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Lifecycle Nutrition. Developmental Nutrition FCSN 345. Dr. Virginia Bennett Office 134 PE Office hours: T & Th 1:00 e-mail: [email protected] Measures of a Successful Outcome of Pregnancy. Healthy Baby Healthy Mother Baby Survives the First Year of Life. Healthy Baby.

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Developmental nutrition fcsn 345 l.jpg
Developmental NutritionFCSN 345


Measures of a successful outcome of pregnancy l.jpg
Measures of a Successful Outcome of Pregnancy

  • Healthy Baby

  • Healthy Mother

  • Baby Survives the First Year of Life


Healthy baby l.jpg
Healthy Baby

  • Still Birth Ratio or Fetal Death Ratio

    • Early in Pregnancy: difficult to have reliable numbers of death rate

      • Why?

    • Later in Pregnancy: numbers are more reliable after 20 wks gestation

      • About 6.4 stillbirths per 1000 live births


Healthy mother maternal mortality l.jpg
Healthy Mother: Maternal Mortality

  • Static since 1982 at 7 to 8 mothers die per 100,000 births. About 1 death per day in the US

  • Big racial difference:

    • White 5.0

    • Black 20.8

    • Others 18.2

    • Why?



Infant mortality l.jpg
Infant Mortality

  • Infancy: First Year of Life

    • <28 days - neonatal

    • >28 days < 1 year - postneonatal

  • 2006: Infant Mortality Rate in US

    • 6.43 per 1000 live births

    • Ranked 42nd world-wide

    • 1950 29.2 but we were ranked 6th world-wide

    • Why?


Terminology l.jpg
terminology

  • Infant: first year of life

  • Neonatal: under 28 days of life

  • Early Neonatal: under 7 days of life

  • Post neonatal: 28 days – 11 months

  • Fetal mortality: fetal deaths over 20 weeks gestation

  • Late Fetal mortality: deaths over 28 weeks gestation


Cause of infant problems l.jpg
Cause of Infant Problems

  • Neonatal Problems: first 28 days after birth

    • What might be the reasons for problems here?

    • 4.7 in 2002

  • Post neonatal Problems: 28 days to one year

    • What might be the reasons for problems here?

    • 2.3 in 2002


In us l.jpg
In US

  • Most infant deaths happen in neonatal period

  • Perinatal mortality: adds fetal deaths plus early neonatal deaths


Better infant mortality rates l.jpg
Better Infant Mortality Rates

  • Japan: 3.24

  • Singapore: 2.29

  • Sweden: 2.76

  • Hong Kong 2.95

  • Cuba 6.22

  • CIA - The World Factbook -- Rank Order - Infant mortality rate


Risk of infant mortality factors l.jpg
Risk of Infant Mortality: Factors

  • If infant mortality rate was similar to Singapore’s we would save over 18,900 infant deaths per year

  • Low Birth Weight largest single factor

    • less than 5.5 pounds (2500 grams)

    • LBW risk factors:

    • K maternal pre-pregnancy ht & wt and pregnancy weight gain

      • age socioeconomic poverty

      • number of pregnancies race


Classification of low birth weight l.jpg
Classification of Low Birth Weight

  • Premature

    • < 37 weeks

  • Intrauterine Growth Retardation or Small for Gestational Age

    • ³37 weeks

      • wasted - thin, ¯wt, normal length

      • stunted - ¯ wt ¯lgth ¯head circum




How to improve infant mortality rate l.jpg
How to improve Infant Mortality Rate?

  • Housing

  • Sanitation

  • Diet

  • Health care


Nutrition influences on fetal growth l.jpg
Nutrition Influences on Fetal Growth

  • Deficiency in Calories

    • Too few Calories to allow adequate reproduction of cells and decreased development

  • Deficiency of Nutrients

    • Too little of some specific nutrient

    • e.g.: folic acid

      • spina bifida



Winick growth happens in two ways l.jpg
Winick: Growth Happens in Two Ways

  • Increased number of cells

  • Increased size of cells

  • Critical times of increased number of cells

    • 1. Increased number hyperplasia

    • 2. Number and size + hypertrophy

    • 3. Size Hypertrophy


Critical periods l.jpg
Critical Periods

  • If an embryo or fetus doesn’t receive the nutrition necessary to help with development, the fetus will suffer

  • Fertilization of the ovum(zygote) happens

    • implantation of the ovum in the uterine wall happens in the first two weeks

    • Critical period: cigarette smoke, malnutrition can keep development from occurring


Types of fetal growth failure l.jpg
Types of Fetal Growth Failure

  • Intrinsic: some internal factor

    • chromosome abnormalities

    • drug affecting cells

  • Extrinsic: some external factor

    • poor intake of nutrients

    • poor blood supply


Is the fetus a perfect parasite l.jpg
Is the fetus a perfect parasite?

  • What does this mean?

    • Fetus takes what it needs regardless of mother’s intake

  • Probably isn’t true.

    • It takes what it needs until it disrupts mother’s ability to survive

  • From a species survival standpoint: mother needs to survive


Events of pregnancy l.jpg
Events of Pregnancy

  • Time Event

  • 0-2 weeks egg fertilized and implanted

  • 3-8 weeks Embryo: at end of 8 weeks is 1 inch and has central nervous system, GI tract, limb, buds, etc.

  • 8-40 weeks Fetal period: growth and development


Role of the placenta l.jpg
Role of the Placenta

  • Nutrient and waste product exchange

  • Hormone production

    • Estrogen: helps develop the infrastructure of pregnancy

    • Progesterone:

      • Relaxes smooth muscle

      • Relaxes the uterus

      • Relaxes the digestive system: slower movement


Placenta roles l.jpg
Placenta Roles

  • Transport Mechanisms:

  • Passive Diffusion:

    • Oxygen -Carbon dioxide

    • Fatty acids -Steroids

    • Nucleosides -Electrolytes

    • Fat-soluble vitamins



Placenta is selectively permeable l.jpg
Placenta is Selectively Permeable

  • Not all molecules can cross the placenta

    • Vitamin D can

    • Parathyroid Hormone (PTH) can’t

    • Allows for bone remodeling


Placental transport l.jpg
Placental Transport

  • Facilitated Diffusion:

    • Most monosaccharides

  • Active Transport:

    • Amino acids --some cations (Ca, Iron)

    • Iodine --Phosphate

    • Water-soluble vitamins (at high concentrations Vitamin C can pass via diffusion)

  • Solvent Drag: electrolytes



Nutrient needs to support pregnancy l.jpg
Nutrient Needs to Support Pregnancy

  • Energy:

    • No increase in Cal for first trimester

      • Why?: 1. Very small embryo; 2. Increased absorption of most nutrients and Cal due to decreased motility of GI tract due to hormones of pregnancy

      • 300 Cal increase during 2nd and 3rd trimester


Nutrient needs during pregnancy l.jpg
Nutrient Needs During Pregnancy

  • Protein:

    • Determine pre-pregnancy needs based on RDA: 0.8 grams protein/kg. This is generally around 45 to 50 grams Protein per day.

      • Add 15 grams to this for pregnancy

      • Generally around 60 to 65 grams/day is sufficient


Slide32 l.jpg

Methylated Molecule

Molecule

SAM

SAH

Homocysteine

Methionine

Methyl-H4 Folate

H4 Folate

B12

serine

glycine

Methylene-H4 Folate

purine

Purine precursor


Nutrients of special interest l.jpg
Nutrients of Special Interest

  • Folate: related to neural tube defects and spina bifida

    • Reduced absorption during pregnancy because of interaction with estrogen

    • Produces folate deficient women

    • Interferes with proper formation of spinal column: affects 400,000 births per year

    • Folate supplements during pregnancy required


Nutrients of special interest34 l.jpg
Nutrients of Special Interest

  • Iron: Blood volume increases by 50% during pregnancy

    • Body conserves Iron during pregnancy

      • No menstruation

      • 3 time increase in absorption

      • But still doesn’t keep up with production of red blood cells

      • Hemoglobin concentration falls: normal above 13 g/dl. In pregnancy may fall below 12 g/dl

      • RDA up from 15 to 30 mg/day


Special supplemental food program for women infants and children l.jpg
Special Supplemental Food Program for Women, Infants, and Children

  • To battle against problems during pregnancy and infancy, WIC was developed to provide supplemental food to low socioeconomic and at risk women and infants.

    • Nutrition education also provided

    • Recent study: for each $1 spent, $4 save down the road;

    • Avg costs: Normal Birth Weight= $1,700; Premie or low birth weight = $77,000


Information on wic l.jpg
Information on WIC Children

  • http://www.fns.usda.gov/wic/

  • In 2005 we had about 8 million receiving WIC assistance in the US; This cost about $1.4 Billion

  • In 2005 we had about 160,000 receiving WIC assistance in Washington; This cost about $28 Million dollars


Body mass index l.jpg
Body Mass Index Children

  • Kg/ meters 2

  • 175#/2.2 #/kg = 79.5 kg

  • 72 “ X .0254 meters/inch = 1.83 meters

  • 1.83 meters 2 = 3.35

    79.5 / 3.35 = 23.7


Weight gain during pregnancy l.jpg
Weight Gain During Pregnancy Children

  • Based on Pre-pregnancy BMI

  • Underweight (BMI<19.8) : 28-40 #

  • Normal weight(BMI 19.8-26) : 25 to 35 #

  • Overweight(BMI 26-29): 15 to 25 #

  • Obese(BMI over 29): 13 # minimum

  • Other Modifiers: Small stature(<62 in) : low end of range; black: high end of range


Wt gain for multifetal pregnancies l.jpg
Wt Gain for multifetal pregnancies Children

  • Twins: 35-45 lbs. Underwt at the upper end of range; overwt at the lower end

    • 4-6 lb first trimester; 1.5 lb/wk after

    • 450 Cal per day above prepregnancy amount

  • Triplets: 50 lbs with 1.5 lb/wk throughout pregnancy

    • Cal intake should reflect enough intake to meet wt gain goals


Average weight of multifetal pregnancies l.jpg
Average weight of multifetal pregnancies Children

  • Singletons: 7.7 lbs(3440 grams)

    • Mean gestational age: 39-40 wks

    • 6% lbw

  • Twins: 5.4 lbs(2400 grams)

    • 37 weeks; 54 % lbw

  • Triplets: 4.0 lbs(1800 grams)

    • 33-34 wks; 90% lbw


Rate of weight gain l.jpg
Rate of Weight Gain Children

  • First Trimester: 2 to 4 pounds

  • Second and Third Trimester: 1 pound per week

  • 3 pounds + (26 weeks x 1 # per week) = 29#


Components of weight gain l.jpg
Components of Weight Gain Children

  • Infant 7.5 # amniotic fluid 2 #

  • Placenta 1.5 # mother’s stores 7 #

  • Blood 4 #

  • Fluid 4 #

  • uterus 2 #

  • Breasts 2 #

  • TOTAL 30 #


Fetal alcohol syndrome l.jpg
Fetal Alcohol Syndrome Children

  • Physical and Mental Abnormalities attributed to alcohol consumption during pregnancy

    • low nasal bridge small head

    • short nose circumference

    • short eyelid opening delayed

    • thin upper lip development

    • underdeveloped filtrum


Source of fas information l.jpg
Source of FAS Information Children

  • http://www.nofas.org/

  • http://capwiz.com/nofas/issues/alert/?alertid=6804721&type=CO

  • Advocacy Extra credit assignment: write a letter to your members of congress


Fas screening l.jpg
FAS Screening Children

  • In 1996, FAS Facial Photographic Screening/Diagnostic software (Astley & Clarren, 1996;2001;Astley et al., 2001;Astley & Kinzel, 2002). The software is used to measure the magnitude of expression of the three facial features of FAS (small eyes, a smooth philtrum and a thin upper lip).


Fas screening46 l.jpg
FAS Screening Children

  • FAS is characterized by growth deficiency, a unique cluster of facial features, cognitive/behavioral problems and prenatal alcohol exposure. The facial appearance is the only feature that is unique to FAS, thus it serves as an ideal feature to use for screening. The screening tool performed with 99.9% accuracy.


Alcohol effects on pregnancy l.jpg
Alcohol Effects on Pregnancy Children

  • About 1/5 of women continue to during pregnancy

    • The first few weeks are critical; many women don’t know they are pregnant

  • Birth defects have occurred in women who consume as little as two drinks per day

    • No alcohol is the best if planning pregnancy

  • Fetal Alcohol Effects: internal damage


Other dietary concerns during pregnancy l.jpg
Other Dietary Concerns during Pregnancy Children

  • Caffeine:

    • Animal models: massive doses are teratogenic

    • Smaller doses not as definitive

      • mixed results in epidemiological studies

      • generally if caffeine is consumed, it should be moderately


Sugar substitutes l.jpg
Sugar Substitutes Children

  • Saccharin: A carcinogen? Limit during pregnancy

    • Doses relationship: high intake = greater risk

  • Aspartame (Nutrasweet):

    • PKU mothers should avoid

    • If not PKU, moderate intake probably ok but need to increase Cal (2nd and 3rd trimesters) and Calcium


Maternal problems of pregnancy l.jpg
Maternal Problems of Pregnancy Children

  • Gestational Diabetes: Glucose Intolerance

    • Hormones of pregnancy make mother’s body resistant to insulin;Human Placental Lactogen (HPL); Human Growth Hormone(HGH)

    • Often shows up at 25 weeks of pregnancy

    • Needs to be treated to control growth of the fetus

    • Macrosomia: large baby and delivery complications


Gestational diabetes dx l.jpg
Gestational Diabetes Dx Children

  • Glucose Tolerance Test (GTT):

  • After Fasting:

    • Glucose Load given orally

    • Baseline Blood Glucose (BG)

    • BG’s every hour for three hours

    • two abnormally high values indicate Db Dx


Normal bg values l.jpg
Normal BG values Children

  • Fasting 105 mg/dl

  • 1 hr 190

  • 2 hr 165

  • 3 hr 145



Treatment of gestational db l.jpg
Treatment of Gestational Db Children

  • Diet alone

    • Calculate CHO needed: Generally 50 % of Cal

      • Could be less if poor control

      • Distribute them throughout the day

      • Develop and Meal Plan for Mother

      • Involves Food Records

      • Weight Checks

      • Ketone Testing

      • Blood Glucose Testing


Gestational db treatment l.jpg
Gestational Db Treatment Children

  • Diet and Insulin

    • Some individuals are never able to control BG by diet alone and require insulin injections

    • Same concerns as diet alone

    • With emphasis on hypoglycemia


Gestational diabetes resources l.jpg
Gestational Diabetes Resources Children

  • American Diabetes Association

  • http://www.diabetes.org/gestational-diabetes.jsp


Other problems of pregnancy l.jpg
Other Problems of Pregnancy Children

  • Edema: most women suffer from water retention: due to large blood volume and decreased protein concentration in blood

  • Pregnancy Induced Hypertension (PIH)

    • massive edema, high blood pressure, protein in urine

    • If untreated can result in fetal and maternal injury or death


Pih formerly called toxemia l.jpg
PIH: formerly called Toxemia Children

  • Elevated BP

  • Proteinuria

  • Massive edema

  • Often called preeclampsia

  • Eclampsia: a result of severe preeclampsia: convulsions and coma Can result in the death of the mother and fetus


Treatment of pih diet l.jpg
Treatment of PIH: Diet?? Children

  • Nutritionally: offset protein loss with additional protein in diet

  • Some research shows calcium supplementation may help prevent; mixed

  • Magnesium supplementation may help

  • Sodium restriction DOES NOT HELP treat or prevent


Treatment of pih diet60 l.jpg
Treatment of PIH: Diet?? Children

  • Antioxidants: Vit C, E, carotene

  • Hypertension often requires blood pressure lowering medication

  • Depending on severity, may require bedrest


Pica and cravings l.jpg
Pica and Cravings Children

  • Pica: Eating Non-foods

    • geophagia: eating dirt

      • Iron deficiency?: problem if it causes a blockage

    • amylophagia: eating clothing starch

  • Cravings:

    • eg: dill pickles and ice cream

    • reason? Overcome a deficiency?

    • No harm, no need for concern: If harmful, intervention is needed


Nutritional guidance during pregnancy l.jpg
Nutritional Guidance During Pregnancy Children

  • Positive approach to nutrition and pregnancy

    • Stress positive outcomes Vs fear of negative outcome

  • Stress the importance of good nutrition

    • adequate protein of good quality

    • enough total Cal, esp CHO, to spare protein

    • balance of vitamins and minerals from fruits and vegies


Nutrition and pregnancy l.jpg
Nutrition and Pregnancy Children

  • Age and Parity of Mother

  • Preconception Nutrition

  • Metabolic Interaction of Pregnancy: synergism

  • Individual needs and adaptations


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Nutrition Assessment Children

  • Clinical Observations

  • Body Measures

  • Lab Tests

  • Diet History


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Lab Tests Can Indicate Problems Children

  • Anemia of Pregnancy

    • Iron Deficiency: Most Common

    • also called microcytic, hypochromic, with reticulocytes( immature RBCs)

    • treated with supplements of Iron (30 mg/day)

  • Other Anemias:

    • Folic Acid deficiencyalso called megaloblastic anemia;

      • disrupts hemoglobin synthesis

    • B12 Deficiency: Called pernicious; also big cells


Blood measures anemia l.jpg
Blood measures: Anemia Children

  • Hematocrit: Packed RBC Volume

    • Normal non-pregnancy: 35 %

    • During pregnancy 29-31%

  • Hemoglobin

    • Normal non-pregnancy: 13-14 g/100ml

    • Pregnancy: 10-11 g/100ml


Images of anemia l.jpg
Images of Anemia Children

  • http://health.allrefer.com/health/iron-deficiency-anemia-reticulocytes.html


Folic acid anemia l.jpg
Folic Acid Anemia Children

  • RDA up from 180 micrograms to 400 micrograms / day

  • Estrogen Folic Acid Interactions

    • 1. Disrupts absorption

      • disrupts an enzyme that helps with absorption(deconjugase)

    • 2. Increases clearance of folic acid from blood


B 12 deficiency l.jpg
B Children12 Deficiency

  • Pernicious Anemia

    • similar to megaloblastic but caused by deficiency of B12

    • If untreated, may also be associated with neurological damage


Slide70 l.jpg


Phenylketonuria and pregnancy l.jpg
Phenylketonuria and Pregnancyhttp://health.allrefer.com/pictures-images/megaloblastic-anemia-view-of-red-blood-cells.html

  • PKU: genetic disease, passed autosomal recessive trait

  • Inability to metabolize extra Phe to Tyrosine

    • missing Phenylalanine hydroxylase

    • results in high phenylketones in mother and fetal circulation

    • can cause mental retardation in fetus


Red flags during assessment l.jpg
Red Flags During Assessmenthttp://health.allrefer.com/pictures-images/megaloblastic-anemia-view-of-red-blood-cells.html

  • Disproportionate height to weight and weight gain

  • Abuse or avoidance of foods

  • bizarre eating patterns

  • economic or psychological problems associated with food

  • unhealthful lifestyle with or without substance abuse


Lactation l.jpg

Lactationhttp://health.allrefer.com/pictures-images/megaloblastic-anemia-view-of-red-blood-cells.html


3 factors to establish and maintain breastfeeding l.jpg
3 Factors to Establish and Maintain Breastfeedinghttp://health.allrefer.com/pictures-images/megaloblastic-anemia-view-of-red-blood-cells.html

  • Anatomy

  • Initiation of production

  • Ejection of milk from alveoli


Anatomy l.jpg
Anatomyhttp://health.allrefer.com/pictures-images/megaloblastic-anemia-view-of-red-blood-cells.html

  • Functional Breasts

  • Large variation in structure

    • But almost all women who have given birth who want to breastfeed their babies can


Development of breasts l.jpg
Development of Breastshttp://health.allrefer.com/pictures-images/megaloblastic-anemia-view-of-red-blood-cells.html

  • Puberty: increased estrogen associated with development of mammary glands and alveolar cells and ducts

  • Pregnancy: further proliferation of alveoli

  • Birth: increase prolactin production and secretion

    • Further alveolar cell proliferation


Physiology of lactation l.jpg
Physiology of Lactationhttp://health.allrefer.com/pictures-images/megaloblastic-anemia-view-of-red-blood-cells.html

  • Full Lactation may not be attained until 2nd or even 3rd week (in first pregnancy)

  • Colostrum: first secretion: high in protein, low in sugar and fat

    • First 2+ days and then transition to milk

    • Yellow

    • high in immunoglobulins


Prolactin control of milk production l.jpg
Prolactin: Control of Milk Productionhttp://health.allrefer.com/pictures-images/megaloblastic-anemia-view-of-red-blood-cells.html

  • Complex neuroendocrine process

  • Sensory nerves of breast stimulated

    • nerve impulse travels to spinal cord and hypothalamus

      • Induces pituitary gland to produce and secrete hormones

        • Major one is PROLACTIN


Cycle of production l.jpg
Cycle of Productionhttp://health.allrefer.com/pictures-images/megaloblastic-anemia-view-of-red-blood-cells.html

  • Resting Cell

  • Milk synthesis

  • Milk secretion

  • Resting Cell


Prolactin control l.jpg
Prolactin Controlhttp://health.allrefer.com/pictures-images/megaloblastic-anemia-view-of-red-blood-cells.html

  • Fat Prolactin increases two enzymes

    • Induces lipoprotein lipase production which removes Triglycerides from circulation and moves fatty acids and glycerol into alveolar cells

    • Induces a transferase enzyme that helps make triglycerides in the cell for milk production


Prolactin control81 l.jpg
Prolactin Controlhttp://health.allrefer.com/pictures-images/megaloblastic-anemia-view-of-red-blood-cells.html

  • Protein: casein and lactalbumin unique to milk

    • Prolactin increases production of these two proteins


Prolactin control82 l.jpg
Prolactin Controlhttp://health.allrefer.com/pictures-images/megaloblastic-anemia-view-of-red-blood-cells.html

  • CHO: lactose

    • Galactosyl transferase(inactive)

    • | lactalbumin

    • |

    • Galactosyl transferase(GT)(active)

    • Glu + Gal-----------> Lactose

    • GT


Maintenance of milk production l.jpg
Maintenance of Milk Productionhttp://health.allrefer.com/pictures-images/megaloblastic-anemia-view-of-red-blood-cells.html

  • Sucking---hypothalamus--anterior pituitary---prolactin secretion---milk production and release

  • If no sucking

    • No milk production

  • Demand and Supply

    • less sucking, less production: more sucking, more production


Milk letdown moving the milk to nipple for baby access l.jpg
Milk Letdown: moving the milk to nipple for baby accesshttp://health.allrefer.com/pictures-images/megaloblastic-anemia-view-of-red-blood-cells.html

  • Controlled by oxytocin

  • Sucking----hypothalamus--posterior pituitary-----oxytocin release

    • myoepithilial cell contraction in ductules

    • forces milk to nipple

  • Other stimuli can induce this as well

    • crying, embarrassment


Human vs cow s milk per liter l.jpg

Kcal: 668http://health.allrefer.com/pictures-images/megaloblastic-anemia-view-of-red-blood-cells.html

Pro(g): 9

% 5.5%

Fat(g): 40

% 53.9%

CHO(g) 68

% 40.7%

678

35

20.6%

38

50.4%

49

28.9%

Human Vs Cow’s milk(per Liter)


Protein content of milk l.jpg
Protein Content of Milkhttp://health.allrefer.com/pictures-images/megaloblastic-anemia-view-of-red-blood-cells.html

  • Species specific: The fastest newborn growth rate = the highest level of protein

    • Cows grow real fast, therefore cow’s milk has relatively more protein than human milk.

    • Why is more protein needed in cow’s milk?


Type of protein in milk l.jpg
Type of protein in milkhttp://health.allrefer.com/pictures-images/megaloblastic-anemia-view-of-red-blood-cells.html

  • Human milk 40 % Casein, 60 % alpha lactalbumin

  • Cow’s milk 80 % Casein, 20 % alpha lactalbumin

  • Human milk low in Phenylalanine

  • Human milk high in cystine & taurine

    • Babies can’t synthesize these too well.


Taurine a conditionally essential amino acid not used in protein synthesis l.jpg
Taurine: a conditionally essential Amino Acid, not used in Protein Synthesis

  • Found free or associated with small peptides:


Taurine function l.jpg
Taurine Function Protein Synthesis

  • Taurine function:

  • Functions: Related to development in infants

  • Also conjugation of bile acids; Taurine, called a bile salt, is lipophilic and hydrophilic; these are conjugated or connected to bile acids, the combination of which helps emulsify the fatty stuff of food and helps with digestion and absorption;


Taurine function90 l.jpg
Taurine Function Protein Synthesis

  • Other functions of taurine:

    • detoxification,

    • membrane stabilization,

    • osmoregulation, and

    • modulation of cellular calcium levels.


Colostrum l.jpg
Colostrum Protein Synthesis

  • High protein

  • low sugar, fat and kcal

  • Immunoglobulins IgA and IgG

    • guard against intestinal tract infection

    • may pass into circulation and guard against systemic infection

  • passage of meconium

  • helps establish bifidus flora in GI tract


Iron supplementation and bf l.jpg
Iron Supplementation and BF Protein Synthesis

  • Two Points of View:

    • Yes: milk iron directly proportional to mother’s intake

      • Fetal Fe levels are generally low;

      • Fe needed for growth

    • No: Fe saturates lactoferrin, the iron binding protein of milk

      • lactoferrin then unable to sequester Fe from pathogenic bacteria; leading to more infections


Vitamins cow vs human l.jpg
Vitamins: Cow Vs. Human Protein Synthesis

  • The amount of vitamins in human milk varies more from individual to individual than does the average vitamin content of cow’s milk from the average vitamin content of human milk. Why?

  • Diet, genetics, other factors


Vitamin k and infants l.jpg
Vitamin K and Infants Protein Synthesis

  • Infants generally low Vitamin K status

  • Intestinal flora make Vitamin K

  • Newborn gut is sterile, no bacteria to make Vitamin K

  • Birth is traumatic

  • Vitamin K is important in blood clotting

  • Vitamin K injection at birth


Breastfeeding best feeding method l.jpg
Breastfeeding: Best Feeding Method Protein Synthesis

  • ‘Sole’ food for the first 4 to 6 months

  • Provides benefits to baby and mother

    • Economic Convenience

    • Nutrition

    • Immune function

    • Bonding

    • Maternal weight loss


Anti infective properties l.jpg
Anti-infective Properties Protein Synthesis

  • Bifidus factor: stimulates bifidobacteria, which fight against pathogenic bacteria

  • IgA, IgM, IgG: immunoglobulins that guard the gut against infective bacteria

  • Lactoferrin: binds iron away from bacteria

  • Macrophages: phagocytosis of infective bacteria

  • B12 binding protein: removes B12 from bac.


When not to breastfeed l.jpg
When not to breastfeed? Protein Synthesis

  • HIV infected mother

    • Although WHO says go ahead in developing countries

      • The risk of infection is less than the harm by not having good nutrition available during early months

  • Galactosemia: one in 50,000 births

    • Inability to convert galactose to glucose and developmental problems result


Breastfeeding promotion l.jpg
Breastfeeding Promotion Protein Synthesis

  • Incidence: how many select breastfeeding as a feeding choice: Breastfeeding at 1 week

  • Duration: how long does mother breastfeed? sole food for 5 to 6 months.

  • By 2000, goals are 85% and 35%

  • Peaked in 1984 at 61% and 24%

  • dropping since

  • Why?


Breastfeeding choice factors l.jpg
Breastfeeding Choice: Factors Protein Synthesis

  • Ethnicity: Anglo 60.5%; Black 25%; Hispanic: 51%;

  • Employment: Full 53 %; Part 62 %; None 53 %;

  • Acculturation: Low 53 %; Middle 38 %; High 36 %;


Trisler t a bergman e a jada suppl 93 9 a77 l.jpg
Trisler, T. A., Bergman, E.A. JADA Suppl 93(9): A77. Protein Synthesis

  • 4 groups of breastfeeding promotion

  • A: no peer present: Spanish taught

  • B: no peer present: English taught

  • C: peer present: Spanish taught

  • D. peer present: English taught

  • Presence of peer played no role in incidence of breastfeeding;

  • Spanish taught increased rate of incidence


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Behavioral Factors Involved in Breastfeeding Decision Protein Synthesis

  • Social Support: availability of family members

  • Social Influence; advertising, health professionals

  • Attitudes:attitudes toward formula and BF

  • Self-efficacy: confidence of the mother

  • Summary: Must increase BF in minority populations


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How to Influence Choice? Protein Synthesis

  • J Nutr Ed: Teaching Intervention 1984: 16(1): 19-22.

  • Three groups:

  • A: Pregnant woman given referral card with telephone number with supportive message

  • B: Same with a manual in Spanish and English

  • C: Same with a bedside teaching session with BF consultant


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JADA 1998;98:143-148. Protein Synthesis

  • Counseling and Motivating videotapes increase duration of breast-feeding in African-American WIC participants

  • n=115 Af-Am women who initiated BF

  • Four groups:

    • A: no intervention B: video package

    • C: peer counseling D: both

  • More breastfed in intervention groups


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JADA 1998 Protein Synthesis

  • Group 7-10 d 8 wk 16 wk

  • Control 53% 23%* 0%*

  • video 67%(n=33)75%(n=28)48%

  • vi&peer 80% 70% 40%

  • *p<.05


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If Breastfeeding is not Chosen? Protein Synthesis

  • Infant formula is next best choice:

    • Most are cow’s milk derived and are produced to be close to human milk in composition

    • Some are soy based

    • Others are specialized to meet certain needs

      • e.g.: PKU babies can’t have very much phenylalanine in the diet: Lofenalac


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Nutrition Education Protein Synthesis

  • Informative: Factual information

  • Attitudinal: motivates change in attitude about nutrition and nourishment

  • Behavioral: motivates change in behavior

  • Therapeutic: addresses a specific problem


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When is Nut Ed needed? Protein Synthesis

  • High Risk Groups: poverty, lack of education, very young(<17yo), very old (over 35 yo), first pregnancy, high parity, prior complications, lack of supportive environment.

  • Education costs money: Cost/benefit needs to be established

    • Money spent saves money


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Cost/Benefit of Nutrition Ed. Protein Synthesis

  • WIC offers nutrition vouchers and nutrition education to high risk mothers.

    • Data collected indicates that for each $1 spent, $4.21 is saved

      • Individuals who don’t receive WIC are at greater risk for low birth weight babies, and other complications that lead to increased health care money spent.

      • Nutrition Education Saves Money!


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Costs of Low Birth Baby Protein Synthesis

  • Medicaid pays an average of $77,000 for a low birth weight baby in additional hospital and health care expenses.

    • A normal weight baby costs an average of $1700.

  • Poor Fetal Nutrition is also linked to Chronic Disease


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Lancet 348:1264-1268, 1996. Protein Synthesis

  • N= 13,249 Death from heart disease and stroke tended to be higher in those men who were born with a low birth weight and remained small at 1 year of age

  • Perhaps related to mother’s ability to support pregnancy and trauma induced in the developing fetus.


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Breastfeeding and Fertility Protein Synthesis

  • Breastfeeding tends to suppress menstruation and ovulation

  • Almost all who formula feed initiate menstruation and ovulation sooner

  • Can this be used as a contraceptive method?

  • Probably not. Nutritional status also influences.


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When to Add Solid Foods? Protein Synthesis

  • 4 to 6 months: when developmental landmarks are met; Continue breastfeeding or formula

  • Iron fortified rice cereal

  • Add one food at a time: several days

    • See if there is an allergic reaction

    • Then add a new food


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Problems of Infant Feeding Protein Synthesis

  • Failure to Thrive:

    • Baby doesn’t grow as fast as peers

    • Causes? Often inadequate nutrition

    • Monitor weight gain

    • Compare nutrient intake per body weight

      • A baby needs more than an adult


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Problems of Infant Feeding Protein Synthesis

  • Baby Bottle Tooth Decay: Also called Nursing Bottle Syndrome

    • Exposure of teeth to the carbohydrates of formula


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General Feeding Rules for Infants and Children Protein Synthesis

  • Caregiver is the gatekeeper: What is offered and when

  • Infant or child decides whether to eat what is offered and also how much


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This is The New Font Color Protein Synthesis


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