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Ernest T. Andalcio Executive Director, Site Head Informatics Pfizer Global Research & Development April 10, 2003

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Internet2 & Pharma Industry National Priorities for Transforming Healthcare Quality Report - implications for patient safety and internet applications. Ernest T. Andalcio Executive Director, Site Head Informatics Pfizer Global Research & Development April 10, 2003. Intro.

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Internet2 & Pharma IndustryNational Priorities for Transforming Healthcare Quality Report - implications for patient safety and internet applications

Ernest T. Andalcio

Executive Director, Site Head Informatics

Pfizer Global Research & Development

April 10, 2003

intro
Intro
  • Ernest Andalcio - Executive Director - Ann Arbor Labs
  • With Pfizer for 5 years
    • before that Bristol-Myers Squibb, Johnson & Johnson and Procter & Gamble
  • Responsible for mobilizing the talents of IT staff to identify, design, develop and implement robust technology solutions enabling delivery of scientific excellence, and for promoting best practices, fostering IT knowledge-sharing and exploring innovative new technologies
intro3
Intro
  • Challenges for Pharma Industry
  • Opportunities
  • Share some Learnings
topics contents
Topics/Contents
  • Pharmaceutical Industry
    • Challenges
    • Opportunities
    • Learnings
pfizer research development
Pfizer Research & Development
  • Largest privately funded biomedicalresearch organization
    • Seven major research sites
    • 2002 R & D investment of $5.3 billion
  • Count on a few new medicines to reachthe market each year
    • 4 filings planned for 2003
    • Target of 20 filings in next 5 years
  • Mission…”We will be the most consistently productive R&D organization in the industry.”
topics contents6
Topics/Contents
  • Pharmaceutical Industry
    • Challenges
    • Opportunities
    • Learnings
challenges in our industry
Challenges in our Industry
  • Balancing
    • Patient needs
    • Medicine
    • Patents
    • New Regulations
    • Profitability
    • Risk
    • Social responsibility
    • Shareholder expectations
clinical trials require more patients
Clinical Trials Require More Patients

Worldwide Industry Number of Patients per NCE

Source: Parexel Pharmaceutical R&D Statistical Sourcebook 2001; Centerwatch, An Industry in Evolution 2001

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Challenges - the long road to a new medicine & how Internet2solutions could one-day help the process

Registration

Full

Development

Exploratory Development

Discovery

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Complex Disease Targets

Poor Absorption

  • Not Sufficiently Selective

Too Long in Body

  • Competition

Adverse Reactions

Side Effects

Unsafe

  • Low Levels in Body

Unstable

Not Effective Enough

Impractical To Make

Challenges -R&D Attrition (why new chemical entities fail)

Most

Compounds

Do Not Become

Medicines

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Pharmaceutical Technology in Action

Gather, analyze and present valuable and timely information to therapeutic project teams for high-priority targets.

Use information to help identify novel, high quality targets that may be pursued by the therapeutic project teams.

  • Data Mining
  • Sequence Analysis
  • Information Storage/Retrieval (Database)
  • Information Presentation
the challenge
The Challenge…
  • Biology: The Target
  • Select the disease-related protein
  • Understand its function and role
  • Chemistry: The Compound
  • Optimize the potency
  • Avoid adverse pharmacokinetics
  • Avoid adverse toxic effects
topics contents13
Topics/Contents
  • Pharmaceutical Industry
    • Challenges
    • Opportunities
    • Learnings
opportunities the future of medicine
Opportunities - The Future of Medicine
  • Freedom from heart disease
  • A full, normal life for diabetics
  • Preserving the antibiotic miracle
  • Taking the fear out of cancer
  • Eliminating frailty in the elderly
  • Preventing Alzheimer’s disease
opportunities the future of medicine15
Opportunities - The Future of Medicine
  • Central Nervous System
  • Diabetes
  • Women’s Health
  • Cardiovascular Disease
  • HIV/AIDs
  • Urogenital
  • Pulmonary

20 new filings in next 5 years

opportunities pharma informatics
Opportunities - Pharma Informatics
  • Increase productivity
    • Seek different ways of working to increase the number of medicines that make it to full development annually
    • Enable new business processes: Improve data/information for timely decision-making
  • Leverage Scale
    • Take advantage of Global Capacity
    • Maximize use of Best Practices: Quality and Architecture of systems used
topics contents17
Topics/Contents
  • Pharmaceutical Industry
    • Challenges
    • Opportunities
    • Learnings
learnings opportunities for internet2 to make it happen
Learnings - Opportunities for Internet2 to make it happen
  • Due to the nature of our business - research - enabling technologies like Internet2 aid internal global execution of the R&D process
    • E.g. “Flipping through” large, secure files (e.g. x-ray images) to spot changes in size of tumors
  • Pfizer does global R&D, however, due to the nature of our business – highly proprietary – it is a largely secure intranet environment:
    • though we accept information from outside vendors using “safe zones” technologies
learnings opportunities for internet2 to make it happen19
Learnings - Opportunities for Internet2 to make it happen
  • Enabling new business processes
    • Streamlined Discovery & Development processes
    • Improved data/information for more timely (real-time) decision-making (Hi bandwidth human interactions! “Charles Yun”)
      • First-time
      • Better
      • Earlier
  • Enabling Digital Science“David G. Messerschmidt”
summary
Summary
  • Pharma Industry (Challenges/Opportunities)
  • Pharmaceutical R&D processes
  • Internet2… can enable real-time analysis, dialogue and … “discovery” of new medicines
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