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Traditional practices in South Africa. Vanessa Steenkamp Department of Pharmacology University of Pretoria. 200 000 healers 80% population. Callilepis laureola DC. Ox-eye daisy Impila . Decongestant Induce fertility Ward off “evil spirits”. Atractyloside Carboxyatractyloside

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Traditional practices in

South Africa

Vanessa Steenkamp

Department of Pharmacology

University of Pretoria


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200 000 healers

80% population


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Callilepis laureola DC.

Ox-eye daisy

Impila

  • Decongestant

  • Induce fertility

  • Ward off “evil spirits”


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Atractyloside

Carboxyatractyloside

Inhibits transport of ADP

into mitochondria

No synthesis of ATP

Cell death

Presentation:

Hepatocellular failure

Nephrotoxicity

80% confused/ coma

95% hypoglycaemia

87% metabolic acidosis


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Senecio latifolius DC.

Ragwort, groundsel

  • Induce abortion

  • Skin eruptions

  • Chest pains

  • Palpitations


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Retrorsine

(pyrrolizidine alkaloid)

Damages vascular

endothelium

VOD

Presentation

96% ascites

85% hepatomegaly

92% liver enzymes


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Urginea sanguinea Shinz.

Squill (slangkop)

  • Veneral diseases

  • Blood purifier


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Scillaren A

Digitalis-like effect

AV block

Rhythm disturbance

Presentation

Gastrointestinal symptoms

Nausea

Vomiting


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Aloe ferox Mill.

Cape aloe

T: Laxative

Arthritis

Eczema

Conjuctivitis

Hypertension

Stress

Wounds

C: laxative


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Aloin

Aloeresin

Aloe-emodin anthrone

Laxative action

Wound-healing - glycoproteins


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Agathosma betulina

(Berg.) Pill.

Buchu

T:stomach complaints

kidney

urinary tract

rheumatism

C: urinary tract


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Pulegone

Isomenthone

Diosphenol

Antiseptic

+

diuretic


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Hypoxis hemerocallidea

Fisch. & CA Mey.

African potato

T: Emetics, dizziness

Bladder disorders

Insanity

Prostate problems

C: BPH

Urinary infections


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Rooperol

Anti-cancer

Anti-HIV

Anti-inflammatory

Sitosterols

Inhibition 5α-reductase

Less DHT


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Harpagophytum procumbens

DC.

Devil’s claw

T: Rheumatism, arthritis

C: General health


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Harpagoside

Harpagide

Analgesic

Anti-inflammatory


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Sutherlandia frutescens (L.)R. Br.

Cancer bush

T: Cancer

gastric ailments

oedema

blood purifier

C: general health

tonic


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Canavanine

L-arginine antagonist

Anticancer

Antiviral

Pinitol – anti-diabetic agent

GABA:- inhibitory neurotransmitter – anxiety and stress


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Current research:

  • Toxicity in vervet monkeys: biochemical, haematological,

  • physiological and physical variables : Seier et al. 2002

  • Analgesic, anti-inflammatory, hypoglycemic effects:

  • Ojewole 2004

  • Antioxidant potential: Fernandes et al. 2004

  • Effect on COX-2 expression: Kundu et al. 2005

  • Anti-HIV activities: Harnett et al. 2005


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Sutherlandia has earned the reputation of

being an excellent tonic for bringing about

a general feeling of wellbeing and calmness,

for boosting the immune system and

bolstering energy levels during illness or

convalescence.


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Indigenous systems of medicine

are dynamic and adaptive,

although firmly rooted in the

traditions of the past.

This is evident from the

incorporation of medical herbs

into materica medica.


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