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Benign Transient Hyperphosphatasaemia

Introduction. Marked increase in Alkaline Phosphatase . Normalises within around 12 weeks. Incidental finding but often raised to an alarming level. Increase in both liver and bone fractions. Benign

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Benign Transient Hyperphosphatasaemia

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    1. Benign Transient Hyperphosphatasaemia Lynn Rowbottom January 2007

    3. Suggested causes Increased activity of normal amount of enzyme

    4. Seasonal presentation

    5. Suggested causes Enzyme release from tissues

    6. 3 suspected BTH cases Randomly identified

    7. Case 1: Male DOB:17/10/03 “Jaundiced ? Hep A”

    8. Case 1 ALP Electrophoresis

    9. Case 2: Female DOB:17/07/04 “Bony lump on chest and alk phos high”

    10. Case 2 Isoenzyme Electrophoresis

    11. Case 3: Male DOB: 07/03/05 “Bruising. URTI?”

    13. Summary

    15. Conclusion Be aware of BTH in children AND adults Benign and transient Unusual sialoforms may prove useful in the diagnosis of this condition ? ALP in acute phase response

    16. Acknowledgements Christopher Reeves, Katharine Hayden & Ian Watson, University Hospital Aintree Elaine Kerr, Alder Hey Children’s Hospital Andrew Davison & Tony Stott, Royal Liverpool University Hospital Thank you for listening!

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