Supplements For Your Nervous System
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Cancer Wellness Center May 13, 2010 Anne Leavell, MS, RD, LDN, CDE Department of Neurology, Northwestern Medical Faculty Foundation PowerPoint PPT Presentation


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Supplements For Your Nervous System. Cancer Wellness Center May 13, 2010 Anne Leavell, MS, RD, LDN, CDE Department of Neurology, Northwestern Medical Faculty Foundation. Supplements. Disclaimer:

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Cancer Wellness Center May 13, 2010 Anne Leavell, MS, RD, LDN, CDE Department of Neurology, Northwestern Medical Faculty Foundation

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Cancer wellness center may 13 2010 anne leavell ms rd ldn cde department of neurology northwestern medical facu

Supplements For Your Nervous System

Cancer Wellness Center

May 13, 2010

Anne Leavell, MS, RD, LDN, CDE

Department of Neurology, Northwestern Medical Faculty Foundation


Supplements

Supplements

Disclaimer:

Dietary supplementation should NOT be initiated without the supervision of a qualified physician. Check with your doctor before you begin.

Several of these supplements may have adverse effects


Supplements1

Supplements

  • Vitamin E

    • Powerful antioxidant that reduces levels of free radicals and oxidative stress.

    • Protects against side effects: numbness, tingling, burning and pain

  • B Complex: B1(thiamine), B2(riboflavin), B3(niacin), B5(pantothenic acid), B6(pyridoxine), B7(biotin), B9(folic acid), B12(cobalamins)

    • B12 deficiency results in damage to protective covering of nerves

    • Decrease in pain (B1/B6/B12)

    • Folic acid (B9): maintenance of nerve cells


Supplements2

Supplements

  • Acetyl-L-Carnitine

    • Neuroprotective properties

    • 2 small studies - limit chemotherapy induced neuropathy

    • More studies needed, effectiveness not established

  • Alpha lipoic acid

    • Benefit in diabetic neuropathy (less pain, burning and numbness)

    • Further studies needed for safety/efficacy of ALA in prevention/treatment of chemotherapy induced neuropathy


Supplements3

Supplements

  • Glutamine

    • A neutral nonessential amino acid though to have neuroprotective effects (particularly with Paclitaxel)

    • More research needed to assess efficacy of glutamine

  • Glutathione

    • Tripeptide thought to prevent neurotoxicity

    • Efficacy seen in 50 advanced gastric cancer undergoing cisplatin-based chemotherapy


Supplements4

Supplements

  • Magnesium/Calcium

    • Improvements in neurotoxicity following infusion

    • Caution: may cause diarrhea in large doses

    • Need more research to evaluate use as prevention/treatment of chemotherapy induced neuropathy

  • N-acetylcysteine (amino acid)

    • Powerful antioxidant

    • Animal studies have shown inhibition of diabetic neuropathy and protection against neuropathies caused by chemotherapy drugs


Supplements5

Supplements

  • Omega-3 fatty acids:

    • High quantities in coldwater fish (salmon) and widely consumed for anti-inflammatory powers

    • Essential fatty acids and important component of cell membranes, myelin sheath that protects nerves

    • Studies show ability to reduce demyelination of nerves and neuropathic pain


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