Effect of Certain Agonists Antagonists on Isolated Guinea-pig Ileum
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Effect of Certain Agonists Antagonists on Isolated Guinea-pig Ileum

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Objectives . Discuss the types of receptor present in guinea-pig ileumExplain the action of agonists
Effect of Certain Agonists Antagonists on Isolated Guinea-p...

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1. Effect of Certain Agonists & Antagonists on Isolated Guinea-pig Ileum Lab #4

2. Objectives Discuss the types of receptor present in guinea-pig ileum Explain the action of agonists & their specific antagonists Discuss the reasons for using guinea-pig ileum Explain of effect of different drugs on isolated guinea-pig ileum curve

3. Types of receptors in GPI 1- Cholinergic receptors 2- Serotonergic or tryptaminergic receptors (5-HT1?5-HT7) 3- Histaminergic receptors

4. Cholinergic receptors 1- NN R Agonist: Dil. Nicotine Antagonist: Conc. Nicotine 2- M3 R Agonist: Ach Antagonist: Atropine

5. Serotonergic or tryptaminergic receptors Serotonin = 5-HT(5-hydroxytryptamine) 5-HT receptors in GPI: 5-HT2A Agonist: serotonin Antagonist: ketanserin methysergide cyproheptadine (blocks 5-HT2A & H1)

6. Histaminergic receptors

7. Direct acting drugs Direct spasmogen e.g. Barium chloride Direct spasmolytic e.g. Papaverine

8. Advantages of GPI No myogenic contraction More sensitive to histamine

9. Experiment

10. Experiment Identification of site of action of an unknown drug using isolated guinea-pig ileum


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