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Traditional practices in South Africa. Vanessa Steenkamp Department of Pharmacology University of Pretoria. 200 000 healers 80% population. Callilepis laureola DC. Ox-eye daisy Impila . Decongestant Induce fertility Ward off “evil spirits”. Atractyloside Carboxyatractyloside

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slide1

Traditional practices in

South Africa

Vanessa Steenkamp

Department of Pharmacology

University of Pretoria

slide2

200 000 healers

80% population

slide5

Callilepis laureola DC.

Ox-eye daisy

Impila

  • Decongestant
  • Induce fertility
  • Ward off “evil spirits”
slide6

Atractyloside

Carboxyatractyloside

Inhibits transport of ADP

into mitochondria

No synthesis of ATP

Cell death

Presentation:

Hepatocellular failure

Nephrotoxicity

80% confused/ coma

95% hypoglycaemia

87% metabolic acidosis

slide7

Senecio latifolius DC.

Ragwort, groundsel

  • Induce abortion
  • Skin eruptions
  • Chest pains
  • Palpitations
slide8

Retrorsine

(pyrrolizidine alkaloid)

Damages vascular

endothelium

VOD

Presentation

96% ascites

85% hepatomegaly

92% liver enzymes

slide9

Urginea sanguinea Shinz.

Squill (slangkop)

  • Veneral diseases
  • Blood purifier
slide10

Scillaren A

Digitalis-like effect

AV block

Rhythm disturbance

Presentation

Gastrointestinal symptoms

Nausea

Vomiting

slide11

Aloe ferox Mill.

Cape aloe

T: Laxative

Arthritis

Eczema

Conjuctivitis

Hypertension

Stress

Wounds

C: laxative

slide12

Aloin

Aloeresin

Aloe-emodin anthrone

Laxative action

Wound-healing - glycoproteins

slide13

Agathosma betulina

(Berg.) Pill.

Buchu

T:stomach complaints

kidney

urinary tract

rheumatism

C: urinary tract

slide14

Pulegone

Isomenthone

Diosphenol

Antiseptic

+

diuretic

slide15

Hypoxis hemerocallidea

Fisch. & CA Mey.

African potato

T: Emetics, dizziness

Bladder disorders

Insanity

Prostate problems

C: BPH

Urinary infections

slide16

Rooperol

Anti-cancer

Anti-HIV

Anti-inflammatory

Sitosterols

Inhibition 5α-reductase

Less DHT

slide17

Harpagophytum procumbens

DC.

Devil’s claw

T: Rheumatism, arthritis

C: General health

slide18

Harpagoside

Harpagide

Analgesic

Anti-inflammatory

slide19

Sutherlandia frutescens (L.)R. Br.

Cancer bush

T: Cancer

gastric ailments

oedema

blood purifier

C: general health

tonic

slide20

Canavanine

L-arginine antagonist

Anticancer

Antiviral

Pinitol – anti-diabetic agent

GABA:- inhibitory neurotransmitter – anxiety and stress

slide21

Current research:

  • Toxicity in vervet monkeys: biochemical, haematological,
  • physiological and physical variables : Seier et al. 2002
  • Analgesic, anti-inflammatory, hypoglycemic effects:
  • Ojewole 2004
  • Antioxidant potential: Fernandes et al. 2004
  • Effect on COX-2 expression: Kundu et al. 2005
  • Anti-HIV activities: Harnett et al. 2005
slide22

Sutherlandia has earned the reputation of

being an excellent tonic for bringing about

a general feeling of wellbeing and calmness,

for boosting the immune system and

bolstering energy levels during illness or

convalescence.

slide23

Indigenous systems of medicine

are dynamic and adaptive,

although firmly rooted in the

traditions of the past.

This is evident from the

incorporation of medical herbs

into materica medica.

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