Antifungal Agents. Lindsay Mayer, PharmD October 26, 2007. MOA: Binds to ergosterol within the fungal cell membrane resulting in depolarization of the membrane and the formation of pores. The pores permit leakage of intracellular contents. Exhibits concentration dependent killing.
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Lindsay Mayer, PharmD
October 26, 2007
Resistance occurs frequently and rapidly when flucytosine is given as monotherapy
Combination therapy is necessary
Toxicities occur more commonly in patients with renal impairment
UNC Hospital Formulary
Visual disturbance (30%)
Serious Adverse Events
Irreversibly inhibits B-1,3 –D glucan synthase, the enzyme complex that forms glucan polymers in the fungal cell wall. Glucan polymers are responsible for providing rigidity to the cell wall. Disruption of B-1,3-D glucan synthesis leads to reduced cell wall integrity, cell rupture, and cell death.
Gallagher JC, et al. Expert Rev Anti-Infect Ther 2004;2:253-268
Cappelletty et al. Pharmacotherapy 2007;27:369-88