Research Highlights from the National Institute of Diabetes and Digestive and Kidney Diseases. Griffin P. Rodgers, M.D., M.A.C.P. Acting Director. National Institute of Diabetes and Digestive and Kidney Diseases. Diabetes, Endocrinology, and Metabolic Diseases;
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Griffin P. Rodgers, M.D., M.A.C.P.
The NIDDK conducts and supports basic and applied research and provides leadership for a national program in:
“Bench to Bedside and Beyond”
Division of Kidney,
Division of Diabetes,
For Children and Adolescents
obstructive sleep apnea
Coronary heart disease
Nonalcoholic fatty liver disease
polycystic ovarian syndrome
Gall bladder disease
breast, uterus, cervix, prostate, kidney
colon, esophagus, pancreas, liver
1991 Scientific DivisionsObesity Trends Among U.S. Adults
No Data <10% 10-14% 15-19% 20-24% ≥25%
6-11 years old
12-19 years old
(e.g., body mass index)
1994 Scientific Divisions
2004Estimates of Diagnosed Diabetes Among Adults in the U.S.
No Data <4% 4-4.9% 5-5.9% ≥6%
Diagnosed Diabetes in the U.S. Scientific Divisions
Diagnosed (1960-2004) and
Projected Diagnosed (2005-2050) Cases
15 Scientific Divisions
Cases per 100 person-years
LifestyleResults from the Diabetes Prevention Program Substantial Reduction in Diabetesin All Race-Ethnic Groups
→ coma, death
But, progress has not yet been realized across all U.S. populations
Per million population
Conventional Scientific Divisions
p = 0.001
Eye Disease: Intensive Diabetes Treatment Reduces Risk
Cumulative Incidence of > 3-Step Change
Conventional Scientific Divisions
Heart Disease: Intensive Diabetes Treatment Reduces Risk
Cumulative Incidence of Nonfatal
Myocardial Infarction, Stroke, or
Death from Cardiovascular Disease
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
Years Since Entry into DCCT/EDIC Study
Developed by the NIH Obesity Research Task Force with
critical input from external scientists and the public
Although listed separately, the first two themes are interdependent. We seek to create an interdisciplinary approach in which lifestyle interventions are informed by an understanding of the basic biological and genetic factors and vice versa.
Highlights of Program Efforts, Research Advances and Opportunities related to:
Weight-control Scientific DivisionsInformation Network
The Weight-control Information Network (WIN) is an information service of the NIDDK. WIN was established in 1994 to provide the general public, health professionals, the media, and Congress with up-to-date, science-based information on obesity, weight control, physical activity, and related nutritional issues.
WIN produces, collects, and disseminates materials on obesity, weight control, and nutrition.
The National Diabetes Education Program (NDEP) is a federally funded program sponsored by the National Institutes of Health and the Centers for Disease Control and Prevention and includes over 200 partners at the federal, state, and local levels, working together to reduce the morbidity and mortality associated with diabetes.
N Scientific DivisionsKDEPNational Kidney DiseaseEducation Program
The National Kidney Disease Education Program (NKDEP) is an initiative of the National Institutes of Health, designed to reduce the morbidity and mortality caused by kidney disease and its complications.
Aerial View of NIH campus in Bethesda, MD Scientific Divisions