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T cell immunology Kim Min Sung Abstract Introduction T cell receptor, TCR T cell accessory molecules Introduction The kind of a T cell. The facility of a T cell. a CD8 T cell with a CD4 t cell. MHC resrtiction MHC : major histocompatibility complex

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T cell immunology l.jpg

T cell immunology

Kim Min Sung


Abstract l.jpg
Abstract

  • Introduction

  • T cell receptor, TCR

  • T cell accessory molecules






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MHC resrtiction

  • MHC : major histocompatibility complex

  • T cell can recognize necessarily the antigen through MHC molecule and recognizes the part of the antigen.



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T cell receptor

  • TCR : Antigen awareness acceptor in T cell surface.

    Consist of αβ T cell receptor that is consisted of α and

    β chain and part consists of γδ T cell receptor that is

    consisted of γ and δ chain.

  • αβ T cell receptor : Have been revealed in most peripheral T

    cell and is limited by MHC.

  • γδ T cell receptor : Only, it is special kind of T cell that it is

    known as that have been revealed in tip of a twig blood

    T cell of decimal and is not limited by MHC.


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αβ T cell receptor

  • α, β chain two proteins are achieved gathering, these two protein chains each other cavalent bond being done in cell membrane exist .

  • α chain : Cell membrane protein that have about 40 ~ 50 KDa's molecular weight by acidic glycoprotein .

  • β chain : Cell membrane protein that have about 40 ~ 45 KDa's molecular weight by neuter gender or basic glycoprotein .

  • α, β chain is accomplishing CD3 protein and complex in cell membrane, call that is CD3-TCR complex usually.


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γδ T cell receptor

  • γδ TCR appear, and is revealed in particular peripheral T cell of decimal which do not reveal αβ TCR also in ripening immature thymocyte.

  • Revelation in T cell of particular area such as intraepithelial lymphocyter (T cell in head's mucosa) or dendritic epidermal cells (T cell in cuticle formation)

  • Confirmation that recognize PPD (purified protein derivatives) of tuberculosis germs or heat shock protein

  • Is thought if is resemblant with NK cell that destroy cancerous cells, or do not act on cell that remove cell that is damaged by inflammation effect.


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Solid structure of TCR and MHC

  • Upper direction is TCR, and down is MHC.

  • Part that color paints in picture is part that TCR and MHC do interaction directly.




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T cell accessory molecules

  • Is low comparatively than union protein plain that TCR's antigen affinity is different including antibody.

  • Coherence between TCR and MHC-peptide complex is not enough to stimulate T cell in antigen awareness through TCR.

  • T cell's antigen awareness need union between other molecules that make their coherence durably to TCR except.

  • CD2, CD4, CD8, LFA-1 protein etc. are representative accessory molecules



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CD4, CD8

  • CD4 : · Glycoprotein in cell membrane about 55 kDa .

    · In Leu3 or T4, mouse in a person L3T4 . Person's

    CD4 is acceptor of HIV virus.

    · CD4 is union to class II MHC's non-polymorphic

    region.

  • CD8 : · Glycoprotein that is combined in cell membrane that

    is consisted of α and β relationship two proteins .

    · In Leu2 or T8, mouse in a person Lyt-2/Lyt-3 .

    · CD8 is union to class I MHC's non-polymorphic

    region.


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Other accessory molecules

  • CD2 : Is called that is T11, LFA-2, Leu5, SRBC receptor by

    membrane glycoprotein.

    Ligand is LFA-3 or CD58.

    Function as signal transducing molecules .

  • LFA-1 (lymphocyte function-associated antigen-1) :

    Cell union protein (adhesion molecule) belonging to

    integrin family .

    Ligand is ICAM-1 and ICAM-2.

  • Other accessory molecules :

    CD28, CD44, CD45, CD5, Thy-1, Ly-6


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