Multiple Sclerosis. Walter Royal, III, MD Associate Professor, Department of Neurology University of Maryland School of Medicine Director, Maryland Center for Multiple Sclerosis Treatment and Research. What is Multiple Sclerosis?.
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Walter Royal, III, MD
Associate Professor, Department of Neurology
University of Maryland School of Medicine
Director, Maryland Center for Multiple Sclerosis Treatment and Research
Optic nervesThe Human Nervous System
BBB=blood-brain barrier; APC=antigen-presenting cell.
Adapted from Miller et al. Continuum: Multiple Sclerosis (Part A). 1999;5:7.
Dizygotic (non-identical) twins
Child of parent with MS
Sibling of person with MS
25 – 30%
3 – 4.5%
Up to 19% of patients have an affected relative
Multiple Sclerosis Clinical Subtypes
Lublin FD et al. Neurology. 1996;46:907-911.
MS Lesions Over time
Time lapse = 1 year
Images acquired over the course of 7 years from a single person with untreated MSBrain Atrophy (Shrinkage) in Untreated MS