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CRITICAL PERIOD. Modified from MacLusky and Naftolin Science 1981; 211:1294 - 1303. OH. Testosterone. O. Aromatase. 5 a - Reductase. OH. HO. O. Estradiol. 5 a - DHT. Androgen-dependent sexual dimorphism in the CNS. Ultrastructural differences Neuronal nuclear and nucleolar size

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Critical period l.jpg
CRITICAL PERIOD

Modified from MacLusky and Naftolin Science 1981; 211:1294 - 1303


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OH

Testosterone

O

Aromatase

5a - Reductase

OH

HO

O

Estradiol

5a - DHT


Androgen dependent sexual dimorphism in the cns l.jpg
Androgen-dependent sexual dimorphism in the CNS

  • Ultrastructural differences

    • Neuronal nuclear and nucleolar size

  • Differences in synaptic or dendritic organization

  • Differences in the gross volume of defined cell groups




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CELL MIGRATION

A

B

Arnold and Gorski 1984


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10 20 30 12 36 60 Age (weeks) Time (hr)


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