ENABLING TRANSLATION
Download
1 / 13

Presentation File - PowerPoint PPT Presentation


  • 289 Views
  • Updated On :

ENABLING TRANSLATION INSTITUTE FOR CANCER/STEM CELL BIOLOGY AND MEDICINE. Stanford School of Medicine Leadership Retreat January 29-31, 2004. Background. Created in December 2002 Purpose: To advance fundamental research in cancer and stem cell biology

loader
I am the owner, or an agent authorized to act on behalf of the owner, of the copyrighted work described.
capcha
Download Presentation

PowerPoint Slideshow about 'Presentation File' - Melvin


An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -
Presentation Transcript
Slide1 l.jpg

ENABLING TRANSLATION

INSTITUTE FOR CANCER/STEM CELL BIOLOGY AND MEDICINE

Stanford School of Medicine Leadership Retreat

January 29-31, 2004


Background l.jpg
Background

  • Created in December 2002

  • Purpose:

    • To advance fundamental research in cancer and stem cell biology

    • To translate discoveries to preclinical paradigms

    • To organize efforts throughout the University

      • To enhance our understanding of human diseases

      • To improve patient care

  • Past Stanford-affiliated Accomplishments:

    • First prospective isolation of mouse hsc (1988)

    • First isolation of human hsc (1991)

    • First isolation of mouse and human hematopoietic progenitors (2000)

    • First prospectively isolated brain-forming (CNS) stem cells (2000)

    • Fruit fly sperm-forming stem cell identified (1999)


Discovery translation therapy l.jpg
Discovery => Translation => Therapy

Example: Breast Cancer

  • Cancer-free human stem cells isolated and stored from patients with Stage IV breast cancer

  • Post-chemotherapy, stored hsc used to regenerate blood-forming system in patients

  • Blood-forming system regenerated in ≈ 2 weeks

  • Survival rates and cancer recurrence rates are much higher than expected from normal therapies

  • Future: Search for breast cancer stem cells, and define targets for diagnosis, molecular therapeutics, and immunotherapeutics by expression arrays and proteomics.

  • Similar experiences with non-Hodgkin’s Lymphomas


Discovery translation therapy4 l.jpg
Discovery => Translation => Therapy

Promising Animal Models (at Stanford) for studying and using hematopoietic and CNS stem cells, and new tissue stem/progenitor cells:

  • Spinal Cord Injury, Cerebrovascular stroke

  • Genetic diseases leading to brain degeneration

  • Transplant Rejection improvements in

    • Heart Transplants

    • Pancreatic Insulin-Producing Islet Cells

    • Skin Grafts

    • Liver

  • Juvenile Type 1 diabetes

  • Infectious diseases of CNS (Arvin) and BMT (Brown)


New stem cell opportunities l.jpg
New Stem Cell Opportunities

Through the Institute for Cancer/Stem Cell Biology and Medicine, we will:

  • Identify and recruit the best young stem cell biologists who wish to find new organ or tissue stem cells (lung, peripheral nervous system, skin, liver, pancreas, kidney, etc.)

  • Identify and appoint Associates and Affiliates.

  • Develop Affiliate ‘hotel’ space in CSCI to improve collaborations.

  • Establish research models to produce human pluripotent stem cells from patients with genetically determined diseases

  • Provide specialized research models and rigor to do it right the first time

  • Provide specialized instrumentation

  • Provide a vehicle for deeply-interested physicians, residents, graduate students, postdocs and, under the new curriculum, medical student scholars to form translational teams.

  • Establish educational programs for larger community.


Comprehensive cancer center role l.jpg
Comprehensive Cancer Center Role

  • Discovery of cancer stem cells and the protooncogenes activated in them is a convergence of:

    • Classic stem cell biologists

    • Classical cancer gene biologists

    • Cancer and Leukemia oncologists

  • Stanford approach to cancer and cancer stem cell biology:

    • Recruit 1 or more of the best cancer stem cell biologists in the world

    • Extend the tools of cancer stem cell biology to each of the cancers commonly treated at Stanford

    • Recruit to Stanford 1-2 of the best cancer gene biologists

    • Establish Stanford as an NCI-designated Comprehensive Cancer Center and recruit and outstanding leader


Slide7 l.jpg

The new Stanford Cancer Center, the Institute and NCI

designation create a comprehensive approach to cancer:

Stanford

Hospital & Clinics

& LPCH

Clinical Care

School of Medicine

Research

Institute for Cancer/Stem Cell Biology and Medicine

Translational

NCI-Designated Comprehensive Cancer

Center

Research


Slide8 l.jpg

Examples of Current Translational Collaborations

NEW COLLABORATIVE RESEARCH PROGRAMS TO IDENTIFY AND ISOLATE HUMAN CANCER AND LEUKEMIA STEM CELLS

  • Brain Cancers: Griff Harsh, Steve Huehn, Steve Skirboll,Victor Tse, Sam Cheshier

  • Ovarian Cancers: Nelson Teng, Amreen Hussein

  • Lung Cancers: Glenn Rosen

  • Bladder, Prostate, and Kidney Cancers: Joe Presti, Linda Shortliffe

  • Uterine Cancers and Endometriosis: Linda Giudice

  • Acute and Chronic Myelogenous Leukemias: Catriona Jamieson, Robert Lowsky, Peter Greenberg

  • Breast Cancers: Matt van der Rijn, Michael Clarke (Michigan), Stephanie Jeffries, Jonathan Pollock

  • Head and Neck (tentative): Fee, Goode, Quynh-Thu Le


Slide9 l.jpg

Examples of Current Translational Collaborations

COLLABORATIONS TO FIND TISSUE STEM CELLS

  • Pancreatic islets: Seung Kim and Roel Nusse

  • Cerebellum: Matt Scott

  • Bladder: Linda Shortliffe

  • Endometrium: Linda Giudice

  • Mesenchymal: Mike Longaker

  • Neural: Bill Mobley and Ann Arvin (ID)

  • Cardiac: Bobby Robbins

  • Hematopoietic progenitors: Wes Brown (ID)


Examples of current translational collaborations l.jpg
Examples of Current Translational Collaborations

COLLABORATIONS TO FIND PROGENITOR CELLS IN THE IMMUNE SYSTEM

  • Dendritic cells: Ed Engleman and Miriam Merad

  • Precursor T cells: Sam Strober

  • Precursor B cells: Erik Ranheim

  • Marrow-engrafting facilitator cells: Judy Shizuru


Current translational collaborations examples l.jpg
Current Translational Collaborations: Examples

IMAGING AND EXPANDING BLOOD-FORMING STEM CELLS

  • Imaging: Chris Contag, Sam Gambhier

  • Expansion: Roel Nusse, Mark Kay


Priority hires over next several years l.jpg
Priority hires over next several years

  • Cancer Center Director (in progress)

  • Senior appointment in pluripotent stem cell biology (as soon as space is available)

  • Senior Cancer Stem Cell Physician Scientist (as soon as space is available)

  • Cancer gene scientist in collaboration with Cancer Center Director (in 1-3 years, if space is available)

  • Junior stem cell biologists (in 1-4 years as space becomes available); best possible at a fundamental level, but optimally in a field that can be translated


Next steps l.jpg
Next Steps

  • Help raise funds for SIM 1

  • Raise funds for CSCI recruitments, endowments, common core specialized instrumentation, funding for ‘hotel space’ labs in CSCI.

  • Recruitments as detailed.

  • With Steering Committee, begin process of identifying internal candidates for Associate positions in CSCI.

  • With Steering Committee canvas current university faculty for Affiliate positions in CSCI, and choose affiliates.


ad