Opiate Receptor Pharmacology. Donald R. Wesson, MD. Opiate Receptors and effect of Agonist. Schematic of Mu Opiate Receptor. Source: Goodman and Gillman 9 th ed, p. 526. Agonist Partial Agonist Antagonists. Morphine-like effect (e.g., heroin, weak binding except for Fentanyl)
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Donald R. Wesson, MD
Source: Goodman and Gillman 9th ed, p. 526
Morphine-like effect (e.g., heroin, weak binding except for Fentanyl)
Weak morphine-like effects with strong receptor affinity (e.g., buprenorphine)
No effect in absence of an opiate or opiate dependence (e.g., naltrexone)Receptor Binding at Mu receptor
AntagonistEffect of Common Opiates at Mu Receptor