Antibiotic Resistance in O.M. Joseph Lopreiato MD,MPH Associate Professor of Pediatrics Uniformed Services University of the Health Sciences Bethesda, MD Nov 1999 Antibiotic Resistance in O.M.
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Joseph Lopreiato MD,MPH
Associate Professor of Pediatrics
Uniformed Services University
of the Health Sciences
“Doctors are men who prescribe medicines of which they know little; to cure diseases of which they know less; in human beings of whom they know nothing” - Voltaire
What’s causing resistant bacteria??
Resistance seems to be correlated with :
J Pediatr 128:757. 1996
Antibiotic use is on the rise. In 1996, percentage of times that antibiotics were prescribed for children:
JAMA 279:875. 1998
Mechanisms of resistance:
Bacteria in otitis media:
Pediatr Infect Dis J. 18:1-9. 1999
Why isn’t there a magic bullet?
100 patients with OM33 viral
33 spontaneous cure33 persist
20 eventual cure13 remain Sx
What to do - Lope’s rules of the Road: