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Mitosis to Meiosis. Sept. 6, 2005. Centriole Dynamics. Mitosis. What happens in G1, S, G2? What is controlling the transitions? Explain how any process in the cell requires hundreds or thousands of genes.

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Mitosis to meiosis

Mitosis to Meiosis

Sept. 6, 2005


Centriole

Dynamics


Mitosis
Mitosis

  • What happens in G1, S, G2?

  • What is controlling the transitions?

  • Explain how any process in the cellrequires hundreds or thousands of genes.

  • Give an example how timing of genes is as important as the products of the genes.

  • How does Metaphase “happen”?

  • How does Anaphase “happen”?


Cyclins and cell cycle
Cyclins and Cell Cycle

Cell Cycle Model


Cell Cycle Controls

  • Cyclins (accelerators)

  • Kinases (breaks)

  • Hormones (initiators, inhibitors)

  • DNA replication process

  • DNA repair processes (p53 protein)

  • Microtubule (Spindle) processes


Mitosis1

1995 Process

Description

1960 ProcessDescription

Mitosis



Mitosis

Cell Cycle

Interphase G2

Interphase G1

Synthesis for mitosis

House-keeping processes

Cell differentiation

House-keeping processes

Interphase S

Restriction

Point

100’s to 1,000’s of sites initiate DNA replication


Chromosome “painting” with fluorescent antibodies

specific for chromosome proteins characteristic

of each homologus pair

Polar view showing

homologues in

mitotic metaphase

Nucleus


Initiation of anaphase
Initiation ofAnaphase

(follows release

of M-arrest)


Meiosis two divisions
Meiosis: Two Divisions

  • How does Meiosis I differ from Mitosis?

  • What kinds of regulatory systems would achieve the conversion of Mitosis into Meiosis I?


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