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Influenza Vaccine Responses. Zhiping Ye, M.D., Ph.D. Division of Viral Products. Prepared for Vaccines and Related Biological Products Advisory Committee 21 February 2008. Serum panels used for serology. AUSTRALIA, IAN BARR, PH.D. ADULTS A/NEW CALEDONIA/20/99 IVR-116 (H1N1)

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Influenza Vaccine Responses

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Influenza vaccine responses l.jpg

Influenza Vaccine Responses

Zhiping Ye, M.D., Ph.D.

Division of Viral Products

Prepared for

Vaccines and Related Biological

Products Advisory Committee

21 February 2008


Slide2 l.jpg

Serum panels used for serology

AUSTRALIA, IAN BARR, PH.D. ADULTS A/NEW CALEDONIA/20/99 IVR-116 (H1N1)

WHO, AUSTRALIA ELDERLY A/WISCONSIN/67/2005 X161B (H3N2)

B/MALAYSIA/2506/2005

EUROPE, JOHN WOOD, PH.D. ADULTS A/SOLOMON ISLANDS/03/2006 IVR-145 (H1N1)

NIBSC, ENGLAND ELDERLY A/WISCONSIN/67/2005 X161B (H3N2)

B/MALAYSIA/2506/2005

JAPAN, TAKATO ODAGARI, PH.D. ADULTS A/SOLOMON ISLANDS/03/2006 IVR-145 (H1N1)

NIID, JAPAN ELDERLY A/HIROSHIMA/52/2006 IVR-142 (H3N2)

B/MALAYSIA/2506/2005

USA, STEFAN GRAVENSTEIN, M.D. ADULTS A/SOLOMON ISLANDS/03/2006 IVR-145 (H1N1)

EASTERN VIRGINIA ELDERLY A/WISCONSIN/67/2005 X161B (H3N2)

MEDICAL SCHOOLPAEDIATRIC B/MALAYSIA/2506/2005

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Antigens for serology h1n1 l.jpg

Antigens for serology (H1N1)

VACCINE STRAIN

A/Solomon Islands/03/2006 IVR-145

REPRESENTATIVE CURRENT STRAINS

  • A/Brisbane/59/2007

  • A/Egypt/10/2007

  • A/Hiroshima/93/2007

  • A/Netherlands/345/2007

  • A/Norway/1747/2007

  • A/Paris/0641/2007

  • A/South Dakota/6/2007

  • A/Cambodia/0371/2007

  • A/Brisbane/3/2006

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Hi antibody responses to the h1n1 adult population cber l.jpg

HI ANTIBODY RESPONSES TO THE H1N1 ADULT POPULATION (CBER)

3


Hi antibody responses to the h1n1 elderly population cber l.jpg

HI ANTIBODY RESPONSES TO THE H1N1 ELDERLY POPULATION (CBER)

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HI ANTIBODY RESPONSES TO THE H1N1 PEDIATRIC POPULATION (CDC-CBER)

5


A solomon islands 3 2006 vaccine summary table viruses with 50 gmt reduction adult l.jpg

A/Solomon Islands/3/2006 vaccineSUMMARY TABLEVIRUSES WITH> 50% GMT REDUCTION(ADULT)

6


A solomon islands 3 2006 vaccine summary table viruses with 50 gmt reduction elderly l.jpg

A/Solomon Islands/3/2006 vaccineSUMMARY TABLEVIRUSES WITH> 50% GMT REDUCTION(ELDERLY)

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Antigens for serology h3n2 l.jpg

Antigens for serology (H3N2)

VACCINE STRAINS

A/Wisconsin/67/2005 X161B

A/Hiroshima/52/2006 IVR-142

REPRESENTATIVE CURRENT STRAINS

  • A/Brisbane/10/2007

  • A/Henan Jinshui/147/2007

  • A/Taiwan/760/2007

  • A/Texas/37/2007

  • A/Toyama/119/2007

  • A/Uruguay/716/2007

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Hi antibody responses to the h3n2 adult population uk l.jpg

HI ANTIBODY RESPONSES TO THE H3N2ADULT POPULATION (UK)

9


Hi antibody responses to the h3n2 elderly population uk l.jpg

HI ANTIBODY RESPONSES TO THE H3N2ELDERLY POPULATION (UK)

10


Hi antibody responses to the h3n2 pediatric population cdc cber l.jpg

HI ANTIBODY RESPONSES TO THE H3N2 PEDIATRIC POPULATION (CDC-CBER)

11


A wisconsin 67 2005 like vaccines summary table viruses with 50 gmt reduction adult l.jpg

A/Wisconsin/67/2005-like VACCINESSUMMARY TABLEVIRUSES WITH> 50% GMT REDUCTION(ADULT)

12


A wisconsin 67 2005 like vaccines summary table viruses with 50 gmt reduction elderly l.jpg

A/Wisconsin/67/2005-like VACCINESSUMMARY TABLEVIRUSES WITH> 50% GMT REDUCTION(ELDERLY)

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Antigens for serology b l.jpg

Antigens for serology (B)

VACCINE STRAIN

B/Malaysia/2506/2004 (Vic)

REPRESENTATIVE CURRENT STRAINS

  • B/Hiroshima/320/2007 (Vic)

  • B/Pennsylvania/5/2007 (Vic)

  • B/Bangladesh/3333/2007

  • B/Delaware/1/2007

  • B/Florida/4/2007

  • B/Norway/1760/2007

  • B/Sendai-H/114/2007

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HI ANTIBODY RESPONSES TO BADULT POPULATION (CDC)

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Hi antibody responses to b elderly population cdc l.jpg

HI ANTIBODY RESPONSES TO BELDERLY POPULATION (CDC)

16


Hi antibody responses to b pediatric population cdc cber l.jpg

HI ANTIBODY RESPONSES TO B PEDIATRIC POPULATION (CDC-CBER)

17


B malaysia 2560 2004 vaccines summary table viruses with 50 gmt reduction adult l.jpg

B/Malaysia/2560/2004 VACCINESSUMMARY TABLEVIRUSES WITH> 50% GMT REDUCTION(ADULT)

18


B malaysia 2560 2004 vaccines summary table viruses with 50 gmt reduction elderly l.jpg

B/Malaysia/2560/2004 VACCINESSUMMARY TABLEVIRUSES WITH> 50% GMT REDUCTION(ELDERLY)

19


Serologic conclusions l.jpg

Serologic conclusions

Studies with human sera collected after immunization with current vaccines show that:

  • H1N1

    • Representative recent viruses were less well inhibited by HA antibodies

      to current vaccine strains (A/Solomon Islands/3/2006-like virus).

  • H3N2

    • Representative recent viruses were less well inhibited by HA antibodies

      to current vaccine strain (A/Wisconsin/67/2005-like virus).

  • B

    • B/VICTORIA/2/87-lineage

      • Representative recent viruses were well inhibited by HA antibodies

        to current vaccine strain (B/Malaysia/2506/2004-like virus).

    • B/YAMAGATA/16/88-lineage

      • Representative recent viruses generally were less well inhibited by

        HA antibodies to the current vaccine strain.

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