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THE FLY THAT WOULD BE KING

THE FLY THAT WOULD BE KING. Glossina. African Sleeping Sickness. 300-500,000. African trypanosomiasis Trypomastigote morphology. Salivarian trypanosome groups. Trypanosoma vivax – Old and New World of large mammals – Mechanical transmission using many vectors

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THE FLY THAT WOULD BE KING

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  1. THE FLY THAT WOULD BE KING Glossina

  2. African Sleeping Sickness 300-500,000

  3. African trypanosomiasisTrypomastigote morphology

  4. Salivarian trypanosome groups Trypanosoma vivax – Old and New World of large mammals – Mechanical transmission using many vectors Trypanosoma congolense – Old World of large mammals– Mouthpart development in Glossina Trypanosoma brucei/evansi – brucei group includes: T. brucei brucei –nagana in cattle T. brucei gambiense – chronic or West African sleeping sickness T. brucei rhodesiense – acute or East African sleeping sickness All have full development in Glossina evansi group includes: T. evansi – mechanical transmission in many vectors including vampire bats T. equinum – mechanically transmitted by horse flies T. equiperdum – sexually transmitted

  5. Trypanosoma Life Cycle

  6. Trypanosome Antigenic Variation

  7. Tsetse Fly and Human Disease Distribution

  8. Tsetse Fly and Cattle Distribution

  9. African Ecology and Vector Distribution Glossina palpalis group Glossina palpalis group Glossina morsitans group

  10. Glossina – Life Cycle 8 – 9 days 6(male) – 14(female) weeks 4 – 5 weeks

  11. Glossina - Life Cycle (cont.)

  12. Natural Reservoir Hosts Thompson’s gazelle Impala Oryx Warthog

  13. Domesticated Reservoir Hosts N’dama Zebu Warthogs

  14. Trypanotolerant Cattle Populations

  15. Trypanosomiasis Risk - Humans

  16. Human Population Density - Africa

  17. Tsetse surveilance

  18. Tsetse Control

  19. African trypanosomiasisDiagnosis

  20. African trypanosomiasisTreatment Suramin - Pentamidine (early) Melarsoprol (late) DFMO Aventis Pharm & WHO

  21. Africa Deforestation

  22. Africa Grassland burning Tanzania Zambezi River

  23. Displaced Populations

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