1 Dax1 Fgf9 Dhh Ptgds.

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XX males, no H-Y

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  1. XX males, no H-Y Simpson et al., 1997

  2. Harley, V. R. et al. Endocr Rev 2003;24:466-487

  3. Human Y chromosome (Bachtrog et al., 2001)

  4. (Neas & Shiao)

  5. Primary (gonadal) sex determination testis Bipotential gonad ovary

  6. Sox9 Gata4 Fog2 Sf1 Sry testis Wt1 Dax1 Fgf9 Dhh Ptgds AMH Bipotential gonad Sf1 Wt1 Emx2 Cbx2 Gata4 Fog2 Lhx9 Lim1 ovary Wnt4 Fst

  7. AMH regulation WT1

  8. Yao, H. H.-C. et al. Biol Reprod 2006;74:978-983 Biology of Reproduction

  9. cell proliferation cell migration vascularization entry in mitotic arrest Sry testis entry in meiosis ovary

  10. Testis Ovary proliferation migration organization vascularization steroidogenesis (Brennan and Capel, 2004)

  11. XX XY E13 gonads Albrecht & Eicher, 2001

  12. Testis Coelomic bloodvessel

  13. PGC differentiation mesonephros RA gonad CYP26B1 no meiotic entry PGCs XX XY mesonephros mesonephros RA RA gonad gonad CYP26B1 no CYP26B1 no meiotic entry PGCs meiotic entry PGCs

  14. Ovotestis

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