The intact blood vessels undergo constriction to control blood loss, while the broken ones need to be repaired or completely replaced with new ones. Angiogenesis or the process of formation of new blood vessels involves the synthesis of many complex chemicals and marks the beginning of the Remodelling phase. Read More at http://www.scientificanimations.com/wounds-healing-process-angiogenesis/
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Under normal conditions, wound healing is a dynamic process involving four phases - Coagulation, Inflammation, Tissue Formation and Tissue Remodeling, that overlap in time.
A large number of cellular factors regulate these processes. Among them, Vascular endothelial growth factor (VEGF) has been identified as one of the most potent and predominant, potentially playing a pivotal role in each phase of wound healing, particularly in the promotion of angiogenesis.
Angiogenesis is the process by which new blood vessels grow and is a critical component of Wound Healing providingnutrients to newly formed tissues.
Most types of injuries damage blood vessels. The resulting coagulation is a rapid fire response to initiate hemostasis and protect against excessive blood loss.
With the aggregation and degranulation of platelets within the forming fibrin clot, a number of mediators and cytokines are released including vascular endothelial growth factor (VEGF) that initiate the tissue repair process.
VEGF has multiple functions. It acts as a vascular permeability factor influencing the extubation of plasma proteins to create a temporary support structure into which leukocytes, fibroblasts, endothelial cells and epithelial cells subsequently migrate.
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