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Keys to Success in Securing NIDA/NIH Funding Shakeh Kaftarian.Ph.D. Division of Epidemiology, Services and Prevention Research November 10, 2005 Vanderbilt University Steps to NIH Grant-Writing Have an idea Match your idea with an NIH Institute Match your idea to a current initiative

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Keys to success in securing nida nih funding l.jpg

Keys to Success in Securing NIDA/NIH Funding

Shakeh Kaftarian.Ph.D.

Division of Epidemiology, Services and Prevention Research

November 10, 2005

Vanderbilt University


Steps to nih grant writing l.jpg
Steps to NIH Grant-Writing

  • Have an idea

  • Match your idea with an NIH Institute

  • Match your idea to a current initiative

  • Find a Project Officer to help you

  • Complete your application

  • Wait (for scientific and programmatic reviews)

    Wait some more Start revising

    (for administrative processing of the award)

If project is strong as-is

If project needs revisions


Where can i get one of these ideas l.jpg
Where can I get one of these “ideas”?

  • GET CURRENT!

    • Review the literature to see what’s been done before

      http://nihlibrary.nih.gov/Elecres/databases.htm

    • Find out if other researchers are interested in similar ideas

    • Check CRISP to see if there is any Federally-funded work being done currently in this area

      http://crisp.cit.nih.gov/crisp/crisp_query.generate_screen



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Match your idea with an Institute

  • Many NIH Institutes may have relevance to your area of interest:

    • NIDA (Drug Abuse)

    • NIAAA (Alcohol Abuse & Alcoholism)

    • NIMH (Mental Health)

    • NICHD (Child Health & Human Development)

    • See: http://www.nih.gov/icd/ for a list

      of NIH Institutes and their missions


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Find yourself a Project Officer(“Cruise Director”)

  • Project Officer (or Program Official or PO) is a scientist with expertise in particular areas of research

  • The PO can help you navigate the grants system (research priorities, current initiatives, application process)

  • The PO can also help identify potential consultants and collaborators, instruments, etc.


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How do I find one of these Project Officers?

  • Search the Institute’s website

    NIDA: http://www.drugabuse.gov/about/organization/Organization.html

  • Call the Institute’s main number

  • Call someone you know


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Match your idea to a current initiative

  • NIH guide: http://grants1.nih.gov/grants/guide/index.html

  • You can join a free listserve that will automatically email a list of all NIH initiatives that are announced each week: http://grants1.nih.gov/grants/guide/listserv.htm

  • NIDA’s website: http://www.drugabuse.gov/funding/


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Types of Initiatives

  • Program Announcement (PA)

  • Request for Applications (RFA)


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Program Announcement (PA)

Standing calls for applications

in general areas

No set-aside funds

Rolling deadlines

(Competes with all other grants in the Division)


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Requests for Application (RFA)

One-time calls for

applications in targeted areas

Funds set-aside for

meritorious applications

Single deadline

(Competes only with other applications in the same RFA)


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Mechanisms:

  • Fellowship Programs (F Series)

  • Research Career Awards (K Series)

  • Research Projects and Research Program Projects (R….., P01)

  • Centers (P30, P50, P60)

  • Training Programs (T Series)

  • Cooperative Agreements (U Series)


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Fellowship programs:

  • F31 Postdoctoral Fellowship (Minority or disabled)

    • Up to 5 years

  • F32 Postdoctoral Individual Award

    • 3 years total support

  • F33 Senior Fellow

    • 2 years support


  • Research career awards l.jpg
    Research Career Awards:

    • K01 Mentored Research Scientist

    • K02 Independent Scientist Award

    • K07 Academic Career Award

    • K08 Mentored Clinical Scientist

    • K12 Mentored Clinical Scientist

    • K23 Mentored Patient-Oriented Research

    • K24 Mid-Career Investigator

    • K25 Mentored quantitative Research


    Research projects and research program projects l.jpg

    NOTE: Amounts and times may be exceeded with prior NIDA approval – contact program official minimum 6 weeks before deadline with full budget and justification.

    Research Projects and Research Program Projects:

    • R01 Research Project (Traditional – $500K/year/5 yrs)

    • R03 Small Grant ($50K/year/2 yrs)

    • R03 B/START Small grant ($50K / pilot study)

    • R13 Conference Grants ($25K / Conferences)

    • R15 Academic Enhancement Research ($150K start-up for new faculty)

    • R21 Exploratory/Developmental Grant (2 yrs/ collect data leading to R01; $275K)

    • R37 Merit Award (Nominated by PO/ exceptional grant and PI – extends original R01 to twice duration)

    • U01 Research Project (Cooperative Agreement)


    Research projects and research program projects16 l.jpg
    Research Projects and Research Program Projects: approval – contact program official minimum 6 weeks before deadline with full budget and justification.

    • R41 (STTR) Phase 1

    • R42 (STTR) Phase 2

    • R43 (SBIR) Phase 1

    • R44 (SBIR) Phase 2


    Centers l.jpg
    Centers: approval – contact program official minimum 6 weeks before deadline with full budget and justification.

    • P20 Exploratory Centers

    • P30 Core Center Grants

    • P50 Specialized Centers

    • P60 Comprehensive Centers


    Roadmap themes l.jpg
    Roadmap Themes approval – contact program official minimum 6 weeks before deadline with full budget and justification.

    • New pathways to discovery

    • Research teams of the future

    • Re-engineering the clinical research enterprise


    Application forms l.jpg
    Application Forms approval – contact program official minimum 6 weeks before deadline with full budget and justification.

    • Applications have use PHS 398 forms (but read the announcement carefully for exceptions)

    • New forms will be used

    • Electronic forms are on the website in Word or PDF format:

      http://grants1.nih.gov/grants/funding/phs398/phs398.html


    Scientific decisions l.jpg
    Scientific Decisions approval – contact program official minimum 6 weeks before deadline with full budget and justification.

    • Study design

    • Population

    • Recruitment strategies

    • Measures used

    • Data collected

    • Analyses needed

    • Research team (PIs, consultants, clinicians)

    • Budget

    • Human Subjects Protections/IRB approvals

    • HIPAA compliance


    Scientific review criteria listed in the grant announcement l.jpg
    Scientific Review Criteria approval – contact program official minimum 6 weeks before deadline with full budget and justification.(listed in the grant announcement)

    • Significance

      • scientific contributions, public health impact

    • Approach

      • theoretical justification, methods, data analytic plan

    • Innovation

      • creativity, charting new waters

    • Investigator

      • experience, publication record, strength of team

    • Environment

      • research-supportiveness of institution of agency

    • Gender/Minority/Children Inclusion

    • Human Subjects Protection


    Priority scores l.jpg
    Priority Scores approval – contact program official minimum 6 weeks before deadline with full budget and justification.

    • Scientific merit judgments are quantified

    • In theory, Priority Scores range from 100 – 500, where 100 = best possible score

    • In practice, Priority Scores rarely exceed 300 because of “triaging” or “unscoring”

    • In general, although there is wide variability, a Priority Score of 150 or lower has a good likelihood of funding


    Triaging or unscoring l.jpg
    Triaging or Unscoring approval – contact program official minimum 6 weeks before deadline with full budget and justification.

    • Review committees are encouraged to identify the bottom half of applications as “unscored”

    • “Unscored” does not mean that the project had no scientific merit; only that it had little chance of funding during that round of review


    Percentile scores l.jpg
    Percentile Scores approval – contact program official minimum 6 weeks before deadline with full budget and justification.

    • Because funding decisions are made based on Priority Scores assigned by different review committees, percentile scores are usually calculated as a way of trying to standardize the Priority Scores

    • Percentile Scores are not calculated for grants reviewed in ad hoc RFA committees, or for training grants reviewed in the training (i.e., “K”) committee

    • In general, although there is great variability, a Percentile Score of 15% or lower has a good likelihood of funding


    Summary statements pink sheets l.jpg
    Summary Statements approval – contact program official minimum 6 weeks before deadline with full budget and justification.(“Pink Sheets”)

    • Priority Score

    • Percentile Score

    • Significance

    • Approach

    • Innovation

    • Investigator

    • Environment

    • Gender/Minority/Children

    • Human Subjects

    • Budget


    The process of scientific peer review l.jpg
    The Process of approval – contact program official minimum 6 weeks before deadline with full budget and justification.Scientific Peer Review


    Review process for a research grant l.jpg
    Review Process for a Research Grant approval – contact program official minimum 6 weeks before deadline with full budget and justification.

    National Institutes of Health

    Center for Scientific Review

    Submits Application

    Assign to IC & IRG/Study Section

    University or Agency Initiates Research Idea

    Study Section

    Review for Scientific Merit

    Institute

    Evaluate for Relevance

    Allocates Funds

    Advisory Councils and Boards

    Conducts Research

    Recommend Action

    Institute Director

    Takes Final Action


    Applications submitted to nih l.jpg
    Applications Submitted to NIH approval – contact program official minimum 6 weeks before deadline with full budget and justification.

    • Approximately 40,000 grant applications are submitted to NIH each year, of which 15-20% are funded

    • Competing grant applications are received for three review cycles per year


    Typical timeline for a new individual research project grant application r01 l.jpg
    Typical Timeline for a New Individual Research Project Grant Application (R01)

    • There are three overlapping cycles per year:

    • Submit in February(June,October)

    • - Review in June (October,February)

    • -Council in September (January,May)

    • -Earliest award in December (April,July)

    Cycle 1 ----

    Cycle 2 ----

    Cycle 3 ----


    Slide31 l.jpg

    Your application is here. Application (R01)


    Slide32 l.jpg

    RFA-DA-06-001 Application (R01)Enhancing Practice Improvement in Community-Based Care for Prevention & Treatment of Drug Abuse or Co-occurring Disorders


    Rfa philosophy l.jpg
    RFA Philosophy Application (R01)

    • Research-to-services AND Services-to-Research

    • Research and service improvement:

      • Adoption, implementation, and sustained use of science-based approaches

      • Understanding factors that hinder adoption, implementation, and sustained use of science-based approaches

      • Testing effectiveness of existing promising but unproven policies and practices

      • Foundation for future research to facilitate continuous practice improvement



    Eligibility requirement provider organization l.jpg
    Eligibility Requirement – Provider Organization (PI)

    A. Community-based Provider Organization

    (1) An organization, an agency, or an association of organizations/agencies (National, State, or Regional) that deliver(s) services to prevent or treat

    (2) Must demonstrate sufficient patient load, N of sites, site size and diversity to study system-wide assessment of existing or newly adopted therapeutic and/or business policies and

    practices.


    Eligibility requirement provider organization36 l.jpg
    Eligibility Requirement – Provider Organization (PI)

    (3) Applications are encouraged from a community-based organization with one or more of the following characteristics:

    - For-profit organizations

    - Non-profit organizations

    - Domestic Institutions

    - Faith-based or community-based organizations

    - Units of Local/State Tribal government


    What does sufficient patient load number of sites site size diversity mean l.jpg
    What does (PI) sufficient patient load, number of sites, site size, & diversity mean?

    • Do you have enough statistical power to answer your research question?

    • Will your results generalize to your whole organization?

    • Will your results generalize to other provider organizations?


    When thinking about an nih research mechanism l.jpg
    When Thinking about an NIH Research Mechanism (PI)

    CONSIDER!!!

    PI experience <-> Project complexity <-> Project budget


    Study design l.jpg
    Study Design (PI)

    Study design should:

    • Match your research question(s)

    • Be as rigorous as possible

    • Be feasible – Don’t plan to do too much!

      Study design can be:

    • Qualitative, quantitative, or a combination

    • Experimental, quasi-experimental



    Readiness and capacity for practice improvement l.jpg
    Readiness and Capacity for Practice Improvement (PI)

    Purpose: Examine implementation of science-based

    practice X and its effects on treatment retention and

    abstinence.

    • Did we implement practice X?

    • Did the practice have the intended effect?

    • How if at all did the intended effect

      contribute to patient outcomes?


    Readiness and capacity for practice improvement42 l.jpg
    Readiness and Capacity for Practice Improvement (PI)

    • Purpose: Examine the implementation of evidence-based practice.

    • Did you implement the service intervention proposed?

    • Did the service intervention have the intended effect?

    • How if at all did the intended effect contribute to patient outcomes?


    Systems level factors that facilitate impede continuous practice improvement l.jpg
    Systems-level Factors that Facilitate/Impede Continuous Practice Improvement

    Purpose: Refine data management system to

    improve performance monitoring.

    • How can we best monitor our performance, and what systemic data do we need to do it?

    • What are our current data collection demands? What more do we need?

    • How feasible are new data collection requirements, and how useful are the new performance measures?


    Systems level factors that facilitate impede continuous practice improvement44 l.jpg
    Systems-level Factors that Facilitate/Impede Continuous Practice Improvement

    Purpose: Identify person centered, program specific and other contextual

    factors that enhance or impede engagement and retention in evidence

    based practice.

    • What are the individual and group differences (religious and spiritual beliefs, traditions, and value systems) to engagement and retention of care?

    • How can culturally appropriate interventions improve accessibility, usability, and sustainability of services in diverse populations?

    • What are the contextual factors (family beliefs) that impact accessibility and sustainability of care?


    Costs and cost effectiveness of practice improvement l.jpg
    Costs and Cost-Effectiveness of Practice Improvement Practice Improvement

    Purpose: Determine the best use of staff training

    budget.

    • What are our current staff training needs?

    • What are two training options for meeting those needs?

    • Which of the two training options will yield the greatest benefit for the dollars spent?


    Don t go it alone l.jpg
    Don’t Go It Alone! Practice Improvement

    • Science

    • Project Management & Staffing

    • Business Component

    • Pulling the Proposal Together


    Questions l.jpg
    Questions Practice Improvement


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