Smoking And Infertility. BY Mohammad A. Emam Prof. of Obstetrics and Gynecology Mansoura Faculty of Medicine Mansoura integrated fertility center (MIFC) – EGYPT. Introduction &Rationale. Smoking as a major health problem.
Smoking And Infertility
Mohammad A. Emam
Prof. of Obstetrics and Gynecology
Mansoura Faculty of Medicine
Mansoura integrated fertility center (MIFC) – EGYPT
Most women are aware that smoking causes:
More Than 40 Published Studies In Medical Literature
(active and passive ):
> 4.000 chemical compounds,
43 carcinogens or poisons
> 300 polycyclic aromatic hydrocarbons.
methyl isocyanate(lethal poison).
bezene,( a potent toxicant)
Nicotine and its metabolites, cotinine
Polonium 210(a carcinogenic radioactive elem),
CadmiumSubstances In Smoke
( Middle East Fertility Society 10 th a\Annual Scientific Meeting Lebanon ,December 10-13,2003) o-76
Characteristics Assisted Fertilization?
Number of cases
Number of cycles
Mature follicles / Cycle
Oocytes retrived / cycle
Oocytes Metaphase II/ cycle
Oocytes fertilized/ cycle
/ Embryos grade Acycle
Clinical pregnancy rate (%)
<0.001Table-2: The Outcome of ICSI in Passive Smokers & Non Smokers
The Egyptian Journal Of Dermatology and Venereology vol 22 ,N 2&3 2002
It is not known how long the damaging effects of smoking last after quitting butOne important investigation showed that cessation of smoking for at least two months before attempting IVF significantly improved chances for conception.
1.The phasing out and banning of smoking in home should be an integral part of human infertility treatment.
2.Further studies to show the correlation between the duration of exposure to cigarette smoke and the fertilization rate, are needed.
3.Further studies on the levels of reactive oxygen species (ROS) in the follicular fluid in passive smokers are needed.