1 / 27

Diuretics

Diuretics. By S.Bohlooli, PhD. Renal Tubular Transport Mechanism. Proximal Tubule Loop of Henle Distal Convoluted Tubule Collecting Tubule. Renal Tubular Transport. Basic Pharmacology of Diuretic agents. Carbonic anhydrase inhibitors Loop diuretics Thiazides

Gabriel
Download Presentation

Diuretics

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Diuretics By S.Bohlooli, PhD

  2. Renal Tubular Transport Mechanism • Proximal Tubule • Loop of Henle • Distal Convoluted Tubule • Collecting Tubule

  3. Renal Tubular Transport

  4. Basic Pharmacology of Diuretic agents • Carbonic anhydrase inhibitors • Loop diuretics • Thiazides • Potassium-sparing diuretics

  5. Carbonic anhydrase inhibitors

  6. NaHCO3 reabsorption in proximal tubule and mechanism of diuretic action of carbonic anhydrase inhibitors

  7. Applications • Glaucoma • Urinary alkalinization • Metabolic alkalosis • Acute mountain disease • Epilepsy, hypokalemic periodic paralysis

  8. Toxicity • Hyperchloremic metabolic acidosis • Renal stones • Renal potassium wasting • Hypersensivity reactions • Contraindicated in patients with cirrhosis

  9. Loop diuretics

  10. Loop diuretics

  11. NaCl reabsorption in thick ascending limb and mechanism of diuretic action of Na+-K+-2Cl- symport inhibitors

  12. Applications • Acute pulmonary edema • Acute hypercalcemia • Hyperkalemia • Acute renal failure • Anion overdose

  13. Toxicity • Hypokalemic metabolic acidosis • Ototoxicity • Hyperuricemia • Hypomagnesimia • Allergic reactions • Contraindicated in hepatic cirrhosis, borderline renal failure and heart failure

  14. Thiazides

  15. Thiazides

  16. Thiazides

  17. Applications • Hypertension • Heart failure • Nephrolithiasis • Nephrogenic diabetes

  18. Toxicity • Hypokalemic metabolic alkalosis • Hyperuricemia • Impaired carbohydrate tolerance • Hyperlipidemia • Hyponatremia • Allergic reactions

  19. Potassium-sparing diuretics: channel blockers

  20. Potassium-sparing diuretics

  21. ANTAGONISTS OF MINERALOCORTICOID RECEPTORS

  22. ANTAGONISTS OF MINERALOCORTICOID RECEPTORS

  23. Applications • State of mineralocorticoid excess

  24. Toxicity • Hyperkalemia • Hyperchloremic metabolic acidosis • Gynecomastia • Acute renal failure: triamterene & indomethacin • Kidney stones: triamterene is insoluble

  25. Diuretics: summery

  26. Clinical Pharmacology of Diuretic Agents • Edematous states • Heart Failure • Kidney Diseases • Hepatic cirrhosis • Idiopatic edema • Nonedematous states • Hypertension • Nerphrolithiasis • Hypercalcemia • Diabetes insipidus

  27. Good Luck

More Related