The World of West Coast Biotech: Needs and Opportunities. Franz F. Hefti July 2005. How Many Jobs?. Biotech Employees in California: 225,000 Source: State of California, 2004 Employment Development Department. How Many Pharmacologists?. ¼ PhD Pharmacologists
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The World of West Coast Biotech:
Needs and Opportunities
Franz F. Hefti
Biotech Employees in California: 225,000
Source: State of California, 2004
Employment Development Department
¼ PhD Pharmacologists
~ 4000 positions in California
Easy to recruit
Difficult to recruit
Studies ofDisease Mechanisms
efficacy in animal models
Class of receptors/channels/transporters
Can we link it to a disease?
Disease-mechanism based Neuropharmacology: Example Alzheimer
What do we know about the disease mechanism?
What are the current drugs?
How do we find new targets?
How are the drug candidates further developed?
David L. Sloane, Ph.D.
since 2004 Associate Director,
2000 -2003 Sr. Scientist,
1995- 2000 Scientist III
1993- 1995 Scientist II
Mark Varney, Ph.D.
VP Pharmacology, Sepracor Inc.
IND: anti-NGF for pain
Foundation by A. Rosenthal
Focus on cancer therapeutics
Formation Neurosci. Res. Dept.
Rinat-Genentech partnership agreement on anti-NGF
Clinical studies with NGF in neuropathy
Start of neuroscience research
Quality Control/Quality Assurance
Expert technical skills
Understanding of drug discovery and development
Motivation and intellectual flexibility
Understanding of industry
Ability to change and adjust
Willingness to move away from the bench