1 / 24

nuclear receptor

nuclear receptor as one of drug target

BesseHardianti
Download Presentation

nuclear receptor

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Reseptor inti(nuclear receptor) Nuclear Receptor

  2. Pathway maps Transcription_Androgen Receptor nuclear signaling

  3. Reseptor inti(nuclear receptor) • Berada di dalamsel (sitoplasma) atau di nukleus aktivitasnyaberada di dalamintiaktivitasutama : regulasitranskripsigen • Liganuntukreseptor ini umumnyaberbobotmolekulkecil(< 1000 dalton), bersifatlipofilik, mudahmasukkedalamseluntukmencapaireseptor-nya • Contohligan : hormonglukokortikoid, vitamin D, asamretinoat, danhormontiroid, dll.

  4. SHR SHR RXR ? R Classification - subfamilies • Subfamilies • Type I: Steroid receptors • undergonuclear translocation upon ligand activation • bind as homodimers to invertedrepeat DNA half sites, • Type II: RXR heterodimers • retained in thenucleusregardlessofthepresenceof ligand • usually bind as heterodimers with RXR to directrepeats. • Type III: orphanNRs • dimericorphanreceptors • Monomericorphanreceptors • Half receptors

  5. Altern.class. • Evolutionaryanalysisofthereceptors has led to a subdivision in six different subfamilies

  6. Lokasi Reseptor

  7. Reseptor steroid Steroid ? • Senyawa lipid yang memiliki 3 cincinsikloheksandan 1 cincinsiklopentan contoh ? • kolesterol, hormon estrogen, testosteron, kortikoid, dll Kortikosteroid ? • Steroid yang disintesisdandilepaskanoleh cortex adrenal : ada 2 : glukokortikoiddanmineralokortikoid • Padamanusia: • glukokortikoidutamaadalahkortisol/ hidrokortison (padatikus: kortikosteron), danmineralokortikoidutamaadalahaldosteron

  8. MekanismekerjaGlukodan mineral (Kortokoid)

  9. Perbandingan Aktivitas Kortikosteroid

  10. Bagaimanasteroidbekerja ? • Steroid (glukokortikoid, mineralokortikoid) bekerjadengan cara berikatandenganreseptornyasuatureseptorintraselulermeregulasitranskripsigenmRNA proteintertentumempengaruhifungsiseltertentu • Reseptorsteroidjikasedangtidakberikatandgnliganbisaterdapat di dalamnukleusatauberada di luarnukleusdenganberikatandengansuatuprotein chaperon (pengantar), yaituheat shock proteins (hsps)

  11. Issues and Resolutions • Description of the issue • How was it resolved? • What and how did it impact the project? • Time • Cost • Other

  12. Timeline

  13. Looking Ahead

  14. Appendix • Budget • Design documents • Marketing plan • Supplemental documents • Contact information

  15. PPAR receptor

  16. Bioactive lipids and theirnuclearreceptors

  17. Thank you for attention

More Related