1 / 45

Citoquinas

Citoquinas. Mol

JasminFlorian
Download Presentation

Citoquinas

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

    5. Citoquinas Moléculas co-estimuladoras solubles: citoquinas-quimioquinas Son factores solubles (polipéptidos o glucoproteínas) no antígeno-específicos producidos mayoritariamente por leucocitos, y que intervienen en la regulación de las células del sistema inmune así como en los procesos inflamatorios.

    6. Características Secreción transitoria Actuación por receptores específicos Producidos por diversos tipos celulares Solapamiento Cascada de producción de citoquinas Sinergismo / antagonismo Pleiotropismo: una citoquina tiene múltiples dianas y acciones Cada tipo celular presenta receptores para multiples citoquinas Transmodulación a través de receptor

    23. Receptores para quimioquinas Los efectos biológicos de las quimiocinas están mediados por receptores, en este caso proteínas transmembrana de la superfamilia TM7 acopladas a proteínas G.

    39. IkBa is present in resting T cells but is absent in activated T cells IkBa inhibits NFkB and TNF RNA expression. TNFa, IL-1, IL-6 STNFR, IL-10, IL-1Ra IkBa is overexpressed in sinovial cells of RA patients Rheumathoid sinovial cell cocultures: inhibits production of TNFa, IL-1, IL-6 and IL-8 but do not inhibit IL-10 and IL-Ra. Balance of TNFa production

More Related