Canary courtship the story of neurogenesis
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Canary Courtship The Story of Neurogenesis. with Susan Wehry, M.D. . Images of Aging. Images of Aging. STOP AGING NOW!. AGE WELL NOW. The brain can’t make new cells, RIGHT?. WRONG. What’s new about being old?. Neuronal plasticity Variability Modifiability. Genesis…Neuro style.

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Canary Courtship The Story of Neurogenesis

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Canary CourtshipThe Story of Neurogenesis

with

Susan Wehry, M.D.


Images of Aging


Images of Aging

STOP AGING NOW!

AGE WELL NOW


The brain can’t make new cells, RIGHT?

WRONG


What’s new about being old?

  • Neuronal plasticity

  • Variability

  • Modifiability


Genesis…Neuro style


The Songbird Story

  • Fernando Nottenbohm

  • 1980’s, Rockefeller University

  • Song center  spring

  • Hippocampus  fall


The Songbird Skeptics

  • Restricted throughout evolution

  • New neurons would disrupt

  • No primate neurogenesis


The Primate Story

  • Elizabeth Gould

  • Bruce McEwen

  • Hippocampus

    • Tree shrew

    • Marmoset

    • Rhesus monkey

  • Neocortex


The Human Story

  • Fred Gage

  • Cancer patients

  • Neurogenesis

    • human hippocampus


Do they work?

  • Enriched environments 

    • heavier brains

    •  synapses

    •  branching

    •  learning

      Even in very old mice


Neurogenesis

  • Stimulated by

    • Enriched environments

      • toys and friends

    • Participation in learning

    • Physical exercise


Neurogenesis

  • Inhibited by

    • Isolation

    • Stress


What About Us?


The Aging Brain

  • Knowledge in transition

  • Tremendous variation

    • Within the brain

    • Between individuals


Components

Dendrites

Cell body

Synapse

Axon


Neurons

100,000,000,000

ONE HUNDRED BILLION


Synapses

10,000s /neuron

104 X 1011

=

1,000,000,000,000,000


ONE

Quadrillion


And we lose maybe

10,000/day


The Brain responds

  • Neurogenesis

  • Synapses reorganize

  • Dendrites sprouting


The Human Hippocampus

  • Main relay station

    • New memory

      • Long term storage

      • Discard


The Human Hippocampus

  • London Taxi Drivers

    • Enlarged

    • Right activated routes

  • Dementia, Alzheimer’s type

    • Smaller volume


The Aging Brain

  • Decrease in brain weight

    • Plasticity >  Neurons

  • Function

    • Less efficient

    • Slower rate

    • No change in total learning

  • Modifiable


Successful Aging

  • MacArthur Foundation

    • Genetic factors < 50%

    • Education strongest predictor

  • Health

    • Physical/mental

  • Optimism/Self-efficacy

  • Social support


Successful aging


Barriers to successful aging

As we age, our expectations change:

  • we demand less and less of our brains

  • we link our absentmindedness to age

  • we accept ageist stereotypes


Remove the Barriers

  • Alter expectations

  • Develop a strategy


Take Stock

  • Illness inventory

  • Health inventory

  • Stress inventory


Change Behavior

  • Make a pledge

  • Identify goal

  • Visualize undertaking


Change Behavior

  • Plan for success

  • Set up a routine

  • Engage a partner

  • Get started


EXERCISE

BODY

BRAIN


PRACTICE

Remembering

Thinking

Problem-solving


Strategies

  • Maintain health

    • Physical

    • Mental

  • Stay connected

  • Active life style

  • Nutrition

  • Enrich environment


You heard it here!

  • Use it or lose it

    “That which is used develops,

    that which is not used,

    wastes away”

    (Hippocrates 460-337 B.C.)


You heard it here!

  • Story of neurogenesis

  • Knowledge

    • aging human brain

    • successful aging

  • Strategies


You heard it here!

  • Alter expectation

  • Remember mama

  • Stay connected


To learn more or just to stay in touch

Please visit my website

www.susanwehrymd.com


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