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Incidence of stroke decreased after the STOP trial. Fullerton HJ, et al. Blood. 2004;104:336-9.. Since the publication of the STOP trial in 1998, the annual rates of stroke for children in California have declined. Agenda. The incidence and risk factors for stroke Why do children with SCD have strokes?Prevention of strokeSTOP I and STOP II trialsimpact of hydroxyureathe role of HSCT.

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