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ATP III Guidelines Benefit Beyond LDL-Lowering: The Metabolic Syndrome as a Secondary Target of Therapy

Metabolic Syndrome. SynonymsInsulin resistance syndrome(Metabolic) Syndrome XDysmetabolic syndromeMultiple metabolic syndrome. Metabolic Syndrome (continued). CausesAcquired causesOverweight and obesityPhysical inactivityHigh carbohydrate diets (>60% of energy intake) in some personsGenetic causes.

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ATP III Guidelines Benefit Beyond LDL-Lowering: The Metabolic Syndrome as a Secondary Target of Therapy

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    1. ATP III Guidelines Benefit Beyond LDL-Lowering: The Metabolic Syndrome as a Secondary Target of Therapy

    3. Metabolic Syndrome (continued) Causes Acquired causes Overweight and obesity Physical inactivity High carbohydrate diets (>60% of energy intake) in some persons Genetic causes

    4. Metabolic Syndrome (continued) Therapeutic Objectives To reduce underlying causes Overweight and obesity Physical inactivity To treat associated lipid and non-lipid risk factors Hypertension Prothrombotic state Atherogenic dyslipidemia (lipid triad)

    5. Metabolic Syndrome (continued) Management of Overweight and Obesity Overweight and obesity: lifestyle risk factors Direct targets of intervention Weight reduction Enhances LDL lowering Reduces metabolic syndrome risk factors Clinical guidelines: Obesity Education Initiative Techniques of weight reduction

    6. Metabolic Syndrome (continued) Management of Physical Inactivity Physical inactivity: lifestyle risk factor Direct target of intervention Increased physical activity Reduces metabolic syndrome risk factors Improves cardiovascular function Clinical guidelines: U.S. Surgeon General’s Report on Physical Activity

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