www.brainage.med.unsw.edu.au. THE BRAIN AND AGEING PROGRAM. University of New South Wales Southeastern Sydney Illawara Area Health Service Neuropsychiatric Institute Department of Old Age Psychiatry Prince of Wales Hospital. BRAIN AND AGEING PROGRAM. Primary aims
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Madame Jeanne Calment of Arles, France, photographed in 1994 at the age of 119. She died in 1997, aged 122, of ‘natural causes’.
“Living independently until the age of 110….. Despite visual and hearing loss, she maintained autonomy in the face of the dependence imposed by the regulations of a nursing home - refusing care and visitors she did not want, smoking in a public place, and insisting on her daily glass of port..” Ritchie, 1997
(central amyloid core)
(paired helical filaments)
Admission to hospital
N = 130
Meets entry criteria
SYDNEY STROKE STUDY
N=210 (176 + 34)
3 year FU
5 year FU
Our study supports the contention that stroke leads to subtle changes in cognitive functioning in many patients. Immediately after a stroke, patients are usually concerned about its impact on physical functioning, and it is only later that mental functioning comes into focus.
Cognitive impairment is common in stroke patients. More than 50% had some level of cognitive impairment, which was severe in about 25%. Those with larger strokes and who started with a lower baseline function were more likely to have cognitive problems
Sachdev PS, Brodaty H, Valenzuela MJ, Lorentz L, Looi JCL, Wen W, Zagami A. The neuropsychological profile of vascular cognitive impairment in stroke and TIA patients. Neurology 2004;62:912-919.
Sachdev P. Homocysteine, cerebrovascular disease and brain atrophy. [Proceedings of the First Congress of the International Society for Vascular Behavioural and Cognitive Disorders (VAS-COG 2003)] Journal of Neurological Sciences 2004; 226:25-29.
White matter hyperintensities on MRI scans are common in healthy individuals and may represent regions of reduced blood supply. They tend to increase by about 10% per year, and may cause impairment in cognitive and motor function.
Sachdev P, Wen W, Chen X, Brodaty H.Progression of white matter hyperintensities in elderly individuals over 3 years. Neurology 2007; 68:214-222.
Proton spectroscopy is a useful technique to monitor changes related to ageing, and can be used to predict who will develop cognitive decline following stroke. It complements other forms of brain imaging and may have clinical application for this purpose.
Ross AJ, Sachdev PS, Wen W, Brodaty H. Longitudinal Changes During Aging Using Proton Magnetic Resonance Spectroscopy, Journal of Gerontology: MEDICAL SCIENCES, 2006;61A(3)291-298
Ross AJ, Sachdev PS, Wen W, Brodaty H. Prediction of cognitive decline after stroke using proton magnetic resonance spectroscopy, Journal of Neurological Sciences, 2006; 251:62-69
Sachdev PS, Chen X, Joscelyne A, Wen W, Brodaty H. The amygdala in stroke/TIA patients and its relationship to cognitive impairment and psychopathology: The Sydney Stroke Study. American Journal of Geriatric Psychiatry 2007; 15:487-496.
The hippocampus and amygdala are affected early in Alzheimer’s disease, but the pathology of stroke or vascular dementia does not necessarily affect it specifically. In these papers, we show that patients with stroke have smaller hippocampi and amygdalae, which relate to their cognitive status. It is uncertain whether this is due to associated Alzheimer pathology, or due to abnormalities of blood supply. The study suggests that a small hippocampus may not help distinguish Alzheimer’s disease from vascular dementia.
In the first year after the stroke, over a third of patients had significant levels of apathy. This needs to be distinguished carefully from depression as its treatment is quite different.
Brodaty H,SachdevP, Withall A, Koschera A, Valenzuela M, Lorentz L. Frequency and clinical, neuropsychological and neuroimaging correlates of apathy following stroke-The Sydney Stroke Study, Psychological Medicine, 2005;35:1707-1716.
Valenzuela M, Sachdev P. Assessment of complex mental activity across the lifespan: development of the Lifetime of Experiences Questionnaire (LEQ). Psychological Medicine 2007; 37:1015-1025.
Brodaty H, Altendorf A, Withall A, Sachdev PS. Doing well after stroke – The Sydney Stroke Study (in submission).
Fifteen months after their stroke, about a third of patients were doing well in their cognitively and functionally (ie abilities in thinking and managing day-to-day tasks), a third were doing poorly on both and a third had mixed outcome. As expected younger patients were doing better as were those who had less brain atrophy (ie shrinkage) and did not have atrial fibrillation (a specific abnormal rhythm of the heart).
Brodaty H, Withall A, Altendorf A, Sachdev P. Rates of depression at 3 and 15 months Poststroke and their relationship with cognitive decline: the Sydney Stroke Study. American Journal of Geriatric Psychiatry 2007; 15:477-486.
P Sachdev, H Brodaty, J Looi, B McIvor, J Bakas
D Gillies, A Zagami, M Hersch, D Pryor, R Johnston, J Enis
W Wen, A Ross
M Valenzuela, L Lorentz, J Kinch, M Jones, A Walker, J Sims, A Koschera, A Withall
D Monk, L Howard, A Woods
X L Wang, S Easteal
E Milne, P Sawdy, W SchinkeSYDNEY STROKE STUDY TEAM
Financial support of the National Health & Medical Research Council, Univ New South Wales, Rebecca Cooper Foundation, Fairfax Foundation and Old Age Psychiatry Trust Fund