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Databases. Sequence and Bibliographic Genomic Clinical and Mutation Homologies Integrated Most databases are accessible from a web page are interlinked. Types of Database. Main nucleic acid sequence databases EMBL GenBank DDBJ Main protein sequence databases Swiss Prot

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Presentation Transcript
types of database
Sequence and Bibliographic

Genomic

Clinical and Mutation

Homologies

Integrated

Most databases

are accessible from a web page

are interlinked

Types of Database
sequence databases
Main nucleic acid sequence databases

EMBL

GenBank

DDBJ

Main protein sequence databases

Swiss Prot

also TREMBL, GenPept

Often integrated with other databases

Sequence Databases
integrating sequence and bibliographic databases
Entrez

Links nucleic acid sequences, protein sequences and MEDLINE

Powerful and easy to use

SRS

Universal system for searching sequence and other databases

Available worldwide including at HGMP

Integrating Sequence and Bibliographic Databases
genomic databases
GDB

Repository for mapping and genomic data for the Human Genome Project

Powerful; links to other databases

ACeDB

Developed to provide access to C.elegans data

Genomic Databases
clinical and mutation databases
OMIM

Online Mendelian Inheritance in Man

Database of disease-linked genes and associated phenotypes

Links to Entrez, GDB and other databases

HGMD

Database of sequences and phenotypes of disease-causing mutations

Disease-specific mutation databases

Clinical and Mutation Databases
homology databases
MGI

Mapping and gene expression data for the mouse

Human homologies

Links to GDB and Entrez

Many other organism-specific databases

can be used to search for homologs of human genes

Homology Databases
an integrated database
GeneCards

Integrated resource of information on human genes and their products

Major emphasis on human disease

Links to many kinds of biomedical information

Sequence databases

OMIM, HGMD, MDB

Doctors’ Guide to the Internet

An Integrated Database
database s earching t ips
Look for links to Help or Examples

Try Boolean searches

Be careful with UK/US spelling differences

leukaemia vs leukemia

haemoglobin vs hemoglobin

colour vs color

Database Searching Tips
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