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Molecular Targets Development Program, CCR, NCI

Molecular Targets Development Program, CCR, NCI. Translational Research at the CCR. Genetics & Genomics. Integrated Systems Biology. Molecular Targets & Molecular Oncology. CCR Clinical Program. HIV/AIDS. Immunology, Immunotherapy & Immunoprophylaxis. Intramural/Extramural.

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Molecular Targets Development Program, CCR, NCI

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  1. Molecular Targets Development Program, CCR, NCI

  2. Translational Research at the CCR Genetics & Genomics Integrated Systems Biology Molecular Targets & Molecular Oncology CCR Clinical Program HIV/AIDS Immunology, Immunotherapy & Immunoprophylaxis Intramural/Extramural Imaging & Biomarkers Advanced Biomedical Technologies

  3. Center for Cancer Research • 15 clinical branches • 38 basic sciences laboratories • > 330 principal investigators

  4. MTDP Mission SNB19 A549 MTDP Lab Bench Data HTS Data

  5. MTDP Mission • Collaborate with CCR investigators to develop and apply molecular target-specific assays • Screen the NCI natural products repository and other sources of chemical diversity • Identify and characterize target-specific compounds • Provide active compounds to collaborating labs for use as bioprobes MTDP

  6. Target Consortium PIs Staff Scientists Molecular Target/Pathway Lab Chiefs Postdoctoral Fellows Proposal

  7. Initial Feasibility • Quality control of reagents and cell lines • Reagent stability • Reagent specificity and binding characteristics • Cellular growth characteristics • Time frame of assay • Stable end point • Signal to noise ratio • Availability of appropriate controls • Availability of required equipment • Availability of sufficient reagents

  8. Priority Areas • Screening Platforms • Natural Products • Protein Chemistry and Molecular Biology • Libraries • Imaging • Information Technology

  9. Screening Platforms Enzymatic - FRET Protein-Protein Interactions - Time-Resolved Fluorrescence - Electrochemiluminescence Cell-based - Colorimetric - Fluorometric - Luminescent Cell-Imaging - GFP Translocation - GFP Expression

  10. MTDP Ongoing Projects

  11. Current Libraries for Screening

  12. NCI’s Natural Products Collections and Extract Repository Collections Terrestrial Plants -Tropical and Subtropical Marine Invertebrates and Algae -Indopacific -Caribbean Selected Microbial Isolates -Cyanobacteria -Fungi > 65,000 Organisms > 170,000 Individual Extracts -Organic Solvent Extracts -Aqueous Extracts Extract Repository

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