The Effects of Deleting Cytosolic Thioredoxin Reductase on p53 Target Gene Expression. Sydney Radding Dr. Gary Merrill Dept. Of Biochemistry/Biophysics. Cancer. Responsible for 25% of all deaths Causes: Carcinogens Random errors in DNA replication Inherited abnomalities.
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Dr. Gary MerrillDept. Of Biochemistry/Biophysics
NADPH p53 Target Gene Expression
P21, mdm2, Gadd45, Bax, PUMA
Cytosolic thioredoxin reductase is needed for efficient target gene activation by p53
Experiment p53 Target Gene Expression
* p53 Target Gene Expression