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Influenza Vaccine Responses. Zhiping Ye, M.D., Ph.D. Division of Viral Products. Prepared for Vaccines and Related Biological Products Advisory Committee 21 February 2008. Serum panels used for serology. AUSTRALIA, IAN BARR, PH.D. ADULTS A/NEW CALEDONIA/20/99 IVR-116 (H1N1)

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influenza vaccine responses

Influenza Vaccine Responses

Zhiping Ye, M.D., Ph.D.

Division of Viral Products

Prepared for

Vaccines and Related Biological

Products Advisory Committee

21 February 2008

slide2

Serum panels used for serology

AUSTRALIA, IAN BARR, PH.D. ADULTS A/NEW CALEDONIA/20/99 IVR-116 (H1N1)

WHO, AUSTRALIA ELDERLY A/WISCONSIN/67/2005 X161B (H3N2)

B/MALAYSIA/2506/2005

EUROPE, JOHN WOOD, PH.D. ADULTS A/SOLOMON ISLANDS/03/2006 IVR-145 (H1N1)

NIBSC, ENGLAND ELDERLY A/WISCONSIN/67/2005 X161B (H3N2)

B/MALAYSIA/2506/2005

JAPAN, TAKATO ODAGARI, PH.D. ADULTS A/SOLOMON ISLANDS/03/2006 IVR-145 (H1N1)

NIID, JAPAN ELDERLY A/HIROSHIMA/52/2006 IVR-142 (H3N2)

B/MALAYSIA/2506/2005

USA, STEFAN GRAVENSTEIN, M.D. ADULTS A/SOLOMON ISLANDS/03/2006 IVR-145 (H1N1)

EASTERN VIRGINIA ELDERLY A/WISCONSIN/67/2005 X161B (H3N2)

MEDICAL SCHOOL PAEDIATRIC B/MALAYSIA/2506/2005

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antigens for serology h1n1
Antigens for serology (H1N1)

VACCINE STRAIN

A/Solomon Islands/03/2006 IVR-145

REPRESENTATIVE CURRENT STRAINS

  • A/Brisbane/59/2007
  • A/Egypt/10/2007
  • A/Hiroshima/93/2007
  • A/Netherlands/345/2007
  • A/Norway/1747/2007
  • A/Paris/0641/2007
  • A/South Dakota/6/2007
  • A/Cambodia/0371/2007
  • A/Brisbane/3/2006

2

antigens for serology h3n2
Antigens for serology (H3N2)

VACCINE STRAINS

A/Wisconsin/67/2005 X161B

A/Hiroshima/52/2006 IVR-142

REPRESENTATIVE CURRENT STRAINS

  • A/Brisbane/10/2007
  • A/Henan Jinshui/147/2007
  • A/Taiwan/760/2007
  • A/Texas/37/2007
  • A/Toyama/119/2007
  • A/Uruguay/716/2007

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antigens for serology b
Antigens for serology (B)

VACCINE STRAIN

B/Malaysia/2506/2004 (Vic)

REPRESENTATIVE CURRENT STRAINS

  • B/Hiroshima/320/2007 (Vic)
  • B/Pennsylvania/5/2007 (Vic)
  • B/Bangladesh/3333/2007
  • B/Delaware/1/2007
  • B/Florida/4/2007
  • B/Norway/1760/2007
  • B/Sendai-H/114/2007

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serologic conclusions
Serologic conclusions

Studies with human sera collected after immunization with current vaccines show that:

  • H1N1
    • Representative recent viruses were less well inhibited by HA antibodies

to current vaccine strains (A/Solomon Islands/3/2006-like virus).

  • H3N2
    • Representative recent viruses were less well inhibited by HA antibodies

to current vaccine strain (A/Wisconsin/67/2005-like virus).

  • B
    • B/VICTORIA/2/87-lineage
      • Representative recent viruses were well inhibited by HA antibodies

to current vaccine strain (B/Malaysia/2506/2004-like virus).

    • B/YAMAGATA/16/88-lineage
      • Representative recent viruses generally were less well inhibited by

HA antibodies to the current vaccine strain.

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