Chapter 3
Download
1 / 29

chapter 3 - PowerPoint PPT Presentation


  • 153 Views
  • Updated On :

Chapter 3. A. Gene function Genes and protein synthesis and mutation B. Genetic diseases Identification of genes Pedigrees/DNA markers Diseases (CF, PKU, Albinism, Huntington Disease, DMD) C. Use/Misuse of genetic information Genetic tests Prenatal testing

loader
I am the owner, or an agent authorized to act on behalf of the owner, of the copyrighted work described.
capcha
Download Presentation

PowerPoint Slideshow about 'chapter 3' - Olivia


An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -
Presentation Transcript
Slide1 l.jpg

Chapter 3

  • A. Gene function

    • Genes and protein synthesis and mutation

  • B. Genetic diseases

    • Identification of genes

    • Pedigrees/DNA markers

    • Diseases (CF, PKU, Albinism,

      • Huntington Disease, DMD)

  • C. Use/Misuse of genetic information

    • Genetic tests

    • Prenatal testing

    • PCR (polymnerase chain reaction)

    • Eugenics (positive/negative)


  • Slide2 l.jpg

    Chapter 4

    • Genetic engineering

      Restriction enzymes/plasmids

      Genetically engineered insulin

      Gene therapy

    • Use of Genetic information

    • Human Genome

      Genomics/Bioinformatics


    Slide3 l.jpg

    Chapter 4

    • Genetic engineering

      Restriction enzymes

      • Used to cut DNA at special sequences

      • e.g EcoR1 cuts at ---GAATTC---

      • ---CTTAAG---

      • palindrome -race car-


    Slide4 l.jpg

    Chapter 4

    • Genetic engineering

      Restriction enzymes

      • Used to cut DNA at special sequences

      • e.g EcoR1 cuts at ---GAATTC---

      • ---CTTAAG---

      • palindrome -race car-


    Slide5 l.jpg

    Chapter 4

    • Genetic engineering

      Restriction enzymes

      • Used to cut DNA at special sequences

      • e.g EcoR1 cuts at ---GAATTC---

      • ---CTTAAG---

      • palindrome -race car-


    Slide6 l.jpg

    Chapter 4

    • Genetic engineering

      Restriction enzymes

      • Used to cut DNA at special sequences

      • e.g EcoR1 cuts at ---GAATTC---

      • ---CTTAAG---

      • palindrome -race car-



    Slide8 l.jpg

    fig. 4-2

    Plasmid circular piece of non-chromosomal DNA




    Slide11 l.jpg

    Gene Therapy

    Put good gene into someone who doesn’t have it

    SCIDS

    bubble babies



    Slide13 l.jpg





    Slide17 l.jpg

    Chapter 4

    • Genetic engineering

      Restriction enzymes/plasmids

      Genetically engineered insulin

      Gene therapy

    • Use of Genetic information

    • Human Genome

      Genomics/Bioinformatics


    Slide18 l.jpg



    Slide20 l.jpg

    Genome

    complete genetic material of an organism

    Human Genome project:

    Proposed in 1986

    Funded in 1989

    Preliminary report in 2001 (94%)

    Completed in 2003


    Slide21 l.jpg

    Genome results

    • 95% of human DNA is non-coding (not genes)

    • Fewer genes found than expected (35,000)

    • Many genes have unknown

    • Only 1% of our genes are unique

      (similar to 46% of genes in yeast)

    • 200 genes like bacteria

    • mutation rates differ in different parts of genome

    • Many sites (15) for variability

      (each individual is genetically unique)

    23 =

    23 = 8

    223 = 8,388,608

    223 =

    2n


    Slide22 l.jpg

    study of the genome

    Genomics

    e.g., identify individual genes

    information generated is called bioinformatics

    uses molecular biology and computer science

    • 95% of human DNA is non-coding

    • introns (non-coding) and exons (coding)

      • see figs 4.9 and 4.10


    Slide23 l.jpg

    comparative and functional

    Genomics

    • similarities and relationships

    • simple vs. complex

    • gene families

    • gene functions

      • ……

    study the protein content of an organism

    Proteomics

    Normal function

    Disease processes

    Repair/drug interaction…..


    Slide24 l.jpg

    • Chapter 1

    • A. Properties of living things

      • list them and relate them to further materials

  • B. Scientific Method

    • subject matter and limitations

      • inductive vs. deductive reasoning

    • (specific to general) (general to specific; if…then)

    • Hypothesis: must be testable (falsifiable)

    • Experiments/observations test hypothesis

      • must be reproducible

      • must have appropriate controls


  • Slide25 l.jpg

    B. Scientific Method (cont)

    Ethics:

    deontological: written code, individual rights

    emphasis on actions

    (right vs wrong)

    utilitarian: greatest good for most

    emphasis onconsequences


    Genes chromosomes and dna l.jpg

    0

    Genes, Chromosomes and DNA

    Mendel and Peas

    simple inheritance patterns

    phenotype/genotype, dominant recessive

    heterozygous/homozygous, Mendels “laws”

    B. Chromosomal Basis of Inheritance

    Chromosomes

    Cell division: mitosis and meiosis

    Gene linkage, crossing over, nondisjunction

    Molecular basis of Inheritance

    DNA structure and replication


    Slide27 l.jpg

    Chapter 3

    • A. Gene function

      • Genes and protein synthesis and mutation

      • (diagram)

  • B. Genetic diseases

    • Identification of genes

    • Pedigrees/DNA markers

    • Diseases (PKU, Albinism, CF,

      • Huntington Disease, DMD)

  • C. Use/Misuse of genetic information

    • Genetic tests

    • Prenatal testing

    • PCR (polymnerase chain reaction)

    • Eugenics (positive/negative)


  • Slide28 l.jpg

    How proteins are made (protein synthesis):

    tRNA

    RNA Polymerase ribosomes (protein, rRNA)

    DNA mRNA protein

    4 "letters” 4 "letters” 20 "letters"

    transcriptiontranslation

    (in nucleus) (in cytoplasm)


    Slide29 l.jpg

    Chapter 4

    • Genetic engineering

      Restriction enzymes/plasmids

      Genetically engineered insulin

      Gene therapy

    • Use of Genetic information

    • Human Genome

      Genomics/Bioinformatics


    ad