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The 200 7 Prohibited List of Substances and Methods. By: Mohammad Reza, SHARIF, MD [email protected] In competition Substances: S1. Anabolic Agents S2. Hormones and related Substances S3. Beta-2 Agonists S4. Agents with Anti-Estrogenic Activity

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The 200 7 prohibited list of substances and methods l.jpg

The 2007 Prohibited List of Substances and Methods

By:

Mohammad Reza, SHARIF, MD

[email protected]


The 200 7 prohibited list of substances and methods2 l.jpg

In competition

Substances:

S1. Anabolic Agents

S2. Hormones and related Substances

S3. Beta-2 Agonists

S4. Agents with Anti-Estrogenic Activity

S5. Diuretics and other Masking Agents

S6. Stimulants

S7. Narcotics

S8. Cannabinoids

S9. Glucocorticosteroids

Methods:

M1. Enhancement of Oxygen Transfer

M2. Chemical and Physical Manipulation

M3. Gene Doping

In and out of competition (at all times)

Substances:

S1

S2

S3

S4

S5

*

*

*

*

Methods:

M1

M2

M3

Sharif

The 2007 Prohibited List of Substances and Methods


S1 anabolic agents l.jpg
S1. Anabolic Agents

Anabolic Agents:

1. Anabolic Androgenic Steroids (AAS)

a. Exogenous ( not capable of being produced by the body naturally )

b. Endogenous ( capable of being produced by the body naturally )

2. Other Anabolic Agents

----------------------------------------------------------------------------------------------------------------------------------------

The drugs classified under the name of AAS are derived from male sexual hormone (androgen)

----------------------------------------------------------------------------------------------------------------------------------------

The other Anabolic Agents are anabolic with no androgenic effects because of different mechanism and origin with AAS group

----------------------------------------------------------------------------------------------------------------------------------------

Sharif


Anabolic androgenic steroids aas l.jpg

Exogenous:

Boldenone

Boldione

Clostebol

Danazol

Ethylestrenol

Fluoxymesterone

Gestrinone

Methandienone

Methyltestosterone

Nandrolone

Oxabolone

Oxandrolone

Oxymetholone

Stanozolol

Tetrahydrogestrinone

And the other substances with a similarchemical structure or similar biological effect(s).

Endogenous:

Andrestenedione

Dehydroepiandrosterone (DHEA)

Dihydrotestosterone (DHT)

Testosterone

And the relating metabolites and isomers.

Sharif

Anabolic Androgenic Steroids (AAS)


Other anabolic agents l.jpg
Other Anabolic Agents

  • Clenbuterol

  • Tibolone

  • Zeranol

  • Zilpaterol

    ---------------------------------------------------------------------------------------------------------------------

    These substances have definite anabolic effects with various mechanisms but no androgenic manifestations.

    ---------------------------------------------------------------------------------------------------------------------

    Sharif


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S2. Hormones and related Substances

1. Erythropoietin (EPO)

2. Growth Hormone (hGH), Insulin-like Growth Factor (IGF-1),

Mechano Growth Factors (MGFs)

3. Gonadotrophins (LH, hCG), prohibited in males only

4. Insulin

5. Corticotrophins

And the other substances with a similar chemical structure or similar biological effect(s), and their releasing factors which will be reported as an Adverse Analytical Finding.

Sharif


S3 beta 2 agonists l.jpg
S3. Beta-2 Agonists

Their use requires a Therapeutic Use Exemption.

As an exemption: (only)

  • Formoterol

  • Salbutamol

  • Salmeterol

  • Terbutaline

    When administered by inhalation to prevent and/or treat asthma and exercise-induced asthma/broncho-constriction require an abbreviated TUE.

    ---------------------------------------------------------------------------------------------------------------

    Despite the granting of a TUE, is prohibited:

  • All the beta-2 agonists expecting the above exemptions

  • Reported concentration of salbutamol > 1000 ng/ml = Adverse Analytical Finding unless the athlete proves that the abnormal result was the consequence of the therapeutic use of inhaled salbutamol

    ---------------------------------------------------------------------------------------------------------------

    Sharif


S4 agents with anti estrogenic activity l.jpg
S4. Agents with Anti-Estrogenic Activity

1. Aromatase inhibitors:

  • Anastrozole

  • Letrozole

  • Aminogluthetimide

  • Exemestane

  • Formestane

  • Testolactone

    2. Selective Estrogen Receptor Modulators (SERMs):

  • Raloxifene

  • Tamoxifen

  • Toremifene

    3. Other anti-estrogenic substances:

  • Clomiphene

  • Cyclofenil

  • Fulvestrant

    Sharif


S5 diuretics and other masking agents l.jpg
S5. Diuretics and other Masking Agents

Masking Agents:

  • Diuretics (acetazolamide, amiloride, chlortalidone, etacrynic acid, furosemide, metolazone, spironolactone, hydrochlorothiazide, triamterene, …)

  • Epitestosterone

  • Probencid

  • Alpha-reductase inhibitors (finasteride, dutasteride, …)

  • Plasma expanders (albumin, dextran, hydroxyl starch, …)

    -----------------------------------------------------------------------------------------------

    For diuretics, a TUE is not valid if an athlete’s urine contains a diuretic in association with threshold or sub-threshold levels of a prohibited substance(s).

    -----------------------------------------------------------------------------------------------

    Sharif


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S6. Stimulants

Only in Competitions

Stimulants:

  • Adrafinil

  • Adrenaline

  • Amphetamine

  • Bromantan

  • Cathine

  • Cocaine

  • Ephedrine

  • Fenfluramine

  • Fenproporex

  • Methylphenidate

  • Modafinil

  • Nikethamide

  • Pemoline

  • Selegiline

  • Strychnine

  • Tuaminoheptane

    And other similar substances

    Sharif


S7 narcotics s8 cannabinoids l.jpg

Narcotics:

Buprenorphine

Dextromoramide

Diamorphine (heroin)

Fentanyl and its derivatives

Hydromorphone

Metadone

Morphine

Oxycodone

Oxymorphone

Pentazocine

Pethidine

Sharif

Cannabinoids:

Hashish

Marijuana

S7. NarcoticsS8. Cannabinoids


S9 glucocorticosteroids l.jpg
S9. Glucocorticosteroids

Glucocorticosteroids:

  • Betamethasone

  • Prednisolone

  • Methylprednisolone

  • Triamcinolone

  • Hydrocortisone

    --------------------------------------------------------------------------------------------------------------------------------

    Are prohibited when administered:

  • Orally

  • Rectally (not anal)

  • Intravenously

  • Intramuscularly

    Their use requires TUE approval.

    --------------------------------------------------------------------------------------------------------------------------------

    All other routes of administration require an abbreviated TUE, e.g. intraarticular, periarticular, peritendinous, epidural, intradermal injections and inhalation

    --------------------------------------------------------------------------------------------------------------------------------

    Dermatological and anal preparations are not prohibited.

    --------------------------------------------------------------------------------------------------------------------------------

    Sharif


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M1. Enhancement of Oxygen Transfer

a. Blood doping:

autologous, homologous or heterologous blood or red blood cell products of any origin, other than for medical treatment.

b. Artificially enhancing the uptake, transport or delivery of oxygen:

perfluorochemicals, efaproxiral (RSR13) and modified haemoglobin products (haemoglobin-based blood substitutes, microencapsulated haemoglobin products).

Sharif


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M2. Chemical and Physical Manipulation

Tampering, or attempting to tamper, in order to alter integrity and validity of Samples collected in Doping Controls.

  • Intravenous infusions

  • Catheterization

  • Urine substitution

    And similar issues.

    ---------------------------------------------------------------------------------------------------------------------

    Except as a legitimate acute medical treatment, IV infusions are prohibited.

    ---------------------------------------------------------------------------------------------------------------------

    Sharif


M3 gene doping l.jpg
M3. Gene Doping

Enhancement of athletic performance through the non-therapeutic use of:

  • Cells

  • Genes

  • Genetic elements

  • Modulation of gene expression

    Sharif


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Substances Prohibited inParticular Sports

P1. Alcohol (ethanol)

  • Prohibited in-competition only

  • Detection by analysis of breath and/orblood

  • The doping violation threshold(hematological values)for eachFederation is different

    P2. Beta-blockers

  • Prohibited in-competition only, unless otherwise specified

    Sharif




Slide19 l.jpg

Beta-blockers:

Acebutolol

Alprenolol

Atenolol

Betaxolol

Bisoprolol

Bunolol

Carteolol

Carvedilol

Celiprolol

Esmolol

Labetalol

Levobunolol

Metipranolol

Metoprolol

Nadolol

Oxprenolol

Pindolol

Propranolol

Sotalol

Timolol

Sharif


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Specified Substances

Particularly susceptible to unintentional anti-doping rule violations because of their general availability in medical products or less likely to be successfully abused as doping agents.

---------------------------------------------------------------------------------------------------------------------

A doping violation involving such substances may result in a reduced sanction provided that the “… Athlete can establish that the Use of such a specified substance was not intended to enhance sport performance …”

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Specified Substances:

  • Ephedrine, L-methylamphetamine, methylamphetamine, cathine, cropropamide and any other stimulant not expressly listed under section S6

  • Cannabinoids;

  • All inhaled Beta-2 Agonists, except clenbuterol at any level and salbutamol at urinary level>1000 ng/ml

  • Probencid

  • All Glucocorticosteroids;

  • All Beta Blockers;

  • Alcohol;

    Sharif


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Thanks a lot

Mohammad Reza, Sharif M.D.

  • WADA independent observer

  • Olympic Council of Asia

    ADC member

    -------------------------------------------

    [email protected]

    (98) 912 193 6404

    -------------------------------------------


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