Lecture 25 respiration 2
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Lecture 25 Respiration #2. Diseases detected by PV curves. Air flow transducer - Pneumotachometer. Nitrogen washout. Air flow transducer. Full body plethysmograph. Measurement of airway resistance. Dubois shutter method

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Lecture 25 Respiration #2

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Lecture 25Respiration #2


Diseases detected by PV curves


Air flow transducer - Pneumotachometer


Nitrogen washout


Air flow transducer


Full body plethysmograph


Measurement of airway resistance

  • Dubois shutter method

  • Measurement of pressure in full body plethysmograph using calibration Pump

  • PV=NRT = gas law


Compliance –static model


Dynamic compliance

C = Volume/Pressure

Volume = integrate flow

Press = difference at flow=0


Pressure volume curves


Pulse Compliance


Detector for respiratory cycle position


Instantaneous compliance


Compliance –instantaneous


Harry Puffer setup


Retrograde catheter(set R=0)


Pulse stimulus


Pressure units

  • Atmospheric pressure ~14.7 pounds/sq inch

  • Daily barometric pressure - 30 cm Hg or 762 mmHg

  • Or 10.3 meters water or 33 ft


Pressure calculations

  • Today’s barometric pressure = 30.03 cm Hg

  • Or 760 mmHg

  • % Oxygen = 20.94%

  • Partial pressure of oxygen ~160 mmHg

  • Pressure of oxygen in hemoglobin = 100

  • Venous oxygen pressure = 40


Hemoglobin dissociation curve

Effect pf Ph (Push to Right)

Effect of sickle cell (push to left)

Carbon monoxide

Temperature (push to right)

Organic Phosphates (push to right)


Gas pressures at body locations


Other pressure effects

  • High altitude

  • Mount Kilimanjaro

  • Mount Everest

  • Blood Oxygen saturation – ear clip

  • Measurement of PO2

  • Carbon dioxide in brain – hyper ventilation

  • Sleep patterns

  • Artificial lungs


Ventilators

  • Design

  • Purpose

  • How it feels

  • High frequency type

  • Neonatal nursery

  • Danger of pure oxygen


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