Controlled synthesis of nanoparticles for inhalation exposure studies
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CONTROLLED SYNTHESIS OF NANOPARTICLES FOR INHALATION EXPOSURE STUDIES M. MIETTINEN 1 , V. SUONMAA 1 , U. TAPPER 2 , U. BACKMAN 2 , J. JOUTSENSAARI 1 , A. AUVINEN 2 and J.K. JOKINIEMI 1,2

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Controlled synthesis of nanoparticles for inhalation exposure studies l.jpg

CONTROLLED SYNTHESIS OF NANOPARTICLES FOR INHALATION EXPOSURE STUDIES

M. MIETTINEN1, V. SUONMAA1, U. TAPPER2, U. BACKMAN2, J. JOUTSENSAARI1, A. AUVINEN2 and J.K. JOKINIEMI1,2

1Fine Particle and Aerosol Technology Laboratory, Department of Environmental Science, University of Kuopio, P.O.Box 1627, FI-70211 Kuopio, Finland

2Fine Particles, Technical Research Centre of Finland, P.O. Box 1000, 02044 VTT, Espoo, Finland

NOSA Aerosol Symposium Helsingør, Denmark, 8.-9.11.2007

Mirella Miettinen

M.Sc., Research Scientist


Background l.jpg
BACKGROUND

  • Nanohealth research consortium

    • University of Kuopio

    • University of Helsinki

    • Finnish Institute of Occupational Health

  • Objectives

    • controlled production of engineered nanoparticles

    • exposure assessment in occupational environments

    • adverse effects of nanoparticles

      • airway irritation and changes in the respiratory patterns

      • inflammatory responses of the lungs and pulmonary cells

      • genotoxicity

Mirella Miettinen

M.Sc., Research Scientist


Experimental set up l.jpg
EXPERIMENTAL SET-UP

  • flow reactor

  • Ti(C3H7O)4 liquid precursor in bubbler

  • N2 carrier gas

  • Ti(C3H7O)4 → TiO2 + 4C3H6 + 2H2O

  • dilution with dry and humified air

  • size distributions: SMPS (3071A DMA+3022A CPC)

  • gaseous byproducts: FTIR (GASMETTM)

  • mass concentration: filter samples (Teflon,Gelman)

  • TEM, XRD, BET

heat

Mirella Miettinen

M.Sc., Research Scientist


Slide4 l.jpg

PC = pressure controller

CO = critical orifice

EXH = exhaust

= heated line

CO

PC

PC

CO

CO

PC

Qd2

p

fabric filter

EXH

EXH

Qd1

MFC

Tb = bubbler temperature

T2 = reactor temperature

Qb = N2 flow through bubbler

Qr = residence time N2 flow

Qd = prim. dilution air flow

Qd2 = secondary dilution air flow

FTIR

HEPA

T

T2

room air

TEM

EXPOSURE

CHAMBER

SMPS

12 slpm

Qb

Qr

Tb

Mirella Miettinen

M.Sc., Research Scientist

N2


Results reactor t and residence time l.jpg
RESULTS: REACTOR T AND RESIDENCE TIME

Mirella Miettinen

M.Sc., Research Scientist


Slide6 l.jpg

T2 = 500 °C, Qr = 1.8 slpm

T2 = 800 °C, Qr = 0.5 slpm

Mirella Miettinen

M.Sc., Research Scientist


Slide7 l.jpg

3

T2 = 500 °C, Qr = 1.8 slpm

,)

H2O

RH(%)

40.1

C3H6

ppm

38.4

ppm

4.5

CO

ppm

2.1

NOx

18.3

vol %

O2

0

10

20

30

40

50

60

70

80

90

100

3

T2 = 800 °C, Qr = 0.5 slpm

,

H2O

46.7

RH(%)

C3H6

ppm

14.7

ppm

23.2

CO

4.1

ppm

CH4

19.4

vol %

O2

0

10

20

30

40

50

60

70

80

90

100

Mirella Miettinen

M.Sc., Research Scientist


Results dilution ratio l.jpg
RESULTS: DILUTION RATIO

Mirella Miettinen

M.Sc., Research Scientist


Conclusions and future l.jpg
CONCLUSIONS AND FUTURE

  • Highly controlled nanoparticle generator

  • Adjustable and repeatable

  • Inhalation exposure experiments have just started

  • In future new materials: copper, cobalt

Mirella Miettinen

M.Sc., Research Scientist


Acknowledgements l.jpg
ACKNOWLEDGEMENTS

This work was funded by the Academy of Finland (decision number 118114) in the FinNano research program

Mirella Miettinen

M.Sc., Research Scientist


Thank you and bon appetit l.jpg
THANK YOUAND BON APPETIT!

Mirella Miettinen

M.Sc., Research Scientist


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