the body s defenses
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The body’s defenses. Lines of defense Lymphatic system Inflammation Features of immune system Memory B-cells Primary and secondary immune responses Antibody Antigen Agglutination macrophage. lymphocyte Phagocytosis Complement system Humoral immunity Cell-mediated immunity B cell

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Presentation Transcript
reading ch 43 keywords
Lines of defense

Lymphatic system

Inflammation

Features of immune system

Memory B-cells

Primary and secondary immune responses

Antibody

Antigen

Agglutination

macrophage

lymphocyte

Phagocytosis

Complement system

Humoral immunity

Cell-mediated immunity

B cell

Helper T cell

Cytotoxic T cell

Reading: Ch. 43; Keywords
non specific
Non-specific
  • First line
    • Skin
    • Mucous membranes
    • Secretions of skin and mucous membranes
  • Second line
    • Phagocytic white blood cells
    • Anti-microbial proteins
    • Inflammatory response
focus on immune system 3rd line of defense
Focus on immune system(3rd line of defense)
  • Protects body against specific invaders
key features
Key features
  • Specificity
  • Diversity
  • Memory
  • Self/Nonself Recognition
two types of immune responses
Two types of immune responses
  • Humoral
  • Cell-mediated
key features14
Key features
  • Specificity
  • Diversity
  • Memory
  • Self/Nonself Recognition

Humoral immunity

memory cells function in secondary immune response
Memory cells function in secondary immune response
  • Primary immune response - first exposure
  • Secondary immune response - second exposure
summary
Summary
  • Lag in primary response due to proliferation from a single clone
  • Secondary (2°) response is from multiple memory cells
  • 2° response has less of a lag and is stronger
inactivate antigens30
Inactivate antigens
  • Neutralization
  • Agglutination
  • Precipitation
antibodies inactivate antigens
Antibodies inactivate antigens
  • Neutralization of invaders
  • Agglutination
  • Precipitation of soluble antigens
  • The above enhance phagocytosis
  • One final mechanism: Complement system
summary37
Summary
  • Complement proteins interact with antibodies to kill invading cells
  • Binding of antibody is followed by attachment of complement proteins
  • Protein complex becomes activated
  • Pore is formed in pathogen’s membrane
  • Goodbye pathogen
two types of immune responses38
Two types of immune responses
  • Humoral
  • Cell-mediated
cell mediated
Cell-mediated
  • Complicated, involves cellular components
  • Will briefly touch on role of helper T cells
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