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Prostate Cancer Association Studies. David Moskowitz. A common variant associated with prostate cancer in European and African populations. Nature Genetics (2006). Allele -8 of microsatellite DG8S737 identified as associated with prostate cancer

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Prostate Cancer Association Studies

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Prostate cancer association studies l.jpg
Prostate CancerAssociation Studies

David Moskowitz


A common variant associated with prostate cancer in european and african populations l.jpg
A common variant associated with prostate cancer in European and African populations

Nature Genetics (2006)


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  • 600-kb region surrounding DG8S737 was genotyped with prostate cancer

  • 53 SNPs and 6 microsatellites identified in relevant LD block

  • 37 of these SNPs were found to be associated with prostate cancer, most significantly allele A of rs1447295


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Admixture mapping identifies 8q24 as a prostate cancer risk locus in African-American men

PNAS (2006)


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  • Admixture mapping used since African American population has recent ancestry of both African and European populations

  • 8q24 region identified as having a highly significant association with prostate cancer

  • However, alleles identified in previous study do not fully describe the results of the admixture scan


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Genome-wide association study of prostate cancer identifies a second risk locus at 8q24

Nature Genetics (2007)


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  • Genome-wide association study confirmed rs1447295 as a disease causing SNP relevant to prostate cancer

  • New locus at rs6983267 also identified, with an even higher PAR than rs1447295 (21% as opposed to 9%)

  • Overall, the causative allele (G) has a 50% frequency in Europeans


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  • No relationship between age and allelic risk was found disease causing SNP relevant to prostate cancer

  • No relationship between the MYC oncogene and the SNPs was found

  • Although the G allele of rs6983267 confers less risk than does the A allele of rs14417295, it is much more frequent (50% compared to 11%)


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Multiple prostate cancer risk variants on 8q24 the admixture mapping

Nature Genetics (2007)


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  • Region 1 has weak associations in African Americans the admixture mapping

  • Risk alleles in region 2 are present with much greater frequency in African American population, which helps to explain the admixture scan

  • Region 2 gives stronger results in younger men


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