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The 200 7 Prohibited List of Substances and Methods. By: Mohammad Reza, SHARIF, MD [email protected] In competition Substances: S1. Anabolic Agents S2. Hormones and related Substances S3. Beta-2 Agonists S4. Agents with Anti-Estrogenic Activity

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the 200 7 prohibited list of substances and methods2
In competition

Substances:

S1. Anabolic Agents

S2. Hormones and related Substances

S3. Beta-2 Agonists

S4. Agents with Anti-Estrogenic Activity

S5. Diuretics and other Masking Agents

S6. Stimulants

S7. Narcotics

S8. Cannabinoids

S9. Glucocorticosteroids

Methods:

M1. Enhancement of Oxygen Transfer

M2. Chemical and Physical Manipulation

M3. Gene Doping

In and out of competition (at all times)

Substances:

S1

S2

S3

S4

S5

*

*

*

*

Methods:

M1

M2

M3

Sharif

The 2007 Prohibited List of Substances and Methods
s1 anabolic agents
S1. Anabolic Agents

Anabolic Agents:

1. Anabolic Androgenic Steroids (AAS)

a. Exogenous ( not capable of being produced by the body naturally )

b. Endogenous ( capable of being produced by the body naturally )

2. Other Anabolic Agents

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The drugs classified under the name of AAS are derived from male sexual hormone (androgen)

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The other Anabolic Agents are anabolic with no androgenic effects because of different mechanism and origin with AAS group

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Sharif

anabolic androgenic steroids aas
Exogenous:

Boldenone

Boldione

Clostebol

Danazol

Ethylestrenol

Fluoxymesterone

Gestrinone

Methandienone

Methyltestosterone

Nandrolone

Oxabolone

Oxandrolone

Oxymetholone

Stanozolol

Tetrahydrogestrinone

And the other substances with a similarchemical structure or similar biological effect(s).

Endogenous:

Andrestenedione

Dehydroepiandrosterone (DHEA)

Dihydrotestosterone (DHT)

Testosterone

And the relating metabolites and isomers.

Sharif

Anabolic Androgenic Steroids (AAS)
other anabolic agents
Other Anabolic Agents
  • Clenbuterol
  • Tibolone
  • Zeranol
  • Zilpaterol

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These substances have definite anabolic effects with various mechanisms but no androgenic manifestations.

---------------------------------------------------------------------------------------------------------------------

Sharif

s2 hormones and related substances
S2. Hormones and related Substances

1. Erythropoietin (EPO)

2. Growth Hormone (hGH), Insulin-like Growth Factor (IGF-1),

Mechano Growth Factors (MGFs)

3. Gonadotrophins (LH, hCG), prohibited in males only

4. Insulin

5. Corticotrophins

And the other substances with a similar chemical structure or similar biological effect(s), and their releasing factors which will be reported as an Adverse Analytical Finding.

Sharif

s3 beta 2 agonists
S3. Beta-2 Agonists

Their use requires a Therapeutic Use Exemption.

As an exemption: (only)

  • Formoterol
  • Salbutamol
  • Salmeterol
  • Terbutaline

When administered by inhalation to prevent and/or treat asthma and exercise-induced asthma/broncho-constriction require an abbreviated TUE.

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Despite the granting of a TUE, is prohibited:

  • All the beta-2 agonists expecting the above exemptions
  • Reported concentration of salbutamol > 1000 ng/ml = Adverse Analytical Finding unless the athlete proves that the abnormal result was the consequence of the therapeutic use of inhaled salbutamol

---------------------------------------------------------------------------------------------------------------

Sharif

s4 agents with anti estrogenic activity
S4. Agents with Anti-Estrogenic Activity

1. Aromatase inhibitors:

  • Anastrozole
  • Letrozole
  • Aminogluthetimide
  • Exemestane
  • Formestane
  • Testolactone

2. Selective Estrogen Receptor Modulators (SERMs):

  • Raloxifene
  • Tamoxifen
  • Toremifene

3. Other anti-estrogenic substances:

  • Clomiphene
  • Cyclofenil
  • Fulvestrant

Sharif

s5 diuretics and other masking agents
S5. Diuretics and other Masking Agents

Masking Agents:

  • Diuretics (acetazolamide, amiloride, chlortalidone, etacrynic acid, furosemide, metolazone, spironolactone, hydrochlorothiazide, triamterene, …)
  • Epitestosterone
  • Probencid
  • Alpha-reductase inhibitors (finasteride, dutasteride, …)
  • Plasma expanders (albumin, dextran, hydroxyl starch, …)

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For diuretics, a TUE is not valid if an athlete’s urine contains a diuretic in association with threshold or sub-threshold levels of a prohibited substance(s).

-----------------------------------------------------------------------------------------------

Sharif

s6 stimulants
S6. Stimulants

Only in Competitions

Stimulants:

  • Adrafinil
  • Adrenaline
  • Amphetamine
  • Bromantan
  • Cathine
  • Cocaine
  • Ephedrine
  • Fenfluramine
  • Fenproporex
  • Methylphenidate
  • Modafinil
  • Nikethamide
  • Pemoline
  • Selegiline
  • Strychnine
  • Tuaminoheptane

And other similar substances

Sharif

s7 narcotics s8 cannabinoids
Narcotics:

Buprenorphine

Dextromoramide

Diamorphine (heroin)

Fentanyl and its derivatives

Hydromorphone

Metadone

Morphine

Oxycodone

Oxymorphone

Pentazocine

Pethidine

Sharif

Cannabinoids:

Hashish

Marijuana

S7. NarcoticsS8. Cannabinoids
s9 glucocorticosteroids
S9. Glucocorticosteroids

Glucocorticosteroids:

  • Betamethasone
  • Prednisolone
  • Methylprednisolone
  • Triamcinolone
  • Hydrocortisone

--------------------------------------------------------------------------------------------------------------------------------

Are prohibited when administered:

  • Orally
  • Rectally (not anal)
  • Intravenously
  • Intramuscularly

Their use requires TUE approval.

--------------------------------------------------------------------------------------------------------------------------------

All other routes of administration require an abbreviated TUE, e.g. intraarticular, periarticular, peritendinous, epidural, intradermal injections and inhalation

--------------------------------------------------------------------------------------------------------------------------------

Dermatological and anal preparations are not prohibited.

--------------------------------------------------------------------------------------------------------------------------------

Sharif

m1 enhancement of oxygen transfer
M1. Enhancement of Oxygen Transfer

a. Blood doping:

autologous, homologous or heterologous blood or red blood cell products of any origin, other than for medical treatment.

b. Artificially enhancing the uptake, transport or delivery of oxygen:

perfluorochemicals, efaproxiral (RSR13) and modified haemoglobin products (haemoglobin-based blood substitutes, microencapsulated haemoglobin products).

Sharif

m2 chemical and physical manipulation
M2. Chemical and Physical Manipulation

Tampering, or attempting to tamper, in order to alter integrity and validity of Samples collected in Doping Controls.

  • Intravenous infusions
  • Catheterization
  • Urine substitution

And similar issues.

---------------------------------------------------------------------------------------------------------------------

Except as a legitimate acute medical treatment, IV infusions are prohibited.

---------------------------------------------------------------------------------------------------------------------

Sharif

m3 gene doping
M3. Gene Doping

Enhancement of athletic performance through the non-therapeutic use of:

  • Cells
  • Genes
  • Genetic elements
  • Modulation of gene expression

Sharif

substances prohibited in particular sports
Substances Prohibited inParticular Sports

P1. Alcohol (ethanol)

  • Prohibited in-competition only
  • Detection by analysis of breath and/orblood
  • The doping violation threshold(hematological values)for eachFederation is different

P2. Beta-blockers

  • Prohibited in-competition only, unless otherwise specified

Sharif

slide19
Beta-blockers:

Acebutolol

Alprenolol

Atenolol

Betaxolol

Bisoprolol

Bunolol

Carteolol

Carvedilol

Celiprolol

Esmolol

Labetalol

Levobunolol

Metipranolol

Metoprolol

Nadolol

Oxprenolol

Pindolol

Propranolol

Sotalol

Timolol

Sharif

specified substances
Specified Substances

Particularly susceptible to unintentional anti-doping rule violations because of their general availability in medical products or less likely to be successfully abused as doping agents.

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A doping violation involving such substances may result in a reduced sanction provided that the “… Athlete can establish that the Use of such a specified substance was not intended to enhance sport performance …”

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Specified Substances:

  • Ephedrine, L-methylamphetamine, methylamphetamine, cathine, cropropamide and any other stimulant not expressly listed under section S6
  • Cannabinoids;
  • All inhaled Beta-2 Agonists, except clenbuterol at any level and salbutamol at urinary level>1000 ng/ml
  • Probencid
  • All Glucocorticosteroids;
  • All Beta Blockers;
  • Alcohol;

Sharif

thanks a lot
Thanks a lot

Mohammad Reza, Sharif M.D.

  • WADA independent observer
  • Olympic Council of Asia

ADC member

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[email protected]

(98) 912 193 6404

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