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Steroid Physiology. Basal Cortisol Production = 8-25 mg in 24hrsProduction can be increased 6-fold in stressDiurnal pattern of cortisol production lost in stress situationsCortisol T1/2 = 70-120 minutesBound to circulating CBG, albumin, ?1-acid glycoprotein10% free = biologically activeCBG decreases rapidly in critically ill pts ? increased free cortisol.

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